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Literature for inhibitor I04.002: alpha-1-antichymotrypsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, M Mutation, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zhang,G., Sun,X., Zhang,D., Zhang,X. and Yu,K.
    SerpinA3 Promotes Myocardial Infarction in Rat and Cell-based Models
    Mol Biotechnol (2025) 67, 92-103. PubMed  Europe PubMed DOI
    2. 2024
  2. Barter,M.J., Turner,D.A., Rice,S.J., Hines,M., Lin,H., Falconer,A.M.D., McDonnell,E., Soul,J., Del Carmen Arques,M., Europe-Finner,G.N., Rowan,A.D., Young,D.A. and Wilkinson,D.J.
    SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesis
    Matrix Biol (2024) 133, 33-42. PubMed  Europe PubMed DOI  K
  3. Kontoh-Twumasi,R., Budkin,S., Edupuganti,N., Vashishtha,A. and Sharma,S.
    Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies
    Invest Ophthalmol Vis Sci (2024) 65, 16-16. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2022
  4. Fatima,S., Gupta,S., Khan,A.B., Rehman,S.U. and Jairajpuri,M.A.
    Identification and validation of two alternatively spliced novel isoforms of human alpha-1-antichymotrypsin
    Biochem Biophys Res Commun (2022) 628, 25-31. PubMed  Europe PubMed DOI
  5. Jin,Y., Wang,W., Wang,Q., Zhang,Y., Zahid,K.R., Raza,U. and Gong,Y.
    Alpha-1-antichymotrypsin as a novel biomarker for diagnosis, prognosis, and therapy prediction in human diseases
    Cancer Cell Int (2022) 22, 156-156. PubMed  Europe PubMed DOI  PMC  EPMC  V
    6. 2021
  6. Li,B., Lei,Z., Wu,Y., Li,B., Zhai,M., Zhong,Y., Ju,P., Kou,W., Shi,Y., Zhang,X. and Peng,W.
    The Association and Pathogenesis of SERPINA3 in Coronary Artery Disease
    Front Cardiovasc Med (2021) 8, 756889-756889. PubMed  Europe PubMed DOI  PMC  EPMC  K
    7. 2020
  7. Koivuluoma,S., Tervasmaki,A., Kauppila,S., Winqvist,R., Kumpula,T., Kuismin,O., Moilanen,J. and Pylkas,K.
    Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer
    Eur J Cancer (2020) 143, 46-51. PubMed  Europe PubMed DOI
  8. Sanchez-Navarro,A., Gonzalez-Soria,I., Caldino-Bohn,R. and Bobadilla,N.A.
    Integrative view of serpins in health and disease: the contribution of serpinA3
    Am J Physiol Cell Physiol (2020) PubMed  Europe PubMed DOI  V
    9. 2016
  9. Madsen,J.B., Andersen,L.M., Dupont,D.M., Trelle,M.B., Johansen,J.S., Jensen,J.K., Jorgensen,T.J. and Andreasen,P.A.
    An RNA aptamer inhibits a mutation-induced inactivating misfolding of a serpin
    Cell Chem Biol (2016) 23, 700-708. PubMed  Europe PubMed DOI  I
    10. 2015
  10. Marcet-Palacios,M., Ewen,C., Pittman,E., Duggan,B., Carmine-Simmen,K., Fahlman,R.P. and Bleackley,R.C.
    Design and characterization of a novel human granzyme B inhibitor
    Protein Eng Des Sel (2015) 28, 9-17. PubMed  Europe PubMed DOI
    11. 2013
  11. Santamaria,M., Pardo-Saganta,A., Alvarez-Asiain,L., Di Scala,M., Qian,C., Prieto,J. and Avila,M.A.
    Nuclear alpha1-antichymotrypsin promotes chromatin condensation and inhibits proliferation of human hepatocellular carcinoma cells
    Gastroenterology (2013) 144, 818-828. PubMed  Europe PubMed DOI
  12. Zhu,L., Jaamaa,S., Af Hallstrom,T.M., Laiho,M., Sankila,A., Nordling,S., Stenman,U.H. and Koistinen,H.
    PSA forms complexes with alpha1-antichymotrypsin in prostate
    Prostate (2013) 73, 219-226. PubMed  Europe PubMed DOI
    13. 2011
  13. Hoffmann,D.C., Textoris,C., Oehme,F., Klaassen,T., Goppelt,A., Romer,A., Fugmann,B., Davidson,J.M., Werner,S., Krieg,T. and Eming,S.A.
