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Literature for K777 (C01.075 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, T Target, I Inhibitor, E Expression. To select only the references relevant to a single topic, click the link above. See explanation.)

    2020
  1. Jilkova,A., Horn,M. and Mares,M.
    Structural and functional characterization of Schistosoma mansoni cathepsin B1
    Methods Mol Biol (2020) 2151, 145-158. PubMed  Europe PubMed DOI  E  S  I
    2. 2019
  2. Kammer,L.M., Lipp,B. and Opatz,T.
    Photoredox alkenylation of carboxylic acids and peptides: synthesis of covalent enzyme inhibitors
    J Org Chem (2019) 84, 2379-2392. PubMed  Europe PubMed DOI  I
    3. 2018
  3. Zyserman,I., Mondal,D., Sarabia,F., McKerrow,J.H., Roush,W.R. and Debnath,A.
    Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri
    Exp Parasitol (2018) 188, 36-41. PubMed  Europe PubMed DOI  I
    4. 2016
  4. Kiemele,E.R., Wathier,M., Bichler,P. and Love,J.A.
    Total synthesis of K777: successful application of transition-metal-catalyzed alkyne hydrothiolation toward the modular synthesis of a potent cysteine protease inhibitor
    Org Lett (2016) 18, 492-495. PubMed  Europe PubMed DOI  I
    5. 2015
  5. Steverding,D.
    Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors
    Exp Parasitol (2015) 151-152C, 28-33. PubMed  Europe PubMed DOI  I
  6. Zhou,Y., Vedantham,P., Lu,K., Agudelo,J., Carrion,R., Jr., Nunneley,J.W., Barnard,D., Pohlmann,S., McKerrow,J.H., Renslo,A.R. and Simmons,G.
    Protease inhibitors targeting coronavirus and filovirus entry
    Antiviral Res (2015) 116, 76-84. PubMed  Europe PubMed DOI  I
    7. 2013
  7. Choy,J.W., Bryant,C., Calvet,C.M., Doyle,P.S., Gunatilleke,S.S., Leung,S.S., Ang,K.K., Chen,S., Gut,J., Oses-Prieto,J.A., Johnston,J.B., Arkin,M.R., Burlingame,A.L., Taunton,J., Jacobson,M.P., McKerrow,J.M., Podust,L.M. and Renslo,A.R.
    Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target
    Beilstein J Org Chem (2013) 9, 15-25. PubMed  Europe PubMed DOI  PMC  EPMC  I
  8. Dunny,E., Doherty,W., Evans,P., Malthouse,J.P., Nolan,D. and Knox,A.J.
    Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation
    J Med Chem (2013) 56, 6638-6650. PubMed  Europe PubMed DOI  I
  9. Ndao,M., Nath-Chowdhury,M., Sajid,M., Marcus,V., Mashiyama,S.T., Sakanari,J., Chow,E., Mackey,Z., Land,K.M., Jacobson,M.P., Kalyanaraman,C., McKerrow,J.H., Arrowood,M.J. and Caffrey,C.R.
    A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection
    Antimicrob Agents Chemother (2013) 57, 6063-6073. PubMed  Europe PubMed DOI  I
    10. 2012
  10. Cobo,E.R., Reed,S.L. and Corbeil,L.B.
    Effect of vinyl sulfone inhibitors of cysteine proteinases on Tritrichomonas foetus infection
    Int J Antimicrob Agents (2012) 39, 259-262. PubMed  Europe PubMed DOI  I
  11. Lee,G.M., Balouch,E., Goetz,D.H., Lazic,A., McKerrow,J.H. and Craik,C.S.
    Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy
    Biochemistry (2012) 51, 10087-10098. PubMed  Europe PubMed DOI  E  S  I
  12. Vermeire,J.J., Lantz,L.D. and Caffrey,C.R.
    Cure of hookworm infection with a cysteine protease inhibitor
    PLoS Negl Trop Dis (2012) 6, e1680-e1680. PubMed  Europe PubMed DOI  PMC  EPMC  I
  13. Yang,P.Y., Wang,M., He,C.Y. and Yao,S.Q.
    Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei
    Chem Commun (Camb) (2012) 48, 835-837. PubMed  Europe PubMed DOI  I
    14. 2011
  14. Jilkova,A., Rezacova,P., Lepsik,M., Horn,M., Vachova,J., Fanfrlik,J., Brynda,J., McKerrow,J.H., Caffrey,C.R. and Mares,M.
    Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni
    J Biol Chem (2011) 286, 35770-35781. PubMed  Europe PubMed DOI  S  I
    15. 2009
  15. Caffrey,C.R. and Steverding,D.
    Kinetoplastid papain-like cysteine peptidases
    Mol Biochem Parasitol (2009) 167, 12-19. PubMed  Europe PubMed DOI  I
  16. Kerr,I.D., Lee,J.H., Farady,C.J., Marion,R., Rickert,M., Sajid,M., Pandey,K.C., Caffrey,C.R., Legac,J., Hansell,E., McKerrow,J.H., Craik,C.S., Rosenthal,P.J. and Brinen,L.S.
    Vinyl sulfones as antiparasitic agents and a structural basis for drug design
    J Biol Chem (2009) 284, 25697-25703. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    17. 2007
  17. [YEAR:9-1-2007]Abdulla,M.H., Lim,K.C., Sajid,M., McKerrow,J.H. and Caffrey,C.R.
    Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor
    PLoS Medicine (9-1-2007) 4, e14-e14. PubMed  Europe PubMed DOI  PMC  EPMC  T  I
  18. Doyle,P.S., Zhou,Y.M., Engel,J.C. and McKerrow,J.H.
    A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection
    Antimicrob Agents Chemother (2007) 51, 3932-3939. PubMed  Europe PubMed DOI  PMC  EPMC  I
  19. Melendez-Lopez,S.G., Herdman,S., Hirata,K., Choi,M.H., Choe,Y., Craik,C., Caffrey,C.R., Hansell,E., Chavez-Munguia,B., Chen,Y.T., Roush,W.R., McKerrow,J., Eckmann,L., Guo,J., Stanley,S.L., Jr. and Reed,S.L.
    Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model
    Eukaryot Cell (2007) 6, 1130-1136. PubMed  Europe PubMed DOI  PMC  EPMC  I
    20. 2006
  20. [YEAR:2-10-2006]Nikolskaia,O.V., de,A.L., Kim,Y.V., Lonsdale-Eccles,J.D., Fukuma,T., Scharfstein,J. and Grab,D.J.
    Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease
    J Clin Invest (2-10-2006) 116, 2739-2747. PubMed  Europe PubMed DOI  I
    21. 2005
  21. Barr,S.C., Warner,K.L., Kornreic,B.G., Piscitelli,J., Wolfe,A., Benet,L. and McKerrow,J.H.
    A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi
    Antimicrob Agents Chemother (2005) 49, 5160-5161. PubMed  Europe PubMed DOI  PMC  EPMC  I
    22. 2000
  22. Jacobsen,W., Christians,U. and Benet,L.Z.
    In vitro evaluation of the disposition of a novel cysteine protease inhibitor
    Drug Metab Dispos (2000) 28, 1343-1351. PubMed  Europe PubMed  I
    23. 1998
  23. [YEAR:17-8-1998]Engel,J.C., Doyle,P.S., Hsieh,I. and McKerrow,J.H.
    Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection
    J Exp Med (17-8-1998) 188, 725-734. PubMed  Europe PubMed DOI  PMC  EPMC  I
    24. 1995
  24. Palmer,J.T., Rasnick,D., Klaus,J.L. and Bromme,D.
    Vinyl sulfones as mechanism-based cysteine protease inhibitors
    J Med Chem (1995) 38, 3193-3196. PubMed  Europe PubMed DOI  I

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