Merops Switch to
Peptidases

Inhibitor

Family Clan Small-molecule
inhibitor SEARCHES BLAST
MEROPS

Other
information

Literature for inhibitor I25.010: cystatin SN

Summary Gene structure Alignment Sequences Sequence features Distribution Literature

(Topics flags: K Knockout, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Li,D., Wang,Y., Dong,C., Chen,T., Dong,A., Ren,J., Li,W., Shu,G., Yang,J., Shen,W., Qin,L., Hu,L. and Zhou,J.<br>CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1<br>Oncogene (2023) 42, 83-98. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Luo,F.F., Wang,J., Zhang,Z.F., Lin,S.T., Huang,T.J., Liu,B.Q., Fan,M.L., Peng,L.X., Zheng,S.T., Yang,C.F. and Huang,B.J.<br>SPI1-Mediated Upregulation of the CST1 Gene as an Independent Poor Prognostic Factor Accelerates Metastasis in Esophageal Squamous Cell Carcinoma (ESCC) by Interacting with MMP2<br>Front Biosci (Landmark Ed) (2023) 28, 212-212. PubMed  Europe PubMed DOI
  3. Romano,F., Franco,F., Corana,M., Abbadessa,G., Di Scipio,F., Pergolizzi,B., Castrignano,C., Aimetti,M. and Berta,G.N.<br>Cystatin SN (CST1) as a Novel Salivary Biomarker of Periodontitis<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Yan,B., Ren,Y., Liu,C., Shu,L., Wang,C. and Zhang,L.<br>Cystatin SN in type 2 inflammatory airway diseases<br>J Allergy Clin Immunol (2023) 151, 1191-1203. PubMed  Europe PubMed DOI  V
    5. 2022
  5. Nocera,A.L., Mueller,S.K., Workman,A.D., Wu,D., McDonnell,K., Sadow,P.M., Amiji,M.M. and Bleier,B.S.<br>Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis<br>J Allergy Clin Immunol (2022) PubMed  Europe PubMed DOI  K  V
  6. Shen,B., Ding,H., Ye,Y. and Luo,B.<br>Role of the Long Intergenic Non-Protein-Coding RNA 1278/miR-185-5p/Cystatin SN Axis in Laryngeal Cancer Cells<br>J Oncol (2022) 2022, 6406943-6406943. PubMed  Europe PubMed DOI  PMC  EPMC  K
  7. Yang,J., Luo,G., Li,C., Zhao,Z., Ju,S., Li,Q., Chen,Z., Ding,C., Tong,X. and Zhao,J.<br>Cystatin SN promotes epithelial-mesenchymal transition and serves as a prognostic biomarker in lung adenocarcinoma<br>BMC Cancer (2022) 22, 589-589. PubMed  Europe PubMed DOI  PMC  EPMC  K
    8. 2021
  8. Ding,J., Wang,X., Gao,J. and Song,T.<br>Silencing of cystatin SN abrogates cancer progression and stem cell properties in papillary thyroid carcinoma<br>FEBS Open Bio (2021) PubMed  Europe PubMed DOI
    9. 2020
  9. Delimont,N.M. and Nickel,S.<br>Salivary cystatin SN is a factor predicting iron bioavailability after phytic acid rich meals in female participants<br>Int J Food Sci Nutr (2020) , 1-10. PubMed  Europe PubMed DOI
    10. 2019
  10. Delimont,N.M., Katz,B.B., Fiorentino,N.M., Kimmel,K.A., Haub,M.D., Rosenkranz,S.K., Tomich,J.M. and Lindshield,B.L.<br>Salivary cystatin SN binds to phytic acid in vitro and is a predictor of nonheme iron bioavailability with phytic acid supplementation in a proof of concept pilot study<br>Curr Dev Nutr (2019) 3, nzz057-nzz057. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Fukuoka,A., Matsushita,K., Morikawa,T., Adachi,T., Yasuda,K., Kiyonari,H., Fujieda,S. and Yoshimoto,T.<br>Human cystatin SN is an endogenous protease inhibitor that prevents allergic rhinitis<br>J Allergy Clin Immunol (2019) 143, 1153-1162. PubMed  Europe PubMed DOI  U
