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Literature for leupeptin (S01.001, C01.001 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, I Inhibitor, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2018
  1. Dugue,R., Hassen,G.W., Shulman,A., Goodman,J.H., Michelson,H., Serrano,P., Chauhan,S. and Ling,D.S.F.
    Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur
    Brain Res Bull (2018) 142, 368-373. PubMed  Europe PubMed DOI  I
  2. Hassen,G.W., Kesner,L., Stracher,A., Shulman,A., Rockenstein,E., Mante,M., Adame,A., Overk,C., Rissman,R.A. and Masliah,E.
    Effects of novel calpain inhibitors in transgenic animal model of Parkinson's disease/dementia with Lewy bodies
    Sci Rep (2018) 8, 18083-18083. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2017
  3. Hashimoto,Y.
    Gelatin zymography using leupeptin for the detection of various cathepsin L forms
    Methods Mol Biol (2017) 1594, 243-254. PubMed  Europe PubMed DOI  L  I
  4. Shoji,A., Suenaga,Y., Hosaka,A., Ishida,Y., Yanagida,A. and Sugawara,M.
    Inhibitory assay for degradation of collagen IV by cathepsin B with a surface plasmon resonance sensor
    J Pharm Biomed Anal (2017) 145, 79-83. PubMed  Europe PubMed DOI  I
    5. 2015
  5. Zoratti,G.L., Tanabe,L.M., Varela,F.A., Murray,A.S., Bergum,C., Colombo,E., Lang,J.E., Molinolo,A.A., Leduc,R., Marsault,E., Boerner,J. and List,K.
    Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling
    Nat Commun (2015) 6, 6776-6776. PubMed  Europe PubMed DOI  I
    6. 2014
  6. Hausner,T., Marvaldi,L., Marton,G., Pajer,K., Hopf,R., Schmidhammer,R., Hausott,B., Redl,H., Nogradi,A. and Klimaschewski,L.
    Inhibition of calpains fails to improve regeneration through a peripheral nerve conduit
    Neurosci Lett (2014) 566, 280-285. PubMed  Europe PubMed DOI  I
    7. 2011
  7. Haspel,J., Shaik,R.S., Ifedigbo,E., Nakahira,K., Dolinay,T., Englert,J.A. and Choi,A.M.
    Characterization of macroautophagic flux in vivo using a leupeptin-based assay
    Autophagy (2011) 7, 629-642. PubMed  Europe PubMed DOI  I
    8. 2009
  8. Kerr,I.D., Lee,J.H., Pandey,K.C., Harrison,A., Sajid,M., Rosenthal,P.J. and Brinen,L.S.
    Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity
    J Med Chem (2009) 52, 852-857. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    9. 2007
  9. Maes,K., Testelmans,D., Powers,S., Decramer,M. and Gayan-Ramirez,G.
    Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats
    Am J Respir Crit Care Med (2007) 175, 1134-1138. PubMed  Europe PubMed DOI  I
    10. 2006
  10. Momiyama,J., Hashimoto,T., Matsubara,A., Futai,K., Namba,A. and Shinkawa,H.
    Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity
    Tohoku J Exp Med (2006) 209, 89-97. PubMed  Europe PubMed DOI  I
    11. 2004
  11. [YEAR:5-12-2004]Moldoveanu,T., Campbell,R.L., Cuerrier,D. and Davies,P.L.
    Crystal structures of calpain-E64 and -leupeptin inhibitor complexes reveal mobile loops gating the active site
    J Mol Biol (5-12-2004) 343, 1313-1326. PubMed  Europe PubMed DOI  S  I
    12. 1997
  12. Mains,R.E., Berard,C.A., Denault,J.B., Zhou,A., Johnson,R.C. and Leduc,R.
    PACE4: a subtilisin-like endoprotease with unique properties
    Biochem J (1997) 321, 587-593. PubMed  Europe PubMed  PMC  EPMC  I
    13. 1996
  13. Ivy,G.O., Roopsingh,R., Kanai,S., Ohta,M., Sato,Y. and Kitani,K.
    Leupeptin causes an accumulation of lipofuscin-like substances and other signs of aging in kidneys of young rats: further evidence for the protease inhibitor model of aging
