Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I32.004: XIAP caspase inhibitor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

(Topics flags: S Structure, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,N., Wang,S., Liu,J., Zhang,P., Chang,Y., Li,H., Zhao,K., Liu,Y., Huang,M., Hu,Y., Lin,Z., Lu,Y., Jiang,G., Chen,W., Huang,C. and Jin,H.<br>XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1<br>Cell Death Dis (2025) 16, 205-205. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Acharya,R., Deb,P.K., Venugopala,K.N. and Pattanayak,S.P.<br>An Azomethine Derivative, BCS3, Targets XIAP and cIAP1/2 to Arrest Breast Cancer Progression Through MDM2-p53 and Bcl-2-Caspase Signaling Modulation<br>Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2022
  3. Hanifeh,M. and Ataei,F.<br>XIAP as a multifaceted molecule in Cellular Signaling<br>Apoptosis (2022) 27, 441-453. PubMed  Europe PubMed DOI  V
  4. Qiao,H., Tian,Y., Huo,Y. and Man,H.Y.<br>Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice<br>iScience (2022) 25, 104595-104595. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Saha,G., Sarkar,S., Mohanta,P.S., Kumar,K., Chakrabarti,S., Basu,M. and Ghosh,M.K.<br>USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma<br>Oncogene (2022) 41, 5061-5075. PubMed  Europe PubMed DOI
    6. 2018
  6. Yun,S.E., Nam,M.K. and Rhim,H.<br>Quantitative biochemical characterization and biotechnological production of caspase modulator, XIAP: therapeutic implications for apoptosis-associated diseases<br>Biochim Biophys Acta (2018) 1862, 1602-1611. PubMed  Europe PubMed DOI
    7. 2017
  7. Tamanini,E., Buck,I.M., Chessari,G., Chiarparin,E., Day,J.E.H., Frederickson,M., Griffiths-Jones,C.M., Hearn,K., Heightman,T.D., Iqbal,A., Johnson,C.N., Lewis,E.J., Martins,V., Peakman,T., Reader,M., Rich,S.J., Ward,G.A., Williams,P.A. and Wilsher,N.E.<br>Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP)<br>J Med Chem (2017) 60, 4611-4625. PubMed  Europe PubMed DOI
    8. 2015
  8. Elsawy,M.A., Tikhonova,I.G., Martin,L. and Walker,B.<br>Smac-derived aza-peptide as an aminopeptidase-resistant XIAP BIR3 antagonist<br>Protein Pept Lett (2015) 22, 836-843. PubMed  Europe PubMed
  9. Seigal,B.A., Connors,W.H., Fraley,A., Borzilleri,R.M., Carter,P.H., Emanuel,S.L., Fargnoli,J., Kim,K., Lei,M., Naglich,J.G., Pokross,M.E., Posy,S.L., Shen,H., Surti,N., Talbott,R., Zhang,Y. and Terrett,N.K.<br>The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity<br>J Med Chem (2015) 58, 2855-2861. PubMed  Europe PubMed DOI  S
  10. Wu,W., Wan,O.W. and Chung,K.K.<br>S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function<br>Apoptosis (2015) 20, 491-499. PubMed  Europe PubMed DOI
    11. 2013
  11. Guicciardi,M.E. and Gores,G.J.<br>Unshackling caspase-7 for cancer therapy<br>J Clin Invest (2013) 123, 3706-3708. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Lin,Y.F., Lai,T.C., Chang,C.K., Chen,C.L., Huang,M.S., Yang,C.J., Liu,H.G., Dong,J.J., Chou,Y.A., Teng,K.H., Chen,S.H., Tian,W.T., Jan,Y.H., Hsiao,M. and Liang,P.H.<br>Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies<br>J Clin Invest (2013) 123, 3861-3875. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Unsain,N., Higgins,J.M., Parker,K.N., Johnstone,A.D. and Barker,P.A.<br>XIAP regulates caspase activity in degenerating axons<br>Cell Rep (2013) 4, 751-763. PubMed  Europe PubMed DOI
    14. 2011
  14. Hornle,M., Peters,N., Thayaparasingham,B., Vorsmann,H., Kashkar,H. and Kulms,D.<br>Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis<br>Oncogene (2011) 30, 575-587. PubMed  Europe PubMed DOI
    15. 2010
  15. Abhari,B.A. and Davoodi,J.<br>BIR2 domain of XIAP plays a marginal role in inhibition of executioner caspases<br>Int J Biol Macromol (2010) 46, 337-341. PubMed  Europe PubMed DOI
  16. Nakamura,T., Wang,L., Wong,C.C., Scott,F.L., Eckelman,B.P., Han,X., Tzitzilonis,C., Meng,F., Gu,Z., Holland,E.A., Clemente,A.T., Okamoto,S.I., Salvesen,G.S., Riek,R., Yates,J.R., III and Lipton,S.A.<br>Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death<br>Mol Cell (2010) 39, 184-195. PubMed  Europe PubMed DOI
    17. 2009
  17. Cossu,F., Mastrangelo,E., Milani,M., Sorrentino,G., Lecis,D., Delia,D., Manzoni,L., Seneci,P., Scolastico,C. and Bolognesi,M.<br>Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2<br>Biochem Biophys Res Commun (2009) 378, 162-167. PubMed  Europe PubMed DOI  S
  18. Cossu,F., Milani,M., Mastrangelo,E., Vachette,P., Servida,F., Lecis,D., Canevari,G., Delia,D., Drago,C., Rizzo,V., Manzoni,L., Seneci,P., Scolastico,C. and Bolognesi,M.<br>Structural basis for bivalent Smac-mimetics recognition in the IAP protein family<br>J Mol Biol (2009) 392, 630-644. PubMed  Europe PubMed DOI  S
    19. 2008
  19. Abhari,B.A. and Davoodi,J.<br>A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases<br>J Mol Biol (2008) 381, 645-654. PubMed  Europe PubMed DOI
  20. Cillessen,S.A., Reed,J.C., Welsh,K., Pinilla,C., Houghten,R., Hooijberg,E., Deurhof,J., Castricum,K.C., Kortman,P., Hess,C.J., Ossenkoppele,G.J., Meijer,C.J. and Oudejans,J.J.<br>Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells<br>Blood (2008) 111, 369-375. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Mastrangelo,E., Cossu,F., Milani,M., Sorrentino,G., Lecis,D., Delia,D., Manzoni,L., Drago,C., Seneci,P., Scolastico,C., Rizzo,V. and Bolognesi,M.<br>Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles<br>J Mol Biol (2008) 384, 673-689. PubMed  Europe PubMed DOI  S
  22. Nikolovska-Coleska,Z., Meagher,J.L., Jiang,S., Yang,C.Y., Qiu,S., Roller,P.P., Stuckey,J.A. and Wang,S.<br>Interaction of a cyclic, bivalent smac mimetic with the X-linked inhibitor of apoptosis protein<br>Biochemistry (2008) 47, 9811-9824. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Paulsen,M., Ussat,S., Jakob,M., Scherer,G., Lepenies,I., Schutze,S., Kabelitz,D. and Adam-Klages,S.<br>Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes<br>Eur J Immunol (2008) 38, 1979-1987. PubMed  Europe PubMed DOI
  24. Sun,H., Stuckey,J.A., Nikolovska-Coleska,Z., Qin,D., Meagher,J.L., Qiu,S., Lu,J., Yang,C.Y., Saito,N.G. and Wang,S.<br>Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP)<br>J Med Chem (2008) 51, 7169-7180. PubMed  Europe PubMed DOI  PMC  EPMC  S
    25. 2007
  25. Davoodi,J., Mohammad-Gholi,A., Es-Haghi,A. and Mackenzie,A.<br>W323S variant of Xiap-Bir3 binds to SMAC but not caspase-9<br>J Biochem (2007) 141, 293-299. PubMed  Europe PubMed DOI
  26. Denault,J.B., Eckelman,B.P., Shin,H., Pop,C. and Salvesen,G.S.<br>Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9<br>Biochem J (2007) 405, 11-19. PubMed  Europe PubMed DOI
  27. Gao,Z., Tian,Y., Wang,J., Yin,Q., Wu,H., Li,Y.M. and Jiang,X.<br>A dimeric Smac/Diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo<br>J Biol Chem (2007) 282, 30718-30727. PubMed  Europe PubMed DOI
  28. Lin,S.C., Huang,Y., Lo,Y.C., Lu,M. and Wu,H.<br>Crystal structure of the BIR1 domain of XIAP in two crystal forms<br>J Mol Biol (2007) 372, 847-854. PubMed  Europe PubMed DOI  PMC  EPMC  S
