Conserved Site

Long hematopoietin receptor, single chain, conserved site (IPR003528)

Short name: Long_hematopoietin_rcpt_CS


A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [PMID: 1400369] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins.

Several receptor chains for large hematopoietins are structurally related such that their extracellular parts strictly contain the 200 amino-acids hematopoietin domain, duplicated in the thrombopoietin receptor and in avian prolactin receptors. This subgroup of receptor chains contains: Growth hormone receptor (GHR), Prolactin receptor (PRLR), Erythropoietin receptor (EPOR), Thrombopoietin receptor (TPOR).

A schematic representation of the structure of these receptors is shown below:

 | C C       C  C  Extracellular          XXXXXXX       Cytoplasmic       |
   | |       |  |                      Transmembrane
   +-+       +--+

These receptor chains are single components of receptors that homodimerize upon binding of the cognate cytokine, following the structural model described for the growth hormone-receptor complex [PMID: 1549776].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004896 cytokine receptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns