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Literature for inhibitor I32.004: XIAP caspase inhibitor

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits Pharma

(Topics flags: S Structure, I Inhibitor, K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Sun,N., Wang,S., Liu,J., Zhang,P., Chang,Y., Li,H., Zhao,K., Liu,Y., Huang,M., Hu,Y., Lin,Z., Lu,Y., Jiang,G., Chen,W., Huang,C. and Jin,H.
    XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
    Cell Death Dis (2025) 16, 205-205. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2024
  2. Acharya,R., Deb,P.K., Venugopala,K.N. and Pattanayak,S.P.
    An Azomethine Derivative, BCS3, Targets XIAP and cIAP1/2 to Arrest Breast Cancer Progression Through MDM2-p53 and Bcl-2-Caspase Signaling Modulation
    Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2022
  3. Hanifeh,M. and Ataei,F.
    XIAP as a multifaceted molecule in Cellular Signaling
    Apoptosis (2022) 27, 441-453. PubMed  Europe PubMed DOI  V
  4. Qiao,H., Tian,Y., Huo,Y. and Man,H.Y.
    Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice
    iScience (2022) 25, 104595-104595. PubMed  Europe PubMed DOI  PMC  EPMC  K
  5. Saha,G., Sarkar,S., Mohanta,P.S., Kumar,K., Chakrabarti,S., Basu,M. and Ghosh,M.K.
    USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma
    Oncogene (2022) 41, 5061-5075. PubMed  Europe PubMed DOI
    6. 2018
  6. Yun,S.E., Nam,M.K. and Rhim,H.
    Quantitative biochemical characterization and biotechnological production of caspase modulator, XIAP: therapeutic implications for apoptosis-associated diseases
    Biochim Biophys Acta (2018) 1862, 1602-1611. PubMed  Europe PubMed DOI
    7. 2017
  7. Tamanini,E., Buck,I.M., Chessari,G., Chiarparin,E., Day,J.E.H., Frederickson,M., Griffiths-Jones,C.M., Hearn,K., Heightman,T.D., Iqbal,A., Johnson,C.N., Lewis,E.J., Martins,V., Peakman,T., Reader,M., Rich,S.J., Ward,G.A., Williams,P.A. and Wilsher,N.E.
    Discovery of a potent nonpeptidomimetic, small-molecule antagonist of cellular inhibitor of apoptosis protein 1 (cIAP1) and X-linked inhibitor of apoptosis protein (XIAP)
    J Med Chem (2017) 60, 4611-4625. PubMed  Europe PubMed DOI
    8. 2015
  8. Elsawy,M.A., Tikhonova,I.G., Martin,L. and Walker,B.
    Smac-derived aza-peptide as an aminopeptidase-resistant XIAP BIR3 antagonist
    Protein Pept Lett (2015) 22, 836-843. PubMed  Europe PubMed
  9. Seigal,B.A., Connors,W.H., Fraley,A., Borzilleri,R.M., Carter,P.H., Emanuel,S.L., Fargnoli,J., Kim,K., Lei,M., Naglich,J.G., Pokross,M.E., Posy,S.L., Shen,H., Surti,N., Talbott,R., Zhang,Y. and Terrett,N.K.
    The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity
    J Med Chem (2015) 58, 2855-2861. PubMed  Europe PubMed DOI  S
  10. Wu,W., Wan,O.W. and Chung,K.K.
    S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function
    Apoptosis (2015) 20, 491-499. PubMed  Europe PubMed DOI
    11. 2013
  11. Guicciardi,M.E. and Gores,G.J.
    Unshackling caspase-7 for cancer therapy
    J Clin Invest (2013) 123, 3706-3708. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Lin,Y.F., Lai,T.C., Chang,C.K., Chen,C.L., Huang,M.S., Yang,C.J., Liu,H.G., Dong,J.J., Chou,Y.A., Teng,K.H., Chen,S.H., Tian,W.T., Jan,Y.H., Hsiao,M. and Liang,P.H.
    Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies
    J Clin Invest (2013) 123, 3861-3875. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Unsain,N., Higgins,J.M., Parker,K.N., Johnstone,A.D. and Barker,P.A.
