Structure for leupeptin (S01.001, C01.001 inhibitor)

Summary Structure Literature

PDB	Organism	Resolution	Comment
1JRS	Bos taurus	1.80 Å	complex with leupeptin
Catalytic residues are shown in ball-and-stick representation: His60 in purple, Asp104 in pink and Ser197 in orange. The structural calcium ion is shown as a yellow CPK sphere. Bound inhibitor is shown in grey in ball-and-stick representation.

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2F9P	Homo sapiens	2.30 Å	Asp216Gly mutant; complex with leupeptin
Catalytic residues are shown in ball-and-stick representation: His74 in purple, Asp121 in pink and Ser224 in orange. Bound inhibitor is shown in grey in ball-and-stick representation.

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2FO5_A	Hordeum vulgare	2.20 Å	isoform 2 (EP-B2); complex with leupeptin
One monomer of the tetramer is shown. Catalytic residues are shown in ball-and-stick representation: Gln152 in light pink, Cys158 in yellow, His297 in purple and Asn318 in dark pink.

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2PSY	Homo sapiens	2.30 Å	complex with leupeptin and zinc
Catalytic residues are shown in ball-and-stick representation: Asp102 in pink, His57 in purple and Ser195 in orange.

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3BPM_A	Plasmodium falciparum	2.50 Å	complex with leupeptin
Catalytic residues are shown in ball-and-stick representation: Gln287 in dark pink, Cys51 in yellow, His425 in purple and Asn455 in light pink. The bound inhibitor leupeptin is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
actinidin ( Actinidia deliciosa)
theoretical model; complex with leupeptin	0.00 Å	1FOG	1FOG	1FOG	1FOG	1FOG	1FOG
trypsin 1 ( Bos taurus)
complex with leupeptin	1.80 Å	1JRS	1JRS	1JRS	1JRS	1JRS	1JRS	Kurinov & Harrison, 1996
complex with leupeptin	1.80 Å	1JRT	1JRT	1JRT	1JRT	1JRT	1JRT	Kurinov & Harrison, 1996
complex with leupeptin	1.14 Å	2AGI	2AGI	2AGI	2AGI	2AGI	2AGI	Radisky et al., 2006
caricain ( Carica papaya)
theoretical model; Asp158Glu mutant in complex with leupeptin	0.00 Å	1F1I	1F1I	1F1I	1F1I	1F1I	1F1I
papain ( Carica papaya)
complex with leupeptin	2.10 Å	1POP	1POP	1POP	1POP	1POP	1POP	Schroder et al., 1993
tryptase alpha ( Homo sapiens)
Lys192Gln, Asp216Gly double mutant; complex with leupeptin	1.60 Å	2F9N	2F9N	2F9N	2F9N	2F9N	2F9N	Rohr et al., 2006
Asp216Gly mutant; complex with leupeptin	2.30 Å	2F9P	2F9P	2F9P	2F9P	2F9P	2F9P	Rohr et al., 2006
calpain-9 ( Homo sapiens)
complex with leupeptin	2.50 Å	2P0R	2P0R	2P0R	2P0R	2P0R	2P0R
kallikrein-related peptidase 5 ( Homo sapiens)
complex with leupeptin	2.30 Å	2PSX	2PSX	2PSX	2PSX	2PSX	2PSX	Debela et al., 2007
complex with leupeptin and zinc	2.30 Å	2PSY	2PSY	2PSY	2PSY	2PSY	2PSY	Debela et al., 2007
kallikrein-related peptidase 8 ( Homo sapiens)
complex with leupeptin	2.10 Å	5MS4	5MS4	5MS4	5MS4	5MS4	5MS4
calpain-3 ( Homo sapiens)
protease core; complex with leupeptin	3.20 Å	6BKJ	6BKJ	6BKJ	6BKJ	6BKJ	6BKJ
endopeptidase-B (Hordeum-type) ( Hordeum vulgare)
isoform 2 (EP-B2); complex with leupeptin	2.20 Å	2FO5	2FO5	2FO5	2FO5	2FO5	2FO5	Bethune et al., 2006
falcipain-3 ( Plasmodium falciparum)
complex with leupeptin	2.50 Å	3BPM	3BPM	3BPM	3BPM	3BPM	3BPM	Kerr et al., 2009
calpain-1 ( Rattus norvegicus)
protease core; complex with leupeptin	1.80 Å	1TL9	1TL9	1TL9	1TL9	1TL9	1TL9	Moldoveanu et al., 2004