    Pivotal role for alpha1-antichymotrypsin in skin repair
    J Biol Chem (2011) 286, 28889-28901. PubMed  Europe PubMed DOI
  14. Wladyka,B., Kozik,A.J., Bukowski,M., Rojowska,A., Kantyka,T., Dubin,G. and Dubin,A.
    alpha1-Antichymotrypsin inactivates staphylococcal cysteine protease in cross-class inhibition
    Biochimie (2011) 93, 948-953. PubMed  Europe PubMed DOI
    15. 2010
  15. Pearce,M.C., Powers,G.A., Feil,S.C., Hansen,G., Parker,M.W. and Bottomley,S.P.
    Identification and characterization of a misfolded monomeric serpin formed at physiological temperature
    J Mol Biol (2010) 403, 459-467. PubMed  Europe PubMed DOI
    16. 2009
  16. Zamolodchikova,T.S., Popykina,N.A., Gladysheva,I.P. and Larionova,N.I.
    Effect of reactive center loop structure of antichymotrypsin on inhibition of duodenase activity
    Biochemistry (Mosc) (2009) 74, 824-833. PubMed  Europe PubMed DOI
    17. 2008
  17. Manolov,T., Forsgren,A. and Riesbeck,K.
    Purification of alpha1-antichymotrypsin from human plasma with recombinant M. catarrhalis ubiquitous surface protein A1
    J Immunol Methods (2008) 333, 180-185. PubMed  Europe PubMed DOI
  18. Pelissier,P., Delourme,D., Germot,A., Blanchet,X., Becila,S., Maftah,A., Leveziel,H., Ouali,A. and Bremaud,L.
    An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region
    BMC Genomics (2008) 9, 151-151. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2007
  19. Baker,C., Belbin,O., Kalsheker,N. and Morgan,K.
    SERPINA3 (aka alpha-1-antichymotrypsin)
    Front Biosci (2007) 12, 2821-2835. PubMed  Europe PubMed DOI  V
  20. Chelbi,S.T., Mondon,F., Jammes,H., Buffat,C., Mignot,T.M., Tost,J., Busato,F., Gut,I., Rebourcet,R., Laissue,P., Tsatsaris,V., Goffinet,F., Rigourd,V., Carbonne,B., Ferre,F. and Vaiman,D.
    Expressional and epigenetic alterations of placental serine protease inhibitors: SERPINA3 is a potential marker of preeclampsia
    Hypertension (2007) 49, 76-83. PubMed  Europe PubMed DOI
  21. Krischek,B., Akagawa,H., Tajima,A., Narita,A., Kasuya,H., Hori,T. and Inoue,I.
    The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population
    Cerebrovasc Dis (2007) 23, 46-49. PubMed  Europe PubMed DOI  M
    22. 2006
  22. Felber,L.M., Kundig,C., Borgono,C.A., Chagas,J.R., Tasinato,A., Jichlinski,P., Gygi,C.M., Leisinger,H.J., Diamandis,E.P., Deperthes,D. and Cloutier,S.M.
    Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14
    FEBS J (2006) 273, 2505-2514. PubMed  Europe PubMed DOI
    23. 2005
  23. Slowik,A., Borratynska,A., Turaj,W., Pera,J., Dziedzic,T., Figlewicz,D.A., Betlej,M., Krzyszkowski,T., Czepko,R. and Szczudlik,A.
    Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage
    Stroke (2005) 36, 737-740. PubMed  Europe PubMed DOI  M
    24. 2004
  24. Cloutier,S.M., Kundig,C., Felber,L.M., Fattah,O.M., Chagas,J.R., Gygi,C.M., Jichlinski,P., Leisinger,H.J. and Deperthes,D.
    Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates
    Eur J Biochem (2004) 271, 607-613. PubMed  Europe PubMed DOI
  25. [YEAR:12-11-2004]Pearce,M.C., Cabrita,L.D., Rubin,H., Gore,M.G. and Bottomley,S.P.
    Identification of residual structure within denatured antichymotrypsin: implications for serpin folding and misfolding
    Biochem Biophys Res Commun (12-11-2004) 324, 729-735. PubMed  Europe PubMed DOI
    26. 2003
  26. [YEAR:4-3-2003]Crowther,D.C., Serpell,L.C., Dafforn,T.R., Gooptu,B. and Lomas,D.A.
    Nucleation of alpha1-antichymotrypsin polymerization
    Biochemistry (4-3-2003) 42, 2355-2363. PubMed  Europe PubMed DOI
  27. Forsyth,S., Horvath,A. and Coughlin,P.
    A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins
    Genomics (2003) 81, 336-345. PubMed  Europe PubMed DOI
  28. Hutchinson,S., Luo,L.Y., Yousef,G.M., Soosaipillai,A. and Diamandis,E.P.
    Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin
    Clin Chem (2003) 49, 746-751. PubMed  Europe PubMed DOI
  29. [YEAR:1-4-2003]Morris,E.C., Dafforn,T.R., Forsyth,S.L., Missen,M.A., Horvath,A.J., Hampson,L., Hampson,I.N., Currie,G., Carrell,R.W. and Coughlin,P.B.
    Murine serpin 2A is a redox-sensitive intracellular protein
    Biochem J (1-4-2003) 371, 165-173. PubMed  Europe PubMed DOI  PMC  EPMC
    30. 2002
  30. Chowanadisai,W. and Lonnerdal,B.
    Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability
    Am J Clin Nutr (2002) 76, 828-833. PubMed  Europe PubMed
  31. [YEAR:16-8-2002]Plotnick,M.I., Rubin,H. and Schechter,N.M.
    The effects of reactive site location on the inhibitory properties of the serpin alpha(1)-antichymotrypsin
    J Biol Chem (16-8-2002) 277, 29927-29935. PubMed  Europe PubMed DOI
  32. Wang,X., DeKosky,S.T., Luedecking-Zimmer,E., Ganguli,M. and Kamboh,M.I.
    Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease
    Hum Genet (2002) 110, 356-365. PubMed  Europe PubMed DOI  M
    33. 2000
  33. Gooptu,B., Hazes,B., Chang,W.S., Dafforn,T.R., Carrell,R.W., Read,R.J. and Lomas,D.A.
    Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease
    Proc Natl Acad Sci U S A (2000) 97, 67-72. PubMed  Europe PubMed  PMC  EPMC  S
  34. Pimenta,D.C., Chen,V.C., Chao,J., Juliano,M.A. and Juliano,L.
    Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D
    J Protein Chem (2000) 19, 411-418. PubMed  Europe PubMed DOI
    35. 1998
  35. Lukacs,C.M., Rubin,H. and Christianson,D.W.
    Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction
    Biochemistry (1998) 37, 3297-3304. PubMed  Europe PubMed DOI  S
    36. 1997
  36. [YEAR:1-1-1997]Hampson,I.N., Hampson,L., Pinkoski,M., Cross,M., Heyworth,C.M., Bleackley,R.C., Atkinson,E. and Dexter,T.M.
    Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells
    Blood (1-1-1997) 89, 108-118. PubMed  Europe PubMed
    37. 1996
  37. Villoutreix,B.O., Lilja,H., Pettersson,K., Lovgren,T. and Teleman,O.
    Structural investigation of the alpha-1-antichymotrypsin:prostate-specific antigen complex by comparative model building
    Protein Sci (1996) 5, 836-851. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 1991
  38. Baumann,U., Huber,R., Bode,W., Grosse,D., Lesjak,M. and Laurell,C.B.
    Crystal structure of cleaved human alpha1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins
    J Mol Biol (1991) 218, 595-606. PubMed  Europe PubMed  S
  39. Inglis,J.D. and Hill,R.E.
    The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain
    EMBO J (1991) 10, 255-261. PubMed  Europe PubMed  PMC  EPMC
  40. Mast,A.E., Enghild,J.J., Nagase,H., Suzuki,K., Pizzo,S.V. and Salvesen,G.
    Kinetics and physiologic relevance of the inactivation of alpha1- proteinase inhibitor, alpha1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
    J Biol Chem (1991) 266, 15810-15816. PubMed  Europe PubMed
  41. [YEAR:15-11-1991]Potempa,J., Fedak,D., Dubin,A., Mast,A. and Travis,J.
    Proteolytic inactivation of alpha-1-anti-chymotrypsin. Sites of cleavage and generation of chemotactic activity
    J Biol Chem (15-11-1991) 266, 21482-21487. PubMed  Europe PubMed
    42. 1990
  42. Christensson,A., Laurell,C.B. and Lilja,H.
    Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors
    Eur J Biochem (1990) 194, 755-763. PubMed  Europe PubMed
    43. 1983
  43. [YEAR:25-10-1983]Chandra,T., Stackhouse,R., Kidd,V.J., Robson,K.J. and Woo,S.L.
    Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III
    Biochemistry (25-10-1983) 22, 5055-5061. PubMed  Europe PubMed
  44. [YEAR:16-3-1983]Morii,M. and Travis,J.
    Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma
    Biochem Biophys Res Commun (16-3-1983) 111, 438-443. PubMed  Europe PubMed
  45. [YEAR:10-11-1983]Morii,M. and Travis,J.
    Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin
    J Biol Chem (10-11-1983) 258, 12749-12752. PubMed  Europe PubMed
    46. 1978
  46. [YEAR:26-12-1978]Travis,J., Garner,D. and Bowen,J.
    Human alpha-1-antichymotrypsin: purification and properties
    Biochemistry (26-12-1978) 17, 5647-5651. PubMed  Europe PubMed

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