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Literature for pepstatin (A01.001 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Maurer,A. and Kalbacher,H.
    Pepstatin pull-down at high pH is a powerful tool for detection and analysis of napsin A
    Biochem Biophys Res Commun (2019) 515, 145-148. PubMed  Europe PubMed DOI  I
  2. Zoia,M.A.P., Azevedo,F.V.P., Vecchi,L., Mota,S.T.S., Rodovalho,V.R., Cordeiro,A.O., Correia,L.I.V., Silva,A.C.A., Avila,V.M.R., Araujo,T.G. and Goulart,L.R.
    Inhibition of triple-negative breast cancer cell aggressiveness by cathepsin D blockage: role of annexin A1
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI  I
    3. 2018
  3. Arodola,O.A. and Soliman,M.E.
    Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors
    Future Med Chem (2018) 10, 5-26. PubMed  Europe PubMed DOI  I
    4. 2017
  4. Wilkinson,M.C., Nightingale,D.J.H., Harrison,R.A. and Wagstaff,S.C.
    Isolation and characterization of renin-like aspartic-proteases from Echis ocellatus venom
    Toxicon (2017) 137, 92-94. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Bedi,R.K., Patel,C., Mishra,V., Xiao,H., Yada,R.Y. and Bhaumik,P.
    Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
    Sci Rep (2016) 6, 31420-31420. PubMed  Europe PubMed DOI  I
  6. Cocchiaro,P., Fox,C., Tregidgo,N.W., Howarth,R., Wood,K.M., Situmorang,G.R., Pavone,L.M., Sheerin,N.S. and Moles,A.
    Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
    Sci Rep (2016) 6, 27112-27112. PubMed  Europe PubMed DOI  PMC  EPMC  I
  7. Fox,C., Cocchiaro,P., Oakley,F., Howarth,R., Callaghan,K., Leslie,J., Luli,S., Wood,K.M., Genovese,F., Sheerin,N.S. and Moles,A.
    Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease
    Sci Rep (2016) 6, 20101-20101. PubMed  Europe PubMed DOI  I
    8. 2015
  8. Hu,H.Y., Lim,N.H., Ding-Pfennigdorff,D., Saas,J., Wendt,K.U., Ritzeler,O., Nagase,H., Plettenburg,O., Schultz,C. and Nazare,M.
    DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis
    Bioconjug Chem (2015) 26, 383-388. PubMed  Europe PubMed DOI  I
  9. Jones SK Jr, Clarke,S.C., Craik,C.S. and Bennett,R.J.
    Evolutionary selection on barrier activity: Bar1 is an aspartyl protease with novel substrate specificity
    MBio (2015) 6, e01604-e01615. PubMed  Europe PubMed DOI  P  I
  10. Oliveira,C.S., Pereira,H., Alves,S., Castro,L., Baltazar,F., Chaves,S.R., Preto,A. and Corte-Real,M.
    Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria
    Cell Death Dis (2015) 6, e1788-e1788. PubMed  Europe PubMed DOI  T  I
    11. 2013
  11. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.
    Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
    Biochem Pharmacol (2013) 85, 881-887. PubMed  Europe PubMed DOI  I
  12. Maynadier,M., Vezenkov,L.L., Amblard,M., Martin,V., Gandreuil,C., Vaillant,O., Gary-Bobo,M., Basile,I., Hernandez,J.F., Garcia,M. and Martinez,J.
    Dipeptide mimic oligomer transporter mediates intracellular delivery of cathepsin D inhibitors: a potential target for cancer therapy
    J Control Release (2013) 171, 251-257. PubMed  Europe PubMed DOI  I
  13. Menon,V. and Rao,M.
    Mechanistic insights into the inhibition of endo-beta 1,4 xyloglucan hydrolase by a classical aspartic protease inhibitor
    J Fluoresc (2013) 23, 311-321. PubMed  Europe PubMed DOI  I
  14. Santos,L.O., Garcia-Gomes,A.S., Catanho,M., Sodre,C.L., Santos,A.L.S., Branquinha,M.H. and D'Avila-Levy,C.M.
    Aspartic peptidases of human pathogenic trypanosomatids: perspectives and trends for chemotherapy
    Curr Med Chem (2013) 20, 3116-3133. PubMed  Europe PubMed DOI  U  I
    15. 2012
  15. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.
    Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease
    PLoS ONE (2012) 7, e32513-e32513. PubMed  Europe PubMed DOI  PMC  EPMC  I
  16. Mahapatra,R.K., Behera,N. and Naik,P.K.
    Molecular modeling and prediction of binding mode and relative binding affinity of Art-Qui-OH with P. falciparum histo-aspartic protease (HAP)
    Bioinformation (2012) 8, 827-833. PubMed  Europe PubMed DOI  PMC  EPMC  I
  17. Matuz,K., Motyan,J., Li,M., Wlodawer,A. and Tozser,J.
    Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin
    FEBS J (2012) 279, 3276-3286. PubMed  Europe PubMed DOI  I
  18. Sangenito,L.S., Goncalves,K.C., Abi-Chacra,E.A., Sodre,C.L., D'Avila-Levy,C.M., Branquinha,M.H. and Santos,A.L.
    Multiple effects of pepstatin A on Trypanosoma cruzi epimastigote forms
    Parasitol Res (2012) 110, 2533-2540. PubMed  Europe PubMed DOI  I
    19. 2011
  19. Bewley,M.A., Pham,T.K., Marriott,H.M., Noirel,J., Chu,H.P., Ow,S.Y., Ryazanov,A.G., Read,R.C., Whyte,M.K., Chain,B., Wright,P.C. and Dockrell,D.H.
    Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae
    Mol Cell Proteomics (2011) 10, M111.008193- PubMed  Europe PubMed DOI  I
  20. Li,M., Gustchina,A., Matuz,K., Tozser,J., Namwong,S., Goldfarb,N.E., Dunn,B.M. and Wlodawer,A.
    Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease
    FEBS J (2011) 278, 4413-4424. PubMed  Europe PubMed DOI  S  I
    21. 2009
  21. Dostal,J., Brynda,J., Hruskova-Heidingsfeldova,O., Sieglova,I., Pichova,I. and Rezacova,P.
    The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A
    J Struct Biol (2009) 167, 145-152. PubMed  Europe PubMed DOI  S  I
    22. 2008
  22. Nascimento,A.S., Krauchenco,S., Golubev,A.M., Gustchina,A., Wlodawer,A. and Polikarpov,I.
    Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A
    J Mol Biol (2008) 382, 763-778. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    23. 2007
  23. Zaidi,N., Burster,T., Sommandas,V., Herrmann,T., Boehm,B.O., Driessen,C., Voelter,W. and Kalbacher,H.
    A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A
    Biochem Biophys Res Commun (2007) 364, 243-249. PubMed  Europe PubMed DOI  I
    24. 2006
  24. [YEAR:3-7-2006]Athauda,S.B., Yoshioka,K., Shiba,T. and Takahashi,K.
    Isolation and characterization of recombinant Drosophila copia aspartic proteinase
    Biochem J (3-7-2006) 399, 535-542. PubMed  Europe PubMed DOI  I
  25. Free,P., Hurley,C.A., Kageyama,T., Chain,B.M. and Tabor,A.B.
    Mannose-pepstatin conjugates as targeted inhibitors of antigen processing
    Org Biomol Chem (2006) 4, 1817-1830. PubMed  Europe PubMed DOI  I
  26. Nagahama,K., Yamato,M., Nishio,H. and Takeuchi,K.
    Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats
    Dig Dis Sci (2006) 51, 303-309. PubMed  Europe PubMed DOI  I
    27. 2004
  27. Alexov,E.
    Calculating proton uptake/release and binding free energy taking into account ionization and conformation changes induced by protein-inhibitor association: application to plasmepsin, cathepsin D and endothiapepsin-pepstatin complexes
    Proteins (2004) 56, 572-584. PubMed  Europe PubMed DOI  I
  28. [YEAR:1-10-2004]Blasi,E., Colombari,B., Orsi,C.F., Pinti,M., Troiano,L., Cossarizza,A., Esposito,R., Peppoloni,S., Mussini,C. and Neglia,R.
