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Literature for inhibitor I13.001: eglin c

Summary Alignment Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2009
  1. Deng,N.J. and Cieplak,P.
    Insights into affinity and specificity in the complexes of alpha-lytic protease and its inhibitor proteins: binding free energy from molecular dynamics simulation
    Phys Chem Chem Phys11, 4968-4981. PubMed  Europe PubMed DOI
    2. 2008
  2. Materese,C.K., Goldmon,C.C. and Papoian,G.A.
    Hierarchical organization of eglin c native state dynamics is shaped by competing direct and water-mediated interactions
    Proc Natl Acad Sci U S A105, 10659-10664. PubMed  Europe PubMed DOI
    3. 2006
  3. [YEAR:20-3-2006]Desilets,A., Longpre,J.M., Beaulieu,M.E. and Leduc,R.
    Inhibition of human matriptase by eglin c variants
    FEBS Lett580, 2227-2232. PubMed  Europe PubMed DOI
  4. [YEAR:9-12-2006]Fetrow,J.S., Knutson,S.T. and Edgell,M.H.
    Mutations in alpha-helical solvent-exposed sites of eglin c have long-range effects: evidence from molecular dynamics simulations
    Proteins63, 356-372. PubMed  Europe PubMed DOI
  5. [YEAR:26-9-2006]Qasim,M.A., Van Etten,R.L., Yeh,T., Saunders,C., Ganz,P.J., Qasim,S., Wang,L. and Laskowski,M., Jr.
    Despite having a common P1 Leu, eglin C inhibits alpha-lytic proteinase a million-fold more strongly than does turkey ovomucoid third domain
    Biochemistry45, 11342-11348. PubMed  Europe PubMed DOI
    6. 2004
  6. Cai,X.H., Zhang,Q. and Ding,D.F.
    Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations
    Acta Pharmacol Sin25, 1712-1818. PubMed  Europe PubMed
  7. [YEAR:5-10-2004]Clarkson,M.W. and Lee,A.L.
    Long-range dynamic effects of point mutations propagate through side chains in the serine protease inhibitor eglin c
    Biochemistry43, 12448-12458. PubMed  Europe PubMed DOI
  8. [YEAR:2-1-2004]Liu,Z.X., Fei,H. and Chi,C.W.
    Two engineered eglin c mutants potently and selectively inhibiting kexin or furin
    FEBS Lett556, 116-120. PubMed  Europe PubMed DOI
    9. 2003
  9. [YEAR:8-7-2003]Komiyama,T., VanderLugt,B., Fugere,M., Day,R., Kaufman,R.J. and Fuller,R.S.
    Optimization of protease-inhibitor interactions by randomizing adventitious contacts
    Proc Natl Acad Sci U S A100, 8205-8210. PubMed  Europe PubMed DOI
    10. 2000
  10. [YEAR:12-12-2000]Komiyama,T. and Fuller,R.S.
    Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin
    Biochemistry39, 15156-15165. PubMed  Europe PubMed DOI
    11. 1998
  11. [YEAR:18-8-1998]Martin,F., Dimasi,N., Volpari,C., Perrera,C., Di Marco,S., Brunetti,M., Steinkuhler,C., De Francesco,R. and Sollazzo,M.
    Design of selective eglin inhibitors of HCV NS3 proteinase
    Biochemistry37, 11459-11468. PubMed  Europe PubMed DOI
    12. 1996
  12. Dauter,Z., Betzel,C., Genov,N. and Wilson,K.S.
    The complex between mesentericopeptidase and eglin-C
    Adv Exp Med Biol379, 1-4. PubMed  Europe PubMed
  13. Hipler,K., Priestle,J.P., Rahuel,J. and Grutter,M.G.
    Active site binding loop stabilization in the subtilisin inhibitor eglin c: structural and functional studies on specifically designed mutants in complex with subtilisin and the uncomplexed inhibitor
    Adv Exp Med Biol379, 43-47. PubMed  Europe PubMed
    14. 1995
  14. Ascenzi,P., Amiconi,G., Bode,W., Bolognesi,M., Coletta,M. and Menegatti,E.
    Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects
    Mol Aspects Med16, 215-313. PubMed  Europe PubMed DOI  V
    15. 1993
  15. [YEAR:15-2-1993]Betzel,C., Dauter,Z., Genov,N., Lamzin,V., Navaza,J., Schnebli,H.P., Visanji,M. and Wilson,K.S.
    Structure of the proteinase inhibitor eglin c with hydrolysed reactive centre at 2.0 A resolution
    FEBS Lett317, 185-188. PubMed  Europe PubMed DOI  S
  16. [YEAR:5-12-1993]Krystek,S., Stouch,T. and Novotny,J.
    Affinity and specificity of serine endopeptidase-protein inhibitor interactions. Empirical free energy calculations based on X-ray crystallographic structures
    J Mol Biol234, 661-679. PubMed  Europe PubMed DOI
    17. 1992
  17. [YEAR:5-5-1992]Frigerio,F., Coda,A., Pugliese,L., Lionetti,C., Menegatti,E., Amiconi,G., Schnebli,H.P., Ascenzi,P. and Bolognesi,M.
    Crystal and molecular structure of the bovine alpha-chymotrypsin-eglin c complex at 2.0 A resolution
    J Mol Biol225, 107-123. PubMed  Europe PubMed DOI  S
  18. Gros,P., Teplyakov,A.V. and Hol,W.G.
    Effects of eglin-c binding to thermitase: three-dimensional structure comparison of native thermitase and thermitase eglin-c complexes
    Proteins12, 63-74. PubMed  Europe PubMed DOI
  19. Heinz,D.W., Hyberts,S.G., Peng,J.W., Priestle,J.P., Wagner,G. and Grutter,M.G.
    Changing the inhibitory specificity and function of the proteinase inhibitor eglin c by site-directed mutagenesis: Functional and structural investigation
    Biochemistry31, 8755-8766. PubMed  Europe PubMed DOI  S
  20. Hipler,K., Priestle,J.P., Rahuel,J. and Grutter,M.G.
    X-ray crystal structure of the serine proteinase inhibitor eglin c at 1.95 A resolution
    FEBS Lett309, 139-145. PubMed  Europe PubMed DOI  S
  21. Hyberts,S.G., Goldberg,M.S., Havel,T.F. and Wagner,G.
    The solution structure of eglin c based on measurements of many NOEs and coupling constants and its comparison with X-ray structures
    Protein Sci1, 736-751. PubMed  Europe PubMed DOI  S
  22. [YEAR:15-9-1992]Peng,J.W. and Wagner,G.
    Mapping of the spectral densities of N-H bond motions in eglin c using heteronuclear relaxation experiments
    Biochemistry31, 8571-8586. PubMed  Europe PubMed
  23. Roters,F.J. and Zebe,E.
    Protease inhibitors in the alimentary tract of the medicinal leech Hirudo medicinalis: in vivo and in vitro studies
    J Comp Physiol B162, 85-92. PubMed  Europe PubMed DOI
    24. 1991
  24. Ascenzi,P., Aducci,P., Amiconi,G., Ballio,A., Guaragna,A., Menegatti,E., Schnebli,H.P. and Bolognesi,M.
    Binding of the recombinant proteinase inhibitor eglin c from leech Hirudo medicinalis to serine (pro)enzymes: a comparative thermodynamic study
    J Mol Recognit4, 113-119. PubMed  Europe PubMed DOI
  25. [YEAR:1-10-1991]Dauter,Z., Betzel,C., Genov,N., Pipon,N. and Wilson,K.S.
    Complex between the subtilisin from a mesophilic bacterium and the leech inhibitor eglin-C
    Acta Crystallogr B47, 707-730. PubMed  Europe PubMed DOI  S
  26. Heinz,D.W., Priestle,J.P., Rahuel,J., Wilson,K.S. and Grutter,M.G.
    Refined crystal structures of subtilisin novo in complex with wild-type and two mutant eglins. Comparison with other serine proteinase inhibitor complexes
    J Mol Biol217, 353-371. PubMed  Europe PubMed DOI  S
  27. Okada,Y. and Tsuboi,S.
    Amino acids and peptides. Part 31. Total synthesis of eglin c. Part 1. Synthesis of a triacontapeptide corresponding to the C-terminal sequence 41-70 of eglin c and related peptides and studies on the relationship between the structure and inhibitory activity against human leukocyte elastase, cathepsin G and alpha-chymotrypsin
    Chem Soc J [Perkin 1]1, 3315-3319.
    28. 1990
  28. Bolognesi,M., Pugliese,L., Gatti,G., Frigerio,F., Coda,A., Antolini,L., Schnebli,H.P., Menegatti,E., Amiconi,G. and Ascenzi,P.
    X-ray crystal structure of the bovine alpha-chymotrypsin/eglin c complex at 2.6 A resolution
    J Mol Recognit3, 163-168. PubMed  Europe PubMed DOI  S
  29. Hyberts,S.G. and Wagner,G.
    Sequence-specific 1H NMR assignments and secondary structure of eglin c
    Biochemistry29, 1465-1474. PubMed  Europe PubMed  S
  30. Okada,Y., Tsuboi,S., Tsuda,Y., Nagamatsu,Y. and Yamamoto,J.
    Synthesis of a trihexacontapeptide corresponding to the sequence 8-70 of eglin c and studies on the relationship between the structure and the inhibitory activity against human leukocyte elastase, cathepsin G and alpha-chymotrypsin
    FEBS Lett272, 113-116. PubMed  Europe PubMed DOI
    31. 1989
  31. Gros,P., Fujinaga,M., Dijkstra,B.W., Kalk,K.H. and Hol,W.G.
    Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c
    Acta Crystallogr B45, 488-499. PubMed  Europe PubMed DOI  S
  32. Heinz,D.W., Liersch,M. and Grutter,M.G.
    Crystallization of human leukocyte elastase with its inhibitor Pro44-eglin c
    J Mol Biol207, 641-642. PubMed  Europe PubMed  S
    33. 1988
  33. [YEAR:15-8-1988]Dauter,Z., Betzel,C., Hohne,W.E., Ingelman,M. and Wilson,K.S.
    Crystal structure of a complex between thermitase from Thermoactinomyces vulgaris and the leech inhibitor eglin
    FEBS Lett236, 171-178. PubMed  Europe PubMed
  34. McPhalen,C.A. and James,M.N.
    Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo
    Biochemistry27, 6582-6598. PubMed  Europe PubMed  S
    35. 1987
  35. Bode,W., Papamokos,E. and Musil,D.
    The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry
    Eur J Biochem166, 673-692. PubMed  Europe PubMed  S
  36. Braun,N.J., Bodmer,J.L., Virca,G.D., Metz-Virca,G., Maschler,R., Bieth,J.G. and Schnebli,H.P.
    Kinetic studies on the interaction of eglin c with human leukocyte elastase and cathepsin G
    Biol Chem Hoppe Seyler368, 299-308. PubMed  Europe PubMed
    37. 1986
  37. Bode,W., Papamokos,E., Musil,D., Seemueller,U. and Fritz,H.
    Refined 1.2 A crystal structure of the complex formed between subtilisin Carlsberg and the inhibitor eglin c. Molecular structure of eglin and its detailed interaction with subtilisin
    EMBO J5, 813-818. PubMed  Europe PubMed  S
  38. Seemuller,U., Dodt,J., Fink,E. and Fritz,H.
    Proteinase inhibitors of the leech Hirudo medicinalis (hirudins, bdellins, eglins)
    337-359.
    39. 1985
  39. Chang,J.Y., Knecht,R., Maschler,R. and Seemuller,U.
    Elastase-cathepsin G inhibitors eglin b and eglin c differ by a single Tyr - His substitution. A micro-method for the identification of amino-acid substitution
    Biol Chem Hoppe Seyler366, 281-286. PubMed  Europe PubMed
  40. Kiyohara,T. and Iwasaki,T.
    Purification and some properties of trypsin inhibitors from buckwheat seeds
    Agric Biol Chem49, 581-588. DOI
  41. [YEAR:19-8-1985]McPhalen,C.A., Schnebli,H.P. and James,M.N.
    Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg
    FEBS Lett188, 55-58. PubMed  Europe PubMed  S
  42. Schnebli,H.P., Seemuller,U., Fritz,H., Maschler,R., Liersch,M., Virca,G.D., Bodmer,J.L., Snider,G.L., Lucey,E.C. and Stone,P.G.
    Eglin c, a pharmacologically active elastase inhibitor
    Eur J Respir Dis Suppl139, 66-70. PubMed  Europe PubMed
    43. 1984
  43. [YEAR:15-3-1984]Baici,A. and Seemuller,U.
    Kinetics of the inhibition of human leucocyte elastase by eglin from the leech Hirudo medicinalis
    Biochem J218, 829-833. PubMed  Europe PubMed
  44. [YEAR:24-8-1984]Rink,H., Liersch,M., Sieber,P. and Meyer,F.
    A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli
    Nucleic Acids Res12, 6369-6387. PubMed  Europe PubMed  E
    45. 1983
  45. [YEAR:1-4-1983]Knecht,R., Seemuller,U., Liersch,M., Fritz,H., Braun,D.G. and Chang,J.Y.
    Sequence determination of eglin C using combined microtechniques of amino acid analysis, peptide isolation, and automatic Edman degradation
    Anal Biochem130, 65-71. PubMed  Europe PubMed
    46. 1981
  46. Seemuller,U., Fritz,H. and Eulitz,M.
    [60] Eglin: elastase-cathepsin G inhibitor from leeches
    Methods Enzymol80, 804-816. DOI
    47. 1980
  47. Seemuller,U., Eulitz,M., Fritz,H. and Strobl,A.
    Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis
    Hoppe Seylers Z Physiol Chem361, 1841-1846. PubMed  Europe PubMed
    48. 1977
  48. Seemuller,U., Meier,M., Ohlsson,K., Muller,H.P. and Fritz,H.
    Isolation and characterisation of a low molecular weight inhibitor (of chymotrypsin and human granulocytic elastase and cathepsin G) from leeches
    Hoppe Seylers Z Physiol Chem358, 1105-1107. PubMed  Europe PubMed

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