    Ann N Y Acad Sci (1996) 786, 12-23. PubMed  Europe PubMed  I
  14. Kurinov,I.V. and Harrison,R.W.
    Two crystal structures of the leupeptin-trypsin complex
    Protein Sci (1996) 5, 752-758. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    15. 1995
  15. Kim,I.S. and Lee,K.J.
    Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13
    Microbiology (Reading, Engl.) (1995) 141, 1017-1025. PubMed  Europe PubMed  I
    16. 1993
  16. Savory,P.J. and Rivett,A.J.
    Leupeptin-binding site(s) in the mammalian multicatalytic proteinase complex
    Biochem J (1993) 289, 45-48. PubMed  Europe PubMed  PMC  EPMC  I
  17. Schroder,E., Phillips,C., Garman,E., Harlos,K. and Crawford,C.
    X-ray crystallographic structure of a papain-leupeptin complex
    FEBS Lett (1993) 315, 38-42. PubMed  Europe PubMed DOI  S  I
    18. 1988
  18. Saino,T., Someno,T., Ishii,S., Aoyagi,T. and Umezawa,H.
    Protease-inhibitory activities of leupeptin analogues
    J Antibiot (Tokyo) (1988) 41, 220-225. PubMed  Europe PubMed  I
    19. 1987
  19. Takahashi,S., Kato,H., Takahashi,A., Noguchi,T. and Naito,H.
    Mode of action of bestatin and leupeptin to induce the accumulation of acid soluble peptides in rat liver in vivo and the properties of the accumulated peptides. The important role of bestatin- and leupeptin-sensitive proteases in the protein degradation pathway in vivo
    Int J Biochem (1987) 19, 401-412. PubMed  Europe PubMed  I
    20. 1983
  20. Wilk,S. and Orlowski,M.
    Evidence that pituitary cation-sensitive neutral endopeptidase is a multicatalytic protease complex
    J Neurochem (1983) 40, 842-849. PubMed  Europe PubMed  I
    21. 1982
  21. Baici,A. and Gyger-Marazzi,M.
    The slow, tight-binding inhibition of cathepsin B by leupeptin. A hysteretic effect
    Eur J Biochem (1982) 129, 33-41. PubMed  Europe PubMed  I
  22. Hussain,M., Ozawa,Y., Ichihara,S. and Mizushima,S.
    Signal peptide digestion in Escherichia coli. Effect of protease inhibitors on hydrolysis of the cleaved signal peptide of the major outer-membrane lipoprotein
    Eur J Biochem (1982) 129, 233-239. PubMed  Europe PubMed  I
  23. Umezawa,H.
    Low-molecular-weight enzyme inhibitors of microbial origin
    Annu Rev Microbiol (1982) 36, 75-99. PubMed  Europe PubMed DOI  V  I
    24. 1981
  24. Suzuki,K., Tsuji,S. and Ishiura,S.
    Effect of Ca2+ on the inhibition of calcium-activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives
    FEBS Lett (1981) 136, 119-122. PubMed  Europe PubMed DOI  I
    25. 1977
  25. Umezawa,H. and Aoyagi,T.
    Activities of proteinase inhibitors of microbial origin
     (1977) , 637-662.  I
    26. 1973
  26. Fritz,H., Forg-Brey,B. and Umezawa,H.
    Leupeptin and antipain. Strong competitive inhibitors of sperm acrosomal proteinase (boar acrosin) and kallikreins from porcine organs (pancreas, submand. glands, urine)
    Hoppe Seylers Z Physiol Chem (1973) 354, 1304-1306. PubMed  Europe PubMed  I
    27. 1969
  27. Aoyagi,T., Takeuchi,T., Matsuzaki,A., Kawamura,K., Kondo,S., Hamada,M., Maeda,K. and Umezawa,H.
    Leupeptins, new protease inhibitors from Actinomycetes
    J Antibiot (Tokyo) (1969) 22, 283-286. PubMed  Europe PubMed  I
  28. Aoyagi,T., Miyata,S., Nanbo,M., Kojima,F., Matsuzaki,M., Ishizuka,M., Takeuchi,T. and Umezawa,H.
    Biological activities of leupeptins
    J Antibiot (Tokyo) (1969) 22, 558-568. PubMed  Europe PubMed  I
  29. Kawamura,K., Kondo,S.I., Maeda,K. and Umezawa,H.
    Structures and syntheses of leupeptins Pr-LL and Ac-LL
    Chem Pharm Bull (Tokyo) (1969) 17, 1902-1909.  I

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