  29. Lu,M., Lin,S.C., Huang,Y., Kang,Y.J., Rich,R., Lo,Y.C., Myszka,D., Han,J. and Wu,H.<br>XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization<br>Mol Cell (2007) 26, 689-702. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Wang,X.H., Hu,J., Du,J. and Klein,J.D.<br>X-Chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice<br>Gene Ther (2007) 14, 711-720. PubMed  Europe PubMed DOI  U
  31. Wist,A.D., Gu,L., Riedl,S.J., Shi,Y. and McLendon,G.L.<br>Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP<br>Bioorg Med Chem (2007) 15, 2935-2943. PubMed  Europe PubMed DOI  S
    32. 2006
  32. Eckelman,B.P., Salvesen,G.S. and Scott,F.L.<br>Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family<br>EMBO Rep (2006) 7, 988-994. PubMed  Europe PubMed DOI
    33. 2005
  33. [YEAR:1-2-2005]Carter,B.Z., Gronda,M., Wang,Z., Welsh,K., Pinilla,C., Andreeff,M., Schober,W.D., Nefzi,A., Pond,G.R., Mawji,I.A., Houghten,R.A., Ostresh,J., Brandwein,J., Minden,M.D., Schuh,A.C., Wells,R.A., Messner,H., Chun,K., Reed,J.C. and Schimmer,A.D.<br>Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells<br>Blood (1-2-2005) 105, 4043-4050. PubMed  Europe PubMed DOI  PMC  EPMC
  34. [YEAR:13-1-2005]Scott,F.L., Denault,J.B., Riedl,S.J., Shin,H., Renatus,M. and Salvesen,G.S.<br>XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs<br>EMBO J (13-1-2005) 24, 645-655. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2004
  35. [YEAR:24-6-2004]Dohi,T., Okada,K., Xia,F., Wilford,C.E., Samuel,T., Welsh,K., Marusawa,H., Zou,H., Armstrong,R., Matsuzawa,S., Salvesen,G.S., Reed,J.C. and Altieri,D.C.<br>An IAP-IAP complex inhibits apoptosis<br>J Biol Chem (24-6-2004) 279, 34087-34090. PubMed  Europe PubMed DOI
  36. [YEAR:29-12-2004]Lewis,J., Burstein,E., Reffey,S.B., Bratton,S.B., Roberts,A.B. and Duckett,C.S.<br>Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis<br>J Biol Chem (29-12-2004) 279, 9023-9029. PubMed  Europe PubMed DOI
  37. Schimmer,A.D., Welsh,K., Pinilla,C., Wang,Z., Krajewska,M., Bonneau,M.J., Pedersen,I.M., Kitada,S., Scott,F.L., Bailly-Maitre,B., Glinsky,G., Scudiero,D., Sausville,E., Salvesen,G., Nefzi,A., Ostresh,J.M., Houghten,R.A. and Reed,J.C.<br>Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity<br>Cancer Cell (2004) 5, 25-35. PubMed  Europe PubMed DOI
  38. [YEAR:12-8-2004]Sun,H., Nikolovska-Coleska,Z., Yang,C.Y., Xu,L., Tomita,Y., Krajewski,K., Roller,P.P. and Wang,S.<br>Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site<br>J Med Chem (12-8-2004) 47, 4147-4150. PubMed  Europe PubMed DOI
  39. [YEAR:27-8-2004]Wang,Z., Cuddy,M., Samuel,T., Welsh,K., Schimmer,A., Hanaii,F., Houghten,R., Pinilla,C. and Reed,J.C.<br>Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors<br>J Biol Chem (27-8-2004) 279, 48168-48176. PubMed  Europe PubMed DOI
    40. 2003
  40. Hell,K., Saleh,M., Crescenzo,G.D., O'Connor-McCourt,M.D. and Nicholson,D.W.<br>Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities<br>Cell Death Differ (2003) 10, 1234-1239. PubMed  Europe PubMed DOI
  41. [YEAR:21-7-2003]Kashkar,H., Haefs,C., Shin,H., Hamilton-Dutoit,S.J., Salvesen,G.S., Kronke,M. and Jurgensmeier,J.M.<br>XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells<br>J Exp Med (21-7-2003) 198, 341-347. PubMed  Europe PubMed DOI  PMC  EPMC
  42. [YEAR:24-11-2003]Potts,P.R., Singh,S., Knezek,M., Thompson,C.B. and Deshmukh,M.<br>Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis<br>J Cell Biol (24-11-2003) 163, 789-799. PubMed  Europe PubMed DOI  PMC  EPMC
