Structure for OM99-2 (A01.004 inhibitor)
| PDB | Organism | Resolution | Comment |
|---|---|---|---|
| 1FKN_A | Homo sapiens | 1.90 Å | protease domain; complex with Glu-Val-Asn-leucinol-2-methyl-propionyl-Ala-Glu-Phe inhibitor |
| One monomer of the dimer is shown. Active site residues are shown in ball-and-stick representation: Asp93 and Asp289 in pink, and Tyr132 in green. The peptide inhibitor OM99-2 is shown in grey in ball-and-stick representation. | |||
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| TERTIARY STRUCTURE DATA | ||||||||
|---|---|---|---|---|---|---|---|---|
| Comment | Resolution | PDB | PDBe | SCOP | CATH | PDBSum | Proteopedia | Reference |
| BACE1 g.p. (Homo sapiens) ( Homo sapiens) | ||||||||
| protease domain; complex with Glu-Val-Asn-leucinol-2-methyl-propionyl-Ala-Glu-Phe inhibitor | 1.90 Å | 1FKN | 1FKN | 1FKN | 1FKN | 1FKN | 1FKN | Hong et al., 2000 |
| complex with inhibitor OM99-2 at pH 5.0 | 2.50 Å | 2ZHR | 2ZHR | 2ZHR | 2ZHR | 2ZHR | 2ZHR | Shimizu et al., 2008 |