    The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans
    FEMS Immunol Med Microbiol (1-10-2004) 42, 187-195. PubMed  Europe PubMed DOI  I
  29. [YEAR:27-8-2004]Fujimoto,Z., Fujii,Y., Kaneko,S., Kobayashi,H. and Mizuno,H.
    Crystal structure of aspartic proteinase from Irpex lacteus in complex with inhibitor pepstatin
    J Mol Biol (27-8-2004) 341, 1227-1235. PubMed  Europe PubMed DOI  S  I
  30. [YEAR:29-10-2004]Prashar,V. and Hosur,M.V.
    1.8A X-ray structure of C95M/C1095F double mutant of tethered HIV-1 protease dimer complexed with acetyl pepstatin
    Biochem Biophys Res Commun (29-10-2004) 323, 1229-1235. PubMed  Europe PubMed DOI  S  I
    31. 2003
  31. [YEAR:7-3-2003]Kamitori,S., Ohtaki,A., Ino,H. and Takeuchi,M.
    Crystal structures of Aspergillus oryzae aspartic proteinase and its complex with an inhibitor pepstatin at 1.9A resolution
    J Mol Biol (7-3-2003) 326, 1503-1511. PubMed  Europe PubMed DOI  S  I
  32. Roberts,N.B. and Taylor,W.H.
    Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1, 3 and 5 (gastricsin) and pig pepsin A
    J Enzyme Inhib Med Chem (2003) 18, 209-217. PubMed  Europe PubMed DOI  I
    33. 2002
  33. [YEAR:30-8-2002]Tian,G., Sobotka-Briner,C.D., Zysk,J., Liu,X., Birr,C., Sylvester,M.A., Edwards,P.D., Scott,C.D. and Greenberg,B.D.
    Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines
    J Biol Chem (30-8-2002) 277, 31499-31505. PubMed  Europe PubMed DOI  I
    34. 2001
  34. [YEAR:17-7-2001]Evin,G., Sharples,R.A., Weidemann,A., Reinhard,F.B.M., Carbone,V., Culvenor,J.G., Holsinger,R.M.D., Sernee,M.F., Beyreuther,K. and Masters,C.L.
    Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
    Biochemistry (17-7-2001) 40, 8359-8368. PubMed  Europe PubMed DOI  I
    35. 2000
  35. [YEAR:16-3-2000]Chen,C.S., Chen,W.N., Zhou,M., Arttamangkul,S. and Haugland,R.P.
    Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy
    J Biochem Biophys Methods (16-3-2000) 42, 137-151. PubMed  Europe PubMed DOI  I
    36. 1992
  36. Szewczuk,Z., Rebholz,K.L. and Rich,D.H.
    Synthesis and biological activity of new conformationally restricted analogues of pepstatin
    Int J Pept Protein Res (1992) 40, 233-242. PubMed  Europe PubMed  I
    37. 1991
  37. McConnell,R.M., Frizzell,D., Camp,A., Evans,A., Jones,W. and Cagle,C.
    New pepstatin analogues: synthesis and pepsin inhibition
    J Med Chem (1991) 34, 2298-2300. PubMed  Europe PubMed  I
    38. 1990
  38. [YEAR:31-8-1990]Rittenhouse,J., Turon,M.C., Helfrich,R.J., Albrecht,K.S., Weigl,D., Simmer,R.L., Mordini,F., Erickson,J. and Kohlbrenner,W.E.