  43. [YEAR:1-8-2003]Shin,H., Okada,K., Wilkinson,J.C., Solomon,K.M., Duckett,C.S., Reed,J.C. and Salvesen,G.S.<br>Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein<br>Biochem J (1-8-2003) 373, 965-971. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Shiozaki,E.N., Chai,J., Rigotti,D.J., Riedl,S.J., Li,P., Srinivasula,S.M., Alnemri,E.S., Fairman,R. and Shi,Y.<br>Mechanism of XIAP-mediated inhibition of caspase-9<br>Mol Cell (2003) 11, 519-527. PubMed  Europe PubMed DOI  S
  45. [YEAR:22-8-2003]Srinivasula,S.M., Gupta,S., Datta,P., Zhang,Z., Hegde,R., Cheong,N., Fernandes-Alnemri,T. and Alnemri,E.S.<br>Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2<br>J Biol Chem (22-8-2003) 278, 31469-31472. PubMed  Europe PubMed DOI
  46. [YEAR:18-4-2003]Tamm,I., Trepel,M., Cardo-Vila,M., Sun,Y., Welsh,K., Cabezas,E., Swatterthwait,A., Arap,W., Reed,J.C. and Pasqualini,R.<br>Peptides targeting caspase inhibitors<br>J Biol Chem (18-4-2003) 278, 14401-14405. PubMed  Europe PubMed DOI
  47. [YEAR:9-5-2003]Vaux,D.L. and Silke,J.<br>Mammalian mitochondrial IAP binding proteins<br>Biochem Biophys Res Commun (9-5-2003) 304, 499-504. PubMed  Europe PubMed DOI
    48. 2002
  48. [YEAR:4-1-2002]Hegde,R., Srinivasula,S.M., Zhang,Z., Wassell,R., Mukattash,R., Cilenti,L., Dubois,G., Lazebnik,Y., Zervos,A.S., Fernandes-Alnemri,T. and Alnemri,E.S.<br>Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction<br>J Biol Chem (4-1-2002) 277, 432-438. PubMed  Europe PubMed DOI
  49. Hofmann,H.S., Simm,A., Hammer,A., Silber,R.E. and Bartling,B.<br>Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer<br>J Cancer Res Clin Oncol (2002) 128, 554-560. PubMed  Europe PubMed DOI
  50. [YEAR:4-1-2002]Martins,L.M., Iaccarino,I., Tenev,T., Gschmeissner,S., Totty,N.F., Lemoine,N.R., Savopoulos,J., Gray,C.W., Creasy,C.L., Dingwall,C. and Downward,J.<br>The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif<br>J Biol Chem (4-1-2002) 277, 439-444. PubMed  Europe PubMed DOI
  51. [YEAR:20-3-2002]Sauerwald,T.M., Betenbaugh,M.J. and Oyler,G.A.<br>Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants<br>Biotechnol Bioeng (20-3-2002) 77, 704-716. PubMed  Europe PubMed DOI
  52. [YEAR:1-4-2002]Silke,J., Hawkins,C.J., Ekert,P.G., Chew,J., Day,C.L., Pakusch,M., Verhagen,A.M. and Vaux,D.L.<br>The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites<br>J Cell Biol (1-4-2002) 157, 115-124. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Stennicke,H.R., Ryan,C.A. and Salvesen,G.S.<br>Reprieval from execution: the molecular basis of caspase inhibition<br>Trends Biochem Sci (2002) 27, 94-101. PubMed  Europe PubMed DOI
  54. Van Loo,G., van Gurp,M., Depuydt,B., Srinivasula,S.M., Rodriguez,I., Alnemri,E.S., Gevaert,K., Vandekerckhove,J., Declercq,W. and Vandenabeele,P.<br>The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity<br>Cell Death Differ (2002) 9, 20-26. PubMed  Europe PubMed DOI
  55. [YEAR:4-1-2002]Verhagen,A.M., Silke,J., Ekert,P.G., Pakusch,M., Kaufmann,H., Connolly,L.M., Day,C.L., Tikoo,A., Burke,R., Wrobel,C., Moritz,R.L., Simpson,R.J. and Vaux,D.L.<br>HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins<br>J Biol Chem (4-1-2002) 277, 445-454. PubMed  Europe PubMed DOI
  56. [YEAR:5-4-2002]Vucic,D., Deshayes,K., Ackerly,H., Pisabarro,M.T., Kadkhodayan,S., Fairbrother,W.J. and Dixit,V.M.<br>SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)<br>J Biol Chem (5-4-2002) 277, 12275-12279. PubMed  Europe PubMed DOI
    57. 2001
  57. [YEAR:1-3-2001]Bratton,S.B., Walker,G., Srinivasula,S.M., Sun,X.M., Butterworth,M., Alnemri,E.S. and Cohen,G.M.<br>Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes<br>EMBO J (1-3-2001) 20, 998-1009. PubMed  Europe PubMed DOI  PMC  EPMC
