Small-molecule inhibitor: ZD-8321
Inhibition
- History
- ZD8321 was described by Veale et al. (1997) as a potent, orally-bioavailable inhibitor of neutrophil elastase.
- Peptidases inhibited
- Neutrophil elastase (Ki 13 nM), pancreatic elastase: Ki 149 nM). Inhibition of other peptidases tested was negligible (Veale et al., 1997).
- Mechanism
- Inhibition is reversible.
- Pharmaceutical relevance
- Neutrophil elastase is regarded as a therapeutic target for a variety of conditions.
Chemistry
- Structure
![[ZD-8321 (S01.131 inhibitor) structure ]](/merops/smi/structures/zd8321.gif)
- Chemical/biochemical name
- N-methoxycarbonyl-Val-Pro-Val-trifluoromethane