    XIAP regulates caspase activity in degenerating axons
    Cell Rep (2013) 4, 751-763. PubMed  Europe PubMed DOI
    14. 2011
  14. Hornle,M., Peters,N., Thayaparasingham,B., Vorsmann,H., Kashkar,H. and Kulms,D.
    Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis
    Oncogene (2011) 30, 575-587. PubMed  Europe PubMed DOI
    15. 2010
  15. Abhari,B.A. and Davoodi,J.
    BIR2 domain of XIAP plays a marginal role in inhibition of executioner caspases
    Int J Biol Macromol (2010) 46, 337-341. PubMed  Europe PubMed DOI
  16. Nakamura,T., Wang,L., Wong,C.C., Scott,F.L., Eckelman,B.P., Han,X., Tzitzilonis,C., Meng,F., Gu,Z., Holland,E.A., Clemente,A.T., Okamoto,S.I., Salvesen,G.S., Riek,R., Yates,J.R., III and Lipton,S.A.
    Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death
    Mol Cell (2010) 39, 184-195. PubMed  Europe PubMed DOI
    17. 2009
  17. Cossu,F., Mastrangelo,E., Milani,M., Sorrentino,G., Lecis,D., Delia,D., Manzoni,L., Seneci,P., Scolastico,C. and Bolognesi,M.
    Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
    Biochem Biophys Res Commun (2009) 378, 162-167. PubMed  Europe PubMed DOI  S
  18. Cossu,F., Milani,M., Mastrangelo,E., Vachette,P., Servida,F., Lecis,D., Canevari,G., Delia,D., Drago,C., Rizzo,V., Manzoni,L., Seneci,P., Scolastico,C. and Bolognesi,M.
    Structural basis for bivalent Smac-mimetics recognition in the IAP protein family
    J Mol Biol (2009) 392, 630-644. PubMed  Europe PubMed DOI  S
    19. 2008
  19. Abhari,B.A. and Davoodi,J.
    A mechanistic insight into SMAC peptide interference with XIAP-Bir2 inhibition of executioner caspases
    J Mol Biol (2008) 381, 645-654. PubMed  Europe PubMed DOI
  20. Cillessen,S.A., Reed,J.C., Welsh,K., Pinilla,C., Houghten,R., Hooijberg,E., Deurhof,J., Castricum,K.C., Kortman,P., Hess,C.J., Ossenkoppele,G.J., Meijer,C.J. and Oudejans,J.J.
    Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
    Blood (2008) 111, 369-375. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Mastrangelo,E., Cossu,F., Milani,M., Sorrentino,G., Lecis,D., Delia,D., Manzoni,L., Drago,C., Seneci,P., Scolastico,C., Rizzo,V. and Bolognesi,M.
    Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles
    J Mol Biol (2008) 384, 673-689. PubMed  Europe PubMed DOI  S
  22. Nikolovska-Coleska,Z., Meagher,J.L., Jiang,S., Yang,C.Y., Qiu,S., Roller,P.P., Stuckey,J.A. and Wang,S.
    Interaction of a cyclic, bivalent smac mimetic with the X-linked inhibitor of apoptosis protein
    Biochemistry (2008) 47, 9811-9824. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Paulsen,M., Ussat,S., Jakob,M., Scherer,G., Lepenies,I., Schutze,S., Kabelitz,D. and Adam-Klages,S.
    Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes
    Eur J Immunol (2008) 38, 1979-1987. PubMed  Europe PubMed DOI
  24. Sun,H., Stuckey,J.A., Nikolovska-Coleska,Z., Qin,D., Meagher,J.L., Qiu,S., Lu,J., Yang,C.Y., Saito,N.G. and Wang,S.
    Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP)
    J Med Chem (2008) 51, 7169-7180. PubMed  Europe PubMed DOI  PMC  EPMC  S
    25. 2007
  25. Davoodi,J., Mohammad-Gholi,A., Es-Haghi,A. and Mackenzie,A.
    W323S variant of Xiap-Bir3 binds to SMAC but not caspase-9
    J Biochem (2007) 141, 293-299. PubMed  Europe PubMed DOI
  26. Denault,J.B., Eckelman,B.P., Shin,H., Pop,C. and Salvesen,G.S.
    Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9
    Biochem J (2007) 405, 11-19. PubMed  Europe PubMed DOI
  27. Gao,Z., Tian,Y., Wang,J., Yin,Q., Wu,H., Li,Y.M. and Jiang,X.
    A dimeric Smac/Diablo peptide directly relieves caspase-3 inhibition by XIAP. Dynamic and cooperative regulation of XIAP by Smac/Diablo
    J Biol Chem (2007) 282, 30718-30727. PubMed  Europe PubMed DOI
  28. Lin,S.C., Huang,Y., Lo,Y.C., Lu,M. and Wu,H.
    Crystal structure of the BIR1 domain of XIAP in two crystal forms
    J Mol Biol (2007) 372, 847-854. PubMed  Europe PubMed DOI  PMC  EPMC  S
  29. Lu,M., Lin,S.C., Huang,Y., Kang,Y.J., Rich,R., Lo,Y.C., Myszka,D., Han,J. and Wu,H.
    XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization
    Mol Cell (2007) 26, 689-702. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Wang,X.H., Hu,J., Du,J. and Klein,J.D.