  58. [YEAR:9-3-2001]Chai,J.J., Shiozaki,E., Srinivasula,S.M., Wu,Q., Dataa,P., Alnemri,E.S. and Shi,Y.G.<br>Structural basis of caspase-7 inhibition by XIAP<br>Cell (9-3-2001) 104, 769-780. PubMed  Europe PubMed  S  I
  59. [YEAR:9-3-2001]Huang,Y.H., Park,Y.C., Rich,R.L., Segal,D., Myszka,D.G. and Wu,H.<br>Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain<br>Cell (9-3-2001) 104, 781-790. PubMed  Europe PubMed  S
  60. [YEAR:9-3-2001]Riedl,S.J., Renatus,M., Schwarzenbacher,R., Zhou,Q., Sun,C., Fesik,S.W., Liddington,R.C. and Salvesen,G.S.<br>Structural basis for the inhibition of caspase-3 by XIAP<br>Cell (9-3-2001) 104, 791-800. PubMed  Europe PubMed  S
  61. [YEAR:1-3-2001]Srinivasula,S.M., Hegde,R., Saleh,A., Datta,P., Shiozaki,E., Chai,J., Lee,R.A., Robbins,P.D., Fernandes-Alnemri,T., Shi,Y. and Alnemri,E.S.<br>A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis<br>Nature (1-3-2001) 410, 112-116. PubMed  Europe PubMed DOI
  62. [YEAR:20-7-2001]Suzuki,Y., Nakabayashi,Y., Nakata,K., Reed,J.C. and Takahashi,R.<br>X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and-7 in distinct modes<br>J Biol Chem (20-7-2001) 276, 27058-27063. PubMed  Europe PubMed DOI
    63. 2000
  63. [YEAR:13-10-2000]Datta,R., Oki,E., Endo,K., Biedermann,V., Ren,J. and Kufe,D.<br>XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage<br>J Biol Chem (13-10-2000) 275, 31733-31738. PubMed  Europe PubMed DOI
  64. Deveraux,Q.L., Welsh,K. and Reed,J.C.<br>Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors<br>Methods Enzymol (2000) 322, 154-161. PubMed  Europe PubMed  V
  65. [YEAR:27-10-2000]Sun,C., Cai,M., Meadows,R.P., Xu,N., Gunasekera,A.H., Herrmann,J., Wu,J.C. and Fesik,S.W.<br>NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP<br>J Biol Chem (27-10-2000) 275, 33777-33781. PubMed  Europe PubMed DOI  S
    66. 1999
  66. [YEAR:1-10-1999]Deveraux,Q.L., Leo,E., Stennicke,H.R., Welsh,K., Salvesen,G.S. and Reed,J.C.<br>Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases<br>EMBO J (1-10-1999) 18, 5242-5251. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Sun,C., Cai,M., Gunasekera,A.H., Meadows,R.P., Wang,H., Chen,J., Zhang,H., Wu,W., Xu,N., Ng,S.C. and Fesik,S.W.<br>NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP<br>Nature (1999) 401, 818-822. PubMed  Europe PubMed DOI
    68. 1998
  68. [YEAR:15-4-1998]Deveraux,Q.L., Roy,N., Stennicke,H.R., Van Arsdale,T., Zhou,Q., Srinivasula,S.M., Alnemri,E.S., Salvesen,G.S. and Reed,J.C.<br>IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases<br>EMBO J (15-4-1998) 17, 2215-2223. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 1997
  69. [YEAR:17-7-1997]Deveraux,Q.L., Takahashi,R., Salvesen,G.S. and Reed,J.C.<br>X-linked IAP is a direct inhibitor of cell-death proteases<br>Nature (17-7-1997) 388, 300-304. PubMed  Europe PubMed DOI
  70. [YEAR:15-6-1997]Farahani,R., Fong,W.G., Korneluk,R.G. and MacKenzie,A.E.<br>Genomic organization and primary characterization of mIAP-3: the murine homologue of human X-linked IAP<br>Genomics (15-6-1997) 42, 514-518. PubMed  Europe PubMed DOI
    71. 1996
  71. [YEAR:1-11-1996]Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.<br>Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization<br>Genomics (1-11-1996) 37, 404-406. PubMed  Europe PubMed DOI
  72. Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.<br>Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors<br>Proc Natl Acad Sci U S A (1996) 93, 4974-4978. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use