Literature for OM99-2 (A01.004 inhibitor)

(Topics flags: S Structure, A Assay, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2013
1. De Simone,A., Mancini,F., Real Fernandez,F., Rovero,P., Bertucci,C. and Andrisano,V.
   Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors
   Anal Bioanal Chem405, 827-835. PubMed  Europe PubMed DOI  I
2010
2. Niu,Y., Wang,Y., Zou,X., Yang,X., Ma,C., Lu,Y., Zhou,B., Yuan,Y., Du,G. and Xu,P.
   Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase
   Eur J Med Chem45, 2089-2094. PubMed  Europe PubMed DOI  I
2006
3. [YEAR:27-2-2006]Xiao,K., Li,X., Li,J., Ma,L., Hu,B., Yu,H., Fu,Y., Wang,R., Ma,Z., Qiu,B., Li,J., Hu,D., Wang,X. and Shen,J.
   Design, synthesis, and evaluation of Leu*Ala hydroxyethylene-based non-peptide beta-secretase (BACE) inhibitors
   Bioorg Med Chem14, 4535-4551. PubMed  Europe PubMed DOI  I
2005
4. [YEAR:3-1-2005]Ghosh,A.K., Devasamudram,T., Hong,L., DeZutter,C., Xu,X., Weerasena,V., Koelsch,G., Bilcer,G. and Tang,J.
   Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase)
   Bioorg Med Chem Lett15, 15-20. PubMed  Europe PubMed DOI  I
5. [YEAR:11-8-2005]Hanessian,S., Yun,H., Hou,Y., Yang,G., Bayrakdarian,M., Therrien,E., Moitessier,N., Roggo,S., Veenstra,S., Tintelnot-Blomley,M., Rondeau,J.M., Ostermeier,C., Strauss,A., Ramage,P., Paganetti,P., Neumann,U. and Betschart,C.
   Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
   J Med Chem48, 5175-5190. PubMed  Europe PubMed DOI  I
2003
6. [YEAR:23-10-2003]John,V., Beck,J.P., Bienkowski,M.J., Sinha,S. and Heinrikson,R.L.
   Human beta-secretase (BACE) and BACE inhibitors
   J Med Chem46, 4625-4630. PubMed  Europe PubMed DOI  V  I
7. [YEAR:1-8-2003]Kennedy,M.E., Wang,W., Song,L., Lee,J., Zhang,L., Wong,G., Wang,L. and Parker,E.
   Measuring human beta-secretase (BACE1) activity using homogeneous time-resolved fluorescence
   Anal Biochem319, 49-55. PubMed  Europe PubMed DOI  A  I
8. [YEAR:31-12-2003]Park,H. and Lee,S.
   Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design
   J Am Chem Soc125, 16416-16422. PubMed  Europe PubMed DOI  I
9. [YEAR:14-2-2003]Toulokhonova,L., Metzler,W.J., Witmer,M.R., Copeland,R.A. and Marcinkeviciene,J.
   Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism
   J Biol Chem278, 4582-4589. PubMed  Europe PubMed DOI  I
10. [YEAR:22-5-2003]Tounge,B.A. and Reynolds,C.H.
    Calculation of the binding affinity of beta-secretase inhibitors using the linear interaction energy method
    J Med Chem46, 2074-2082. PubMed  Europe PubMed DOI  I
2002
11. Hong,L., Turner,R.T., III, Koelsch,G., Ghosh,A.K. and Tang,J.
    Memapsin 2 (beta-secretase) as a therapeutic target
    Biochem Soc Trans30, 530-534. PubMed  Europe PubMed DOI  I
12. [YEAR:10-9-2002]Hong,L., Turner,R.T., III, Koelsch,G., Shin,D., Ghosh,A.K. and Tang,J.
    Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3
    Biochemistry41, 10963-10967. PubMed  Europe PubMed DOI  S  I
2001
13. [YEAR:30-8-2001]Ghosh,A.K., Bilcer,G., Harwood,C., Kawahama,R., Shin,D., Hussain,K.A., Hong,L., Loy,J.A., Nguyen,C., Koelsch,G., Ermolieff,J. and Tang,J.
    Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase)
    J Med Chem44, 2865-2868. PubMed  Europe PubMed DOI  I
14. [YEAR:28-8-2001]Turner,R.T., III, Koelsch,G., Hong,L., Castenheira,P., Ghosh,A. and Tang,J.
    Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design
    Biochemistry40, 10001-10006. PubMed  Europe PubMed DOI  I
2000
15. [YEAR:12-4-2000]Ghosh,A.K., Shin,D.W., Downs,D., Koelsch,G., Lin,X.L., Ermolieff,J. and Tang,J.
    Design of potent inhibitors for human brain memapsin 2 (beta-secretase)
    J Am Chem Soc122, 3522-3523.  I
16. [YEAR:6-10-2000]Hong,L., Koelsch,G., Lin,X.L., Wu,S.L., Terzyan,S., Ghosh,A.K., Zhang,X.C. and Tang,J.
    Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor
    Science290, 150-153. PubMed  Europe PubMed DOI  S  I