    X-Chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice
    Gene Ther (2007) 14, 711-720. PubMed  Europe PubMed DOI  U
  31. Wist,A.D., Gu,L., Riedl,S.J., Shi,Y. and McLendon,G.L.
    Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP
    Bioorg Med Chem (2007) 15, 2935-2943. PubMed  Europe PubMed DOI  S
    32. 2006
  32. Eckelman,B.P., Salvesen,G.S. and Scott,F.L.
    Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
    EMBO Rep (2006) 7, 988-994. PubMed  Europe PubMed DOI
    33. 2005
  33. [YEAR:1-2-2005]Carter,B.Z., Gronda,M., Wang,Z., Welsh,K., Pinilla,C., Andreeff,M., Schober,W.D., Nefzi,A., Pond,G.R., Mawji,I.A., Houghten,R.A., Ostresh,J., Brandwein,J., Minden,M.D., Schuh,A.C., Wells,R.A., Messner,H., Chun,K., Reed,J.C. and Schimmer,A.D.
    Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
    Blood (1-2-2005) 105, 4043-4050. PubMed  Europe PubMed DOI  PMC  EPMC
  34. [YEAR:13-1-2005]Scott,F.L., Denault,J.B., Riedl,S.J., Shin,H., Renatus,M. and Salvesen,G.S.
    XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
    EMBO J (13-1-2005) 24, 645-655. PubMed  Europe PubMed DOI  PMC  EPMC
    35. 2004
  35. [YEAR:24-6-2004]Dohi,T., Okada,K., Xia,F., Wilford,C.E., Samuel,T., Welsh,K., Marusawa,H., Zou,H., Armstrong,R., Matsuzawa,S., Salvesen,G.S., Reed,J.C. and Altieri,D.C.
    An IAP-IAP complex inhibits apoptosis
    J Biol Chem (24-6-2004) 279, 34087-34090. PubMed  Europe PubMed DOI
  36. [YEAR:29-12-2004]Lewis,J., Burstein,E., Reffey,S.B., Bratton,S.B., Roberts,A.B. and Duckett,C.S.
    Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis
    J Biol Chem (29-12-2004) 279, 9023-9029. PubMed  Europe PubMed DOI
  37. Schimmer,A.D., Welsh,K., Pinilla,C., Wang,Z., Krajewska,M., Bonneau,M.J., Pedersen,I.M., Kitada,S., Scott,F.L., Bailly-Maitre,B., Glinsky,G., Scudiero,D., Sausville,E., Salvesen,G., Nefzi,A., Ostresh,J.M., Houghten,R.A. and Reed,J.C.
    Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
    Cancer Cell (2004) 5, 25-35. PubMed  Europe PubMed DOI
  38. [YEAR:12-8-2004]Sun,H., Nikolovska-Coleska,Z., Yang,C.Y., Xu,L., Tomita,Y., Krajewski,K., Roller,P.P. and Wang,S.
    Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site
    J Med Chem (12-8-2004) 47, 4147-4150. PubMed  Europe PubMed DOI
  39. [YEAR:27-8-2004]Wang,Z., Cuddy,M., Samuel,T., Welsh,K., Schimmer,A., Hanaii,F., Houghten,R., Pinilla,C. and Reed,J.C.
    Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors
    J Biol Chem (27-8-2004) 279, 48168-48176. PubMed  Europe PubMed DOI
    40. 2003
  40. Hell,K., Saleh,M., Crescenzo,G.D., O'Connor-McCourt,M.D. and Nicholson,D.W.
    Substrate cleavage by caspases generates protein fragments with Smac/Diablo-like activities
    Cell Death Differ (2003) 10, 1234-1239. PubMed  Europe PubMed DOI
  41. [YEAR:21-7-2003]Kashkar,H., Haefs,C., Shin,H., Hamilton-Dutoit,S.J., Salvesen,G.S., Kronke,M. and Jurgensmeier,J.M.
    XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells
    J Exp Med (21-7-2003) 198, 341-347. PubMed  Europe PubMed DOI  PMC  EPMC
  42. [YEAR:24-11-2003]Potts,P.R., Singh,S., Knezek,M., Thompson,C.B. and Deshmukh,M.
    Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
    J Cell Biol (24-11-2003) 163, 789-799. PubMed  Europe PubMed DOI  PMC  EPMC
  43. [YEAR:1-8-2003]Shin,H., Okada,K., Wilkinson,J.C., Solomon,K.M., Duckett,C.S., Reed,J.C. and Salvesen,G.S.
    Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein
    Biochem J (1-8-2003) 373, 965-971. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Shiozaki,E.N., Chai,J., Rigotti,D.J., Riedl,S.J., Li,P., Srinivasula,S.M., Alnemri,E.S., Fairman,R. and Shi,Y.
    Mechanism of XIAP-mediated inhibition of caspase-9
    Mol Cell (2003) 11, 519-527. PubMed  Europe PubMed DOI  S
  45. [YEAR:22-8-2003]Srinivasula,S.M., Gupta,S., Datta,P., Zhang,Z., Hegde,R., Cheong,N., Fernandes-Alnemri,T. and Alnemri,E.S.
    Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
    J Biol Chem (22-8-2003) 278, 31469-31472. PubMed  Europe PubMed DOI
  46. [YEAR:18-4-2003]Tamm,I., Trepel,M., Cardo-Vila,M., Sun,Y., Welsh,K., Cabezas,E., Swatterthwait,A., Arap,W., Reed,J.C. and Pasqualini,R.
    Peptides targeting caspase inhibitors
    J Biol Chem (18-4-2003) 278, 14401-14405. PubMed  Europe PubMed DOI
  47. [YEAR:9-5-2003]Vaux,D.L. and Silke,J.
    Mammalian mitochondrial IAP binding proteins
    Biochem Biophys Res Commun (9-5-2003) 304, 499-504. PubMed  Europe PubMed DOI
    48. 2002
  48. [YEAR:4-1-2002]Hegde,R., Srinivasula,S.M., Zhang,Z., Wassell,R., Mukattash,R., Cilenti,L., Dubois,G., Lazebnik,Y., Zervos,A.S., Fernandes-Alnemri,T. and Alnemri,E.S.
    Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
    J Biol Chem (4-1-2002) 277, 432-438. PubMed  Europe PubMed DOI
  49. Hofmann,H.S., Simm,A., Hammer,A., Silber,R.E. and Bartling,B.
    Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer
    J Cancer Res Clin Oncol (2002) 128, 554-560. PubMed  Europe PubMed DOI
  50. [YEAR:4-1-2002]Martins,L.M., Iaccarino,I., Tenev,T., Gschmeissner,S., Totty,N.F., Lemoine,N.R., Savopoulos,J., Gray,C.W., Creasy,C.L., Dingwall,C. and Downward,J.
    The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
    J Biol Chem (4-1-2002) 277, 439-444. PubMed  Europe PubMed DOI
  51. [YEAR:20-3-2002]Sauerwald,T.M., Betenbaugh,M.J. and Oyler,G.A.
    Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants
    Biotechnol Bioeng (20-3-2002) 77, 704-716. PubMed  Europe PubMed DOI
  52. [YEAR:1-4-2002]Silke,J., Hawkins,C.J., Ekert,P.G., Chew,J., Day,C.L., Pakusch,M., Verhagen,A.M. and Vaux,D.L.
    The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
    J Cell Biol (1-4-2002) 157, 115-124. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Stennicke,H.R., Ryan,C.A. and Salvesen,G.S.
    Reprieval from execution: the molecular basis of caspase inhibition
    Trends Biochem Sci (2002) 27, 94-101. PubMed  Europe PubMed DOI
  54. Van Loo,G., van Gurp,M., Depuydt,B., Srinivasula,S.M., Rodriguez,I., Alnemri,E.S., Gevaert,K., Vandekerckhove,J., Declercq,W. and Vandenabeele,P.
    The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
    Cell Death Differ (2002) 9, 20-26. PubMed  Europe PubMed DOI
  55. [YEAR:4-1-2002]Verhagen,A.M., Silke,J., Ekert,P.G., Pakusch,M., Kaufmann,H., Connolly,L.M., Day,C.L., Tikoo,A., Burke,R., Wrobel,C., Moritz,R.L., Simpson,R.J. and Vaux,D.L.
    HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    J Biol Chem (4-1-2002) 277, 445-454. PubMed  Europe PubMed DOI
  56. [YEAR:5-4-2002]Vucic,D., Deshayes,K., Ackerly,H., Pisabarro,M.T., Kadkhodayan,S., Fairbrother,W.J. and Dixit,V.M.
    SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)
    J Biol Chem (5-4-2002) 277, 12275-12279. PubMed  Europe PubMed DOI
    57. 2001
  57. [YEAR:1-3-2001]Bratton,S.B., Walker,G., Srinivasula,S.M., Sun,X.M., Butterworth,M., Alnemri,E.S. and Cohen,G.M.
    Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes
    EMBO J (1-3-2001) 20, 998-1009. PubMed  Europe PubMed DOI  PMC  EPMC
  58. [YEAR:9-3-2001]Chai,J.J., Shiozaki,E., Srinivasula,S.M., Wu,Q., Dataa,P., Alnemri,E.S. and Shi,Y.G.
    Structural basis of caspase-7 inhibition by XIAP
    Cell (9-3-2001) 104, 769-780. PubMed  Europe PubMed  S  I
  59. [YEAR:9-3-2001]Huang,Y.H., Park,Y.C., Rich,R.L., Segal,D., Myszka,D.G. and Wu,H.
    Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
    Cell (9-3-2001) 104, 781-790. PubMed  Europe PubMed  S
  60. [YEAR:9-3-2001]Riedl,S.J., Renatus,M., Schwarzenbacher,R., Zhou,Q., Sun,C., Fesik,S.W., Liddington,R.C. and Salvesen,G.S.
    Structural basis for the inhibition of caspase-3 by XIAP
    Cell (9-3-2001) 104, 791-800. PubMed  Europe PubMed  S
  61. [YEAR:1-3-2001]Srinivasula,S.M., Hegde,R., Saleh,A., Datta,P., Shiozaki,E., Chai,J., Lee,R.A., Robbins,P.D., Fernandes-Alnemri,T., Shi,Y. and Alnemri,E.S.
    A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
    Nature (1-3-2001) 410, 112-116. PubMed  Europe PubMed DOI
  62. [YEAR:20-7-2001]Suzuki,Y., Nakabayashi,Y., Nakata,K., Reed,J.C. and Takahashi,R.
    X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and-7 in distinct modes
    J Biol Chem (20-7-2001) 276, 27058-27063. PubMed  Europe PubMed DOI
    63. 2000
  63. [YEAR:13-10-2000]Datta,R., Oki,E., Endo,K., Biedermann,V., Ren,J. and Kufe,D.
    XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage
    J Biol Chem (13-10-2000) 275, 31733-31738. PubMed  Europe PubMed DOI
  64. Deveraux,Q.L., Welsh,K. and Reed,J.C.
    Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors
    Methods Enzymol (2000) 322, 154-161. PubMed  Europe PubMed  V
  65. [YEAR:27-10-2000]Sun,C., Cai,M., Meadows,R.P., Xu,N., Gunasekera,A.H., Herrmann,J., Wu,J.C. and Fesik,S.W.
    NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP
    J Biol Chem (27-10-2000) 275, 33777-33781. PubMed  Europe PubMed DOI  S
    66. 1999
  66. [YEAR:1-10-1999]Deveraux,Q.L., Leo,E., Stennicke,H.R., Welsh,K., Salvesen,G.S. and Reed,J.C.
    Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
    EMBO J (1-10-1999) 18, 5242-5251. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Sun,C., Cai,M., Gunasekera,A.H., Meadows,R.P., Wang,H., Chen,J., Zhang,H., Wu,W., Xu,N., Ng,S.C. and Fesik,S.W.
    NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP
    Nature (1999) 401, 818-822. PubMed  Europe PubMed DOI
    68. 1998
  68. [YEAR:15-4-1998]Deveraux,Q.L., Roy,N., Stennicke,H.R., Van Arsdale,T., Zhou,Q., Srinivasula,S.M., Alnemri,E.S., Salvesen,G.S. and Reed,J.C.
    IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    EMBO J (15-4-1998) 17, 2215-2223. PubMed  Europe PubMed DOI  PMC  EPMC
    69. 1997
  69. [YEAR:17-7-1997]Deveraux,Q.L., Takahashi,R., Salvesen,G.S. and Reed,J.C.
    X-linked IAP is a direct inhibitor of cell-death proteases
    Nature (17-7-1997) 388, 300-304. PubMed  Europe PubMed DOI
  70. [YEAR:15-6-1997]Farahani,R., Fong,W.G., Korneluk,R.G. and MacKenzie,A.E.
    Genomic organization and primary characterization of mIAP-3: the murine homologue of human X-linked IAP
    Genomics (15-6-1997) 42, 514-518. PubMed  Europe PubMed DOI
    71. 1996
  71. [YEAR:1-11-1996]Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
    Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization
    Genomics (1-11-1996) 37, 404-406. PubMed  Europe PubMed DOI
  72. Uren,A.G., Pakusch,M., Hawkins,C.J., Puls,K.L. and Vaux,D.L.
    Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors
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