Domain

Growth hormone/erythropoietin receptor, ligand binding (IPR015152)

Short name: Growth/epo_recpt_lig-bind

Domain relationships

None.

Description

Members of this entry include the growth hormone and erythropoietin receptors. The latter interacts with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signalling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions [PMID: 9774108].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam