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STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE

X-ray diffraction
2.1Å resolution
PDB entry 1axi coloured by chain, front view.
PDB entry 1axi coloured by chain, side view.
PDB entry 1axi coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Somatotropin and Growth hormone-binding protein
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Multimeric state: hetero tetramer
Accessible surface area: 32528.05 Å2
Buried surface area: 8743.7 Å2
Dissociation area: 1,663.57 Å2
Dissociation energy (ΔGdiss): 16.6 kcal/mol
Dissociation entropy (TΔSdiss): 14.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-134132

Macromolecules

Somatotropin
Chain: A
Length: 191 amino acids
Theoretical weight: 22.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01241 (Residues: 27-217; Coverage: 100%)
Gene name: GH1
Pfam: Somatotropin hormone family
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Long-chain cytokines
Somatotropin in PDB entry 1axi, assembly 1, front view.
Somatotropin in PDB entry 1axi, assembly 1, side view.
Somatotropin in PDB entry 1axi, assembly 1, top view.
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Growth hormone-binding protein
Chain: B
Length: 236 amino acids
Theoretical weight: 27.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10912 (Residues: 19-254; Coverage: 38%)
Gene name: GHR
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Growth hormone-binding protein in PDB entry 1axi, assembly 1, front view.
Growth hormone-binding protein in PDB entry 1axi, assembly 1, side view.
Growth hormone-binding protein in PDB entry 1axi, assembly 1, top view.
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