    Affinity purification of HIV-1 and HIV-2 proteases from recombinant E. coli strains using pepstatin-agarose
    Biochem Biophys Res Commun (31-8-1990) 171, 60-66. PubMed  Europe PubMed DOI  I
    39. 1989
  39. Conner,G.E.
    Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme
    Biochem J (1989) 263, 601-604. PubMed  Europe PubMed  PMC  EPMC  I
  40. Maibaum,J. and Rich,D.H.
    Synthesis of the novel pi-(benzyloxymethyl)-protected histidine analogue of statine. Inhibition of penicillopepsin by pepstatin-derived peptides containing different statine side-chain derivatives
    J Med Chem (1989) 32, 1571-1576. PubMed  Europe PubMed  I
    41. 1988
  41. Seelmeier,S., Schmidt,H., Turk,V. and von der Helm,K.
    Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A
    Proc Natl Acad Sci U S A (1988) 85, 6612-6616. PubMed  Europe PubMed  PMC  EPMC  I
    42. 1987
  42. Holladay,M.W., Salituro,F.G. and Rich,D.H.
    Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres
    J Med Chem (1987) 30, 374-383. PubMed  Europe PubMed  I
  43. [YEAR:15-10-1987]Katoh,I., Yasunaga,T., Ikawa,Y. and Yoshinaka,Y.
    Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor
    Nature (15-10-1987) 329, 654-656. PubMed  Europe PubMed DOI  I
    44. 1986
  44. Agarwal,N.S. and Rich,D.H.
    Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin
    J Med Chem (1986) 29, 2519-2524. PubMed  Europe PubMed  I
    45. 1985
  45. [YEAR:18-6-1985]Rich,D.H., Bernatowicz,M.S., Agarwal,N.S., Kawai,M., Salituro,F.G. and Schmidt,P.G.
    Inhibition of aspartic proteases by pepstatin and 3-methylstatine derivatives of pepstatin. Evidence for collected-substrate enzyme inhibition
    Biochemistry (18-6-1985) 24, 3165-3173. PubMed  Europe PubMed  I
  46. Rich,D.H.
    Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor
    J Med Chem (1985) 28, 263-273. PubMed  Europe PubMed  I
    47. 1984
  47. Yamato,S., Hirabayashi,Y. and Sugihara,H.
    An improved procedure for the histochemical demonstration of cathepsin D by the mercury-labeled pepstatin method
    Biotech Histochem (1984) 59, 113-120. DOI  I
    48. 1983
  48. Rich,D.H. and Salituro,F.G.
    Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin
    J Med Chem (1983) 26, 904-910. PubMed  Europe PubMed  I
    49. 1982
  49. [YEAR:21-12-1982]Bott,R., Subramanian,E. and Davies,D.R.
    Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5-A resolution
    Biochemistry (21-12-1982) 21, 6956-6962. PubMed  Europe PubMed  S  I
  50. James,M.N., Sielecki,A., Salituro,F., Rich,D.H. and Hofmann,T.
    Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin
    Proc Natl Acad Sci U S A (1982) 79, 6137-6141. PubMed  Europe PubMed  PMC  EPMC  S  I
  51. Rich,D.H., Bernatowicz,M.S. and Schmidt,P.G.
    Direct carbon-13 NMR evidence for a tetrahedral intermediate in the binding of a pepstatin analog to porcine pepsin
    J Am Chem Soc (1982) 104, 3535-3536.  I
  52. Rich,D.H. and Bernatowicz,M.S.
    Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin
    J Med Chem (1982) 25, 791-795. PubMed  Europe PubMed  I
  53. [YEAR:11-2-1982]Rich,D.H., Boparai,A.S. and Bernatowicz,M.S.
    Synthesis of a 3-oxo-4(S)-amino acid analog of pepstatin. A new inhibitor of carboxyl (acid) proteases
    Biochem Biophys Res Commun (11-2-1982) 104, 1127-1133. PubMed  Europe PubMed  I
  54. [YEAR:21-12-1982]Schmidt,P.G., Bernatowicz,M.S. and Rich,D.H.
    Pepstatin binding to pepsin. Enzyme conformation changes monitored by nuclear magnetic resonance
    Biochemistry (21-12-1982) 21, 6710-6716. PubMed  Europe PubMed  I
  55. [YEAR:13-4-1982]Schmidt,P.G., Bernatowicz,M.S. and Rich,D.H.