  12. Liu,Y. and Yao,J.<br>Research progress of cystatin SN in cancer<br>Onco Targets Ther (2019) 12, 3411-3419. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Yan,B., Lou,H., Wang,Y., Li,Y., Meng,Y., Qi,S., Wang,M., Xiao,L., Wang,C. and Zhang,L.<br>Epithelium-derived cystatin SN enhances eosinophil activation and infiltration through IL-5 in patients with chronic rhinosinusitis with nasal polyps<br>J Allergy Clin Immunol (2019) 144, 455-469. PubMed  Europe PubMed DOI
    14. 2017
  14. Oh,S.S., Park,S., Lee,K.W., Madhi,H., Park,S.G., Lee,H.G., Cho,Y.Y., Yoo,J. and Dong Kim,K.<br>Extracellular cystatin SN and cathepsin B prevent cellular senescence by inhibiting abnormal glycogen accumulation<br>Cell Death Dis (2017) 8, e2729-e2729. PubMed  Europe PubMed DOI
    15. 2015
  15. Jiang,J., Liu,H.L., Liu,Z.H., Tan,S.W. and Wu,B.<br>Identification of cystatin SN as a novel biomarker for pancreatic cancer<br>Tumour Biol (2015) 36, 3903-3910. PubMed  Europe PubMed DOI
    16. 2013
  16. Kim,J.T., Lee,S.J., Kang,M.A., Park,J.E., Kim,B.Y., Yoon,D.Y., Yang,Y., Lee,C.H., Yeom,Y.I., Choe,Y.K. and Lee,H.G.<br>Cystatin SN neutralizes the inhibitory effect of cystatin C on cathepsin B activity<br>Cell Death Dis (2013) 4, e974-e974. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2009
  17. Choi,E.H., Kim,J.T., Kim,J.H., Kim,S.Y., Song,E.Y., Kim,J.W., Kim,S.Y., Yeom,Y.I., Kim,I.H. and Lee,H.G.<br>Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer<br>Clin Chim Acta (2009) 406, 45-51. PubMed  Europe PubMed DOI
    18. 2002
  18. Dickinson,D.P., Thiesse,M. and Hicks,M.J.<br>Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland<br>DNA Cell Biol (2002) 21, 47-65. PubMed  Europe PubMed DOI
    19. 2000
  19. [YEAR:1-8-2000]Tseng,C.C., Tseng,C.P., Levine,M.J. and Bobek,L.A.<br>Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system<br>Arch Biochem Biophys (1-8-2000) 380, 133-140. PubMed  Europe PubMed DOI
    20. 1999
  20. Hiltke,T.R., Lee,T.C. and Bobek,L.A.<br>Structure/function analysis of human cystatin SN and comparison of the cysteine proteinase inhibitory profiles of human cystatins C and SN<br>J Dent Res (1999) 78, 1401-1409. PubMed  Europe PubMed
    21. 1997
  21. Bell,J.E., Cunningham,E., Belt,C., Featherstone,J.D. and Bell,J.<br>Examination of the potential structure of human salivary cystatins based on computer modelling<br>Arch Oral Biol (1997) 42, 761-772. PubMed  Europe PubMed DOI
    22. 1996
  22. Ramasubbu,N., Weaver,T., Tseng,C.C., Bobek,L.A. and Levine,M.J.<br>Preliminary X-ray crystallographic analysis of human salivary cystatin<br>Acta Crystallogr D Biol Crystallogr (1996) 52, 869-870. PubMed  Europe PubMed DOI
    23. 1993
  23. Ramasubbu,N., Gonzalez,M., Bobek,L.A. and Levine,M.J.<br>Unfolding transitions of cystatins: differences between chicken egg-white and salivary cystatin sn<br>Protein Eng Des Sel (1993) 6, 23- DOI
    24. 1991
  24. Isemura,S., Saitoh,E., Sanada,K. and Minakata,K.<br>Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S<br>J Biochem (1991) 110, 648-654. PubMed  Europe PubMed
    25. 1987
  25. Saitoh,E., Kim,H.S., Smithies,O. and Maeda,N.<br>Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family<br>Gene (1987) 61, 329-338. PubMed  Europe PubMed
    26. 1986
  26. Isemura,S., Saitoh,E. and Sanada,K.<br>Characterization of a new cysteine proteinase inhibitor of human saliva, cystatin SN, which is immunologically related to cystatin S<br>FEBS Lett (1986) 198, 145-149. PubMed  Europe PubMed
    27. 1984
  27. Minakata,K. and Asano,M.<br>New protein inhibitors of cysteine proteinases in human saliva and salivary glands<br>Hoppe Seylers Z Physiol Chem (1984) 365, 399-403. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use