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Literature for pepstatin (A01.001 inhibitor)

Summary Structure Literature

(Topics flags: S Structure, T Target, P Specificity, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

    2019
  1. Maurer,A. and Kalbacher,H.
    Pepstatin pull-down at high pH is a powerful tool for detection and analysis of napsin A
    Biochem Biophys Res Commun515, 145-148. PubMed  Europe PubMed DOI  I
  2. Zoia,M.A.P., Azevedo,F.V.P., Vecchi,L., Mota,S.T.S., Rodovalho,V.R., Cordeiro,A.O., Correia,L.I.V., Silva,A.C.A., Avila,V.M.R., Araujo,T.G. and Goulart,L.R.
    Inhibition of triple-negative breast cancer cell aggressiveness by cathepsin D blockage: role of annexin A1
    Int J Mol Sci20, PubMed  Europe PubMed DOI  I
    3. 2018
  3. Arodola,O.A. and Soliman,M.E.
    Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors
    Future Med Chem10, 5-26. PubMed  Europe PubMed DOI  I
    4. 2017
  4. Wilkinson,M.C., Nightingale,D.J.H., Harrison,R.A. and Wagstaff,S.C.
    Isolation and characterization of renin-like aspartic-proteases from Echis ocellatus venom
    Toxicon137, 92-94. PubMed  Europe PubMed DOI  I
    5. 2016
  5. Bedi,R.K., Patel,C., Mishra,V., Xiao,H., Yada,R.Y. and Bhaumik,P.
    Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
    Sci Rep6, 31420-31420. PubMed  Europe PubMed DOI  I
  6. Cocchiaro,P., Fox,C., Tregidgo,N.W., Howarth,R., Wood,K.M., Situmorang,G.R., Pavone,L.M., Sheerin,N.S. and Moles,A.
    Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
    Sci Rep6, 27112-27112. PubMed  Europe PubMed DOI  I
    7. 2015
  7. Hu,H.Y., Lim,N.H., Ding-Pfennigdorff,D., Saas,J., Wendt,K.U., Ritzeler,O., Nagase,H., Plettenburg,O., Schultz,C. and Nazare,M.
    DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis
    Bioconjug Chem26, 383-388. PubMed  Europe PubMed DOI  I
  8. Jones SK Jr, Clarke,S.C., Craik,C.S. and Bennett,R.J.
    Evolutionary selection on barrier activity: Bar1 is an aspartyl protease with novel substrate specificity
    MBio6, e01604-e01615. PubMed  Europe PubMed DOI  P  I
  9. Oliveira,C.S., Pereira,H., Alves,S., Castro,L., Baltazar,F., Chaves,S.R., Preto,A. and Corte-Real,M.
    Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria
    Cell Death Dis6, e1788-e1788. PubMed  Europe PubMed DOI  T  I
    10. 2013
  10. Cadicamo,C.D., Mortier,J., Wolber,G., Hell,M., Heinrich,I.E., Michel,D., Semlin,L., Berger,U., Korting,H.C., Holtje,H.D., Koksch,B. and Borelli,C.
    Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans
    Biochem Pharmacol85, 881-887. PubMed  Europe PubMed DOI  I
  11. Maynadier,M., Vezenkov,L.L., Amblard,M., Martin,V., Gandreuil,C., Vaillant,O., Gary-Bobo,M., Basile,I., Hernandez,J.F., Garcia,M. and Martinez,J.
    Dipeptide mimic oligomer transporter mediates intracellular delivery of cathepsin D inhibitors: a potential target for cancer therapy
    J Control Release171, 251-257. PubMed  Europe PubMed DOI  I
    12. 2012
  12. Aoki,W., Kitahara,N., Miura,N., Morisaka,H., Yamamoto,Y., Kuroda,K. and Ueda,M.
    Candida albicans possesses Sap7 as a pepstatin A-insensitive secreted aspartic protease
    PLoS ONE7, e32513-e32513. PubMed  Europe PubMed DOI  I
  13. Mahapatra,R.K., Behera,N. and Naik,P.K.
    Molecular modeling and prediction of binding mode and relative binding affinity of Art-Qui-OH with P. falciparum histo-aspartic protease (HAP)