    Spin-labeled pepstatin binding to pepsin. A study by electron spin resonance and nuclear magnetic resonance
    Biochemistry (13-4-1982) 21, 1830-1835. PubMed  Europe PubMed  I
    56. 1981
  56. [YEAR:1-8-1981]Eid,M., Evin,G., Castro,B., Menard,J. and Corvol,P.
    New renin inhibitors homologous with pepstatin
    Biochem J (1-8-1981) 197, 465-471. PubMed  Europe PubMed  PMC  EPMC  I
  57. [YEAR:1-12-1981]Matthews,I.T., Decker,R.S. and Knight,C.G.
    Bimane-labelled pepstatin, a fluorescent probe for the subcellular location of cathepsin D
    Biochem J (1-12-1981) 199, 611-617. PubMed  Europe PubMed  PMC  EPMC  I
  58. Suzuki,F., Nakamura,Y., Nagata,Y., Ohsawa,T. and Murakami,K.
    A rapid and large-scale isolation of renin from mouse submaxillary gland by pepstatin-aminohexyl-agarose affinity chromatography
    J Biochem (1981) 89, 1107-1112. PubMed  Europe PubMed  I
    59. 1980
  59. [YEAR:10-7-1980]Nakatani,H., Tsuchiya,M., Morita,T., Ohki,S. and Hiromi,K.
    Binding of Streptomyces pepsin inhibitor (acetyl-pepstatin) with chymosin (rennin)
    Biochim Biophys Acta (10-7-1980) 614, 144-150. PubMed  Europe PubMed  I
  60. Rich,D.H., Sun,E.T. and Ulm,E.
    Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin
    J Med Chem (1980) 23, 27-33. PubMed  Europe PubMed  I
  61. Rich,D.H. and Sun,E.T.
    Mechanism of inhibition of pepsin by pepstatin. Effect of inhibitor structure on dissociation constant and time-dependent inhibition
    Biochem Pharmacol (1980) 29, 2205-2212. PubMed  Europe PubMed DOI  I
    62. 1979
  62. Ackerman,S.K. and Douglas,S.D.
    Pepstatin A - a human leukocyte chemoattractant
    Clin Immunol Immunopathol (1979) 14, 244-250. PubMed  Europe PubMed  I
    63. 1978
  63. Kobayashi,H. and Murakami,K.
    Rapid and large scale isolation of chymosin (rennin) by pepstatin-aminohexylagarose
    Agric Biol Chem (1978) 42, 2227-2231. DOI  I
  64. Miyazaki,M., Okunishi,H., Komori,T. and Yamamoto,K.
    Renin inhibitory effect of N-acetyl-pepstatin
    Jpn J Pharmacol (1978) 28, 171-174. PubMed  Europe PubMed  I
    65. 1977
  65. [YEAR:24-1-1977]Rich,D.H., Sun,E. and Singh,J.
    Synthesis of dideoxy-pepstatin. Mechanism of inhibition of porcine pepsin
    Biochem Biophys Res Commun (24-1-1977) 74, 762-767. PubMed  Europe PubMed  I
    66. 1976
  66. Knight,C.G. and Barrett,A.J.
    Interaction of human cathepsin D with the inhibitor pepstatin
    Biochem J (1976) 155, 117-125. PubMed  Europe PubMed  PMC  EPMC  I
  67. [YEAR:25-11-1976]Marciniszyn,J., Jr., Hartsuck,J.A. and Tang,J.
