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Literature for inhibitor I01.011: SPINK1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature

(Topics flags: S Structure, M Mutation, K Knockout, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Wang,Q.W., Zou,W.B., Masson,E., Ferec,C., Liao,Z. and Chen,J.M.
    Genetics and clinical implications of SPINK1 in the pancreatitis continuum and pancreatic cancer
    Hum Genomics19, 32-32. PubMed  Europe PubMed DOI  V
    2. 2024
  2. Demcsak,A. and Sahin-Toth,M.
    Heterozygous Spink1 deficiency promotes trypsin-dependent chronic pancreatitis in mice
    Cell Mol Gastroenterol Hepatol18, 101361-101361. PubMed  Europe PubMed DOