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Literature for fumagillin (M24.002 inhibitor)

Summary Structure Literature Inhibits

(Topics flags: S Structure, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2011
  1. Ma,A.C., Fung,T.K., Lin,R.H., Chung,M.I., Yang,D., Ekker,S.C. and Leung,A.Y.
    Methionine aminopeptidase 2 is required for HSC initiation and proliferation
    Blood (2011) 118, 5448-5457. PubMed  Europe PubMed DOI  I
    2. 2010
  2. Yamaguchi,J. and Hayashi,Y.
    Syntheses of fumagillin and ovalicin
    Chemistry (2010) 16, 3884-3901. PubMed  Europe PubMed DOI  V  I
    3. 2009
  3. Alvarado,J.J., Nemkal,A., Sauder,J.M., Russell,M., Akiyoshi,D.E., Shi,W., Almo,S.C. and Weiss,L.M.
    Structure of a microsporidian methionine aminopeptidase type 2 complexed with fumagillin and TNP-470
    Mol Biochem Parasitol (2009) 168, 158-167. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  4. Arico-Muendel,C.C., Benjamin,D.R., Caiazzo,T.M., Centrella,P.A., Contonio,B.D., Cook,C.M., Doyle,E.G., Hannig,G., Labenski,M.T., Searle,L.L., Lind,K., Morgan,B.A., Olson,G., Paradise,C.L., Self,C., Skinner,S.R., Sluboski,B., Svendsen,J.L., Thompson,C.D., Westlin,W. and White,K.F.
    Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2
    J Med Chem (2009) 52, 8047-8056. PubMed  Europe PubMed DOI  I
  5. Chen,X., Xie,S., Bhat,S., Kumar,N., Shapiro,T.A. and Liu,J.O.
    Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo
    Chem Biol (2009) 16, 193-202. PubMed  Europe PubMed DOI  I
    6. 2006
  6. Didier,P.J., Phillips,J.N., Kuebler,D.J., Nasr,M., Brindley,P.J., Stovall,M.E., Bowers,L.C. and Didier,E.S.
    Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo
    Antimicrob Agents Chemother (2006) 50, 2146-2155. PubMed  Europe PubMed DOI  PMC  EPMC  I
    7. 2004
  7. [YEAR:9-8-2004]Asami,Y., Kakeya,H., Onose,R., Chang,Y.H., Toi,M. and Osada,H.
    RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2
    Tetrahedron (9-8-2004) 60, 7085-7091. DOI  I
  8. [YEAR:8-10-2004]Boxem,M., Tsai,C.W., Zhang,Y., Saito,R.M. and Liu,J.O.
    The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation
    FEBS Lett (8-10-2004) 576, 245-250. PubMed  Europe PubMed DOI  K  I
  9. [YEAR:5-3-2004]Brdlik,C.M. and Crews,C.M.
    A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases
    J Biol Chem (5-3-2004) 279, 9475-9480. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. [YEAR:1-5-2004]Kim,S., LaMontagne,K., Sabio,M., Sharma,S., Versace,R.W., Yusuff,N. and Phillips,P.E.
    Depletion of methionine aminopeptidase 2 does not alter cell response to fumagillin or bengamides
    Cancer Res (1-5-2004) 64, 2984-2987. PubMed  Europe PubMed DOI  I
    11. 2003
  11. [YEAR:1-8-2003]Bontems,F., le Floch,P., Duffieux,F., Biderre,C., Peyret,P. and Lallemand,J.Y.
    Homology modeling and calculation of the cobalt cluster charges of the Encephalitozoon cuniculi methionine aminopeptidase, a potential target for drug design
    Biophys Chem (1-8-2003) 105, 29-43. PubMed  Europe PubMed DOI  I
    12. 2000
  12. [YEAR:3-1-2000]Han,C.K., Ahn,S.K., Choi,N.S., Hong,R.K., Moon,S.K., Chun,H.S., Lee,S.J., Kim,J.W., Hong,C.I., Kim,D., Yoon,J.H. and No,K.T.
    Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
    Bioorg Med Chem Lett (3-1-2000) 10, 39-43. PubMed  Europe PubMed DOI  I
  13. Kruger,E.A. and Figg,W.D.
    TNP-470: an angiogenesis inhibitor in clinical development for cancer
    Expert Opin Investig Drugs (2000) 9, 1383-1396. PubMed  Europe PubMed DOI  I
  14. Kwon,J.Y., Jeong,H.W., Kim,H.K., Kang,K.H., Chang,Y.H., Bae,K.S., Choi,J.D., Lee,U.C., Son,K.H. and Kwon,B.M.
    cis-Fumagillin, a new methionine aminopeptidase (type 2) inhibitor produced by Penicillium sp. F2757
    J Antibiot (Tokyo) (2000) 53, 799-806. PubMed  Europe PubMed  I
  15. Wang,J., Lou,P. and Henkin,J.
    Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases
    J Cell Biochem (2000) 77, 465-473. PubMed  Europe PubMed DOI  I
  16. [YEAR:6-6-2000]Zhang,Y., Griffith,E.C., Sage,J., Jacks,T. and Liu,J.O.
    Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
    Proc Natl Acad Sci U S A (6-6-2000) 97, 6427-6432. PubMed  Europe PubMed  PMC  EPMC  I
    17. 1999
  17. Stadler,W.M., Kuzel,T., Shapiro,C., Sosman,J., Clark,J. and Vogelzang,N.J.
    Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma
    J Clin Oncol (1999) 17, 2541-2545. PubMed  Europe PubMed  I
    18. 1998
  18. Dezube,B.J., Von Roenn,J.H., Holden-Wiltse,J., Cheung,T.W., Remick,S.C., Cooley,T.P., Moore,J., Sommadossi,J.P., Shriver,S.L., Suckow,C.W. and Gill,P.S.
    Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team
    J Clin Oncol (1998) 16, 1444-1449. PubMed  Europe PubMed  I
  19. [YEAR:22-12-1998]Griffith,E.C., Su,Z., Niwayama,S., Ramsay,C.A., Chang,Y.H. and Liu,J.O.
    Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2
    Proc Natl Acad Sci U S A (22-12-1998) 95, 15183-15188. PubMed  Europe PubMed DOI  PMC  EPMC  I
  20. [YEAR:13-11-1998]Liu,S., Widom,J., Kemp,C.W., Crews,C.M. and Clardy,J.
    Structure of human methionine aminopeptidase-2 complexed with fumagillin
    Science (13-11-1998) 282, 1324-1327. PubMed  Europe PubMed  S  I
  21. [YEAR:13-10-1998]Lowther,W.T., McMillen,D.A., Orville,A.M. and Matthews,B.W.
    The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase
    Proc Natl Acad Sci U S A (13-10-1998) 95, 12153-12157. PubMed  Europe PubMed DOI  PMC  EPMC  I
    22. 1997
  22. Kudelka,A.P., Levy,T., Verschraegen,C.F., Edwards,C.L., Piamsomboon,S., Termrungruanglert,W., Freedman,R.S., Kaplan,A.L., Kieback,D.G., Meyers,C.A., Jaeckle,K.A., Loyer,E., Steger,M., Mante,R., Mavligit,G., Killian,A., Tang,R.A., Gutterman,J.U. and Kavanagh,J.J.
    A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix
    Clin Cancer Res (1997) 3, 1501-1505. PubMed  Europe PubMed  I
  23. Sin,N., Meng,L., Wang,M.Q., Wen,J.J., Bornmann,W.G. and Crews,C.M.
    The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2
    Proc Natl Acad Sci U S A (1997) 94, 6099-6103. PubMed  Europe PubMed DOI  PMC  EPMC  I
    24. 1990
  24. [YEAR:6-12-1990]Ingber,D., Fujita,T., Kishimoto,S., Sudo,K., Kanamaru,T., Brem,H. and Folkman,J.
    Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
    Nature (6-12-1990) 348, 555-557. PubMed  Europe PubMed DOI  I

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