    Bioinformation8, 827-833. PubMed  Europe PubMed DOI  I
  14. Matuz,K., Motyan,J., Li,M., Wlodawer,A. and Tozser,J.
    Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin
    FEBS J279, 3276-3286. PubMed  Europe PubMed DOI  I
    15. 2011
  15. Li,M., Gustchina,A., Matuz,K., Tozser,J., Namwong,S., Goldfarb,N.E., Dunn,B.M. and Wlodawer,A.
    Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease
    FEBS J278, 4413-4424. PubMed  Europe PubMed DOI  S  I
    16. 2009
  16. Dostal,J., Brynda,J., Hruskova-Heidingsfeldova,O., Sieglova,I., Pichova,I. and Rezacova,P.
    The crystal structure of the secreted aspartic protease 1 from Candida parapsilosis in complex with pepstatin A
    J Struct Biol167, 145-152. PubMed  Europe PubMed DOI  S  I
    17. 2008
  17. Nascimento,A.S., Krauchenco,S., Golubev,A.M., Gustchina,A., Wlodawer,A. and Polikarpov,I.
    Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A
    J Mol Biol382, 763-778. PubMed  Europe PubMed DOI  S  I
    18. 2006
  18. [YEAR:3-7-2006]Athauda,S.B., Yoshioka,K., Shiba,T. and Takahashi,K.
    Isolation and characterization of recombinant Drosophila copia aspartic proteinase
    Biochem J399, 535-542. PubMed  Europe PubMed DOI  I
  19. Nagahama,K., Yamato,M., Nishio,H. and Takeuchi,K.
    Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats
    Dig Dis Sci51, 303-309. PubMed  Europe PubMed DOI  I
    20. 2004
  20. Alexov,E.
    Calculating proton uptake/release and binding free energy taking into account ionization and conformation changes induced by protein-inhibitor association: application to plasmepsin, cathepsin D and endothiapepsin-pepstatin complexes
    Proteins56, 572-584. PubMed  Europe PubMed DOI  I
  21. [YEAR:27-8-2004]Fujimoto,Z., Fujii,Y., Kaneko,S., Kobayashi,H. and Mizuno,H.
    Crystal structure of aspartic proteinase from Irpex lacteus in complex with inhibitor pepstatin
    J Mol Biol341, 1227-1235. PubMed  Europe PubMed DOI  S  I
  22. [YEAR:29-10-2004]Prashar,V. and Hosur,M.V.
    1.8A X-ray structure of C95M/C1095F double mutant of tethered HIV-1 protease dimer complexed with acetyl pepstatin
    Biochem Biophys Res Commun323, 1229-1235. PubMed  Europe PubMed DOI  S  I
    23. 2003
  23. [YEAR:7-3-2003]Kamitori,S., Ohtaki,A., Ino,H. and Takeuchi,M.
    Crystal structures of Aspergillus oryzae aspartic proteinase and its complex with an inhibitor pepstatin at 1.9A resolution
    J Mol Biol326, 1503-1511. PubMed  Europe PubMed DOI  S  I
  24. Roberts,N.B. and Taylor,W.H.
    Comparative pepstatin inhibition studies on individual human pepsins and pepsinogens 1, 3 and 5 (gastricsin) and pig pepsin A
    J Enzyme Inhib Med Chem18, 209-217. PubMed  Europe PubMed DOI  I
    25. 2002
  25. [YEAR:30-8-2002]Tian,G., Sobotka-Briner,C.D., Zysk,J., Liu,X., Birr,C., Sylvester,M.A., Edwards,P.D., Scott,C.D. and Greenberg,B.D.
    Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines
    J Biol Chem277, 31499-31505. PubMed  Europe PubMed DOI  I
    26. 2001
  26. [YEAR:17-7-2001]Evin,G., Sharples,R.A., Weidemann,A., Reinhard,F.B.M., Carbone,V., Culvenor,J.G., Holsinger,R.M.D., Sernee,M.F., Beyreuther,K. and Masters,C.L.
    Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease
    Biochemistry40, 8359-8368. PubMed  Europe PubMed DOI  I
    27. 1989
  27. Conner,G.E.
    Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme
    Biochem J263, 601-604. PubMed  Europe PubMed  I
    28. 1988
  28. Seelmeier,S., Schmidt,H., Turk,V. and von der Helm,K.
    Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A
    Proc Natl Acad Sci U S A85, 6612-6616. PubMed  Europe PubMed  I
    29. 1987
  29. [YEAR:15-10-1987]Katoh,I., Yasunaga,T., Ikawa,Y. and Yoshinaka,Y.
    Inhibition of retroviral protease activity by an aspartyl proteinase inhibitor
    Nature329, 654-656. PubMed  Europe PubMed DOI  I
    30. 1986
  30. Agarwal,N.S. and Rich,D.H.
    Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin
    J Med Chem29, 2519-2524. PubMed  Europe PubMed  I
    31. 1982
  31. [YEAR:21-12-1982]Bott,R., Subramanian,E. and Davies,D.R.
    Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5-A resolution
    Biochemistry21, 6956-6962. PubMed  Europe PubMed  S  I
  32. James,M.N., Sielecki,A., Salituro,F., Rich,D.H. and Hofmann,T.
    Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin
    Proc Natl Acad Sci U S A79, 6137-6141. PubMed  Europe PubMed  S  I
    33. 1981
  33. [YEAR:1-8-1981]Eid,M., Evin,G., Castro,B., Menard,J. and Corvol,P.
    New renin inhibitors homologous with pepstatin
    Biochem J197, 465-471. PubMed  Europe PubMed  I
    34. 1980
  34. [YEAR:10-7-1980]Nakatani,H., Tsuchiya,M., Morita,T., Ohki,S. and Hiromi,K.
    Binding of Streptomyces pepsin inhibitor (acetyl-pepstatin) with chymosin (rennin)
    Biochim Biophys Acta614, 144-150. PubMed  Europe PubMed  I
  35. Rich,D.H. and Sun,E.T.
    Mechanism of inhibition of pepsin by pepstatin. Effect of inhibitor structure on dissociation constant and time-dependent inhibition
    Biochem Pharmacol29, 2205-2212. PubMed  Europe PubMed DOI  I
    36. 1978
  36. Miyazaki,M., Okunishi,H., Komori,T. and Yamamoto,K.
    Renin inhibitory effect of N-acetyl-pepstatin
    Jpn J Pharmacol28, 171-174. PubMed  Europe PubMed  I
    37. 1976
  37. Knight,C.G. and Barrett,A.J.
    Interaction of human cathepsin D with the inhibitor pepstatin
    Biochem J155, 117-125. PubMed  Europe PubMed  I
  38. [YEAR:25-11-1976]Marciniszyn,J., Jr., Hartsuck,J.A. and Tang,J.
    Mode of inhibition of acid proteases by pepstatin
    J Biol Chem251, 7088-7094. PubMed  Europe PubMed  I
  39. Takahashi,K. and Chang,W.J.
    The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin
    J Biochem80, 497-506. PubMed  Europe PubMed  I
    40. 1975
  40. Nakatani,H., Hiromi,K., Satoi,S., Oda,K. and Murao,S.
    Studies on the interaction between Streptomyces pepsin inhibitor and several acid proteinases by means of a zinc(II)-dye complex as a probe
    Biochim Biophys Acta391, 415-421. PubMed  Europe PubMed  I
    41. 1974
  41. Takahashi,K., Chang,W. and Ko,J.
    Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin
    J Biochem76, 897-899. PubMed  Europe PubMed  I
    42. 1972
  42. Barrett,A.J. and Dingle,J.T.
    The inhibition of tissue acid proteinases by pepstatin
    Biochem J127, 439-441. PubMed  Europe PubMed  I
  43. Gross,F., Lazar,J. and Orth,H.
    Inhibition of the renin-angiotensinogen reaction by pepstatin
    Science175, 656-656. PubMed  Europe PubMed  I
  44. Kunimoto,S., Aoyagi,T., Morishima,H., Takeuchi,T. and Umezawa,H.
    Mechanism of inhibition of pepsin by pepstatin
    J Antibiot (Tokyo)25, 251-255. PubMed  Europe PubMed  I
  45. Miyano,T., Tomiyasu,M., Iizuka,H., Tomisaka,S., Takita,T., Aoyagi,T. and Umezawa,H.
    New pepstatins, pepstatins B and C, and pepstanone A, produced by Streptomyces
    J Antibiot (Tokyo)25, 489-491. PubMed  Europe PubMed  I
  46. Woessner,J.F., Jr.
    Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D
    Biochem Biophys Res Commun47, 965-970. PubMed  Europe PubMed  I
    47. 1970
  47. Umezawa,H., Aoyagi,T., Morishima,H., Matsuzaki,M., Hamada,M. and Takeuchi,T.
    Pepstatin, a new pepsin inhibitor produced by actinomycetes
    J Antibiot (Tokyo)23, 259-262. PubMed  Europe PubMed  I

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