    Mode of inhibition of acid proteases by pepstatin
    J Biol Chem (25-11-1976) 251, 7088-7094. PubMed  Europe PubMed  I
  68. Takahashi,K. and Chang,W.J.
    The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin
    J Biochem (1976) 80, 497-506. PubMed  Europe PubMed  I
    69. 1975
  69. Nakatani,H., Hiromi,K., Satoi,S., Oda,K. and Murao,S.
    Studies on the interaction between Streptomyces pepsin inhibitor and several acid proteinases by means of a zinc(II)-dye complex as a probe
    Biochim Biophys Acta (1975) 391, 415-421. PubMed  Europe PubMed  I
    70. 1974
  70. Kokubu,T., Hiwada,K., Nagasaka,Y. and Yamamura,Y.
    Effect of several proteinase inhibitors on renin reaction
    Jpn Circ J (1974) 38, 955-958. DOI  I
  71. Kunimoto,S., Aoyagi,T., Nishizawa,R., Komai,T. and Takeuchi,T.
    Mechanism of inhibition of pepsin by pepstatin. II
    J Antibiot (Tokyo) (1974) 27, 413-418. PubMed  Europe PubMed  I
  72. Takahashi,K., Chang,W. and Ko,J.
    Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin
    J Biochem (1974) 76, 897-899. PubMed  Europe PubMed  I
    73. 1973
  73. [YEAR:15-8-1973]Corvol,P., Devaux,C. and Menard,J.
    Pepstatin, an inhibitor for renin purification by affinity chromatography
    FEBS Lett (15-8-1973) 34, 189-192. PubMed  Europe PubMed DOI  I
  74. Kinoshita,M., Aburaki,S., Hagiwara,A. and Imai,J.
    Letter: Absolute configuration of 4-amino-3-hydroxy-6-methylheptanoic acid present in pepstatin A and stereospecific synthesis of all four isomers
    J Antibiot (Tokyo) (1973) 26, 249-251. PubMed  Europe PubMed  I
  75. Morishima,H., Takita,T. and Umezawa,H.
    Letter: Synthesis of 4-amino-3-hydroxy-6-methylheptanoic acid, an amine component of pepstatin
    J Antibiot (Tokyo) (1973) 26, 115-116. PubMed  Europe PubMed  I
  76. Umezawa,H., Miyano,T., Murakami,T., Takita,T., Aoyagi,T., Takeuchi,T., Naganawa,H. and Morishima,H.
    Hydroxypepstatin, a new pepstatin produced by Streptomyces
    J Antibiot (Tokyo) (1973) 26, 615-617. PubMed  Europe PubMed  I
    77. 1972
  77. Aoyagi,T., Morishima,H., Nishizawa,R., Kunimoto,S., Takeuchi,T. and Umezawa,H.
    Biological activity of pepstatins, pepstanone A and partial peptides on pepsin, cathepsin D and renin
    J Antibiot (Tokyo) (1972) 25, 689-694. PubMed  Europe PubMed  I
  78. Barrett,A.J. and Dingle,J.T.
    The inhibition of tissue acid proteinases by pepstatin
    Biochem J (1972) 127, 439-441. PubMed  Europe PubMed  PMC  EPMC  I
  79. Gross,F., Lazar,J. and Orth,H.
    Inhibition of the renin-angiotensinogen reaction by pepstatin
    Science (1972) 175, 656-656. PubMed  Europe PubMed  I
  80. Kunimoto,S., Aoyagi,T., Morishima,H., Takeuchi,T. and Umezawa,H.
    Mechanism of inhibition of pepsin by pepstatin
    J Antibiot (Tokyo) (1972) 25, 251-255. PubMed  Europe PubMed  I
  81. Miller,R.P., Poper,C.H., Wilson,C.W. and DeVito,E.
    Renin inhibition by pepstatin
    Biochem Pharmacol (1972) 21, 2941-2944. PubMed  Europe PubMed  I
  82. Miyano,T., Tomiyasu,M., Iizuka,H., Tomisaka,S., Takita,T., Aoyagi,T. and Umezawa,H.
    New pepstatins, pepstatins B and C, and pepstanone A, produced by Streptomyces
    J Antibiot (Tokyo) (1972) 25, 489-491. PubMed  Europe PubMed  I
  83. Woessner,J.F., Jr.
    Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D
    Biochem Biophys Res Commun (1972) 47, 965-970. PubMed  Europe PubMed  I
    84. 1971
  84. Aoyagi,T., Kunimoto,S., Morishima,H., Takeuchi,T. and Umezawa,H.
    Effect of pepstatin on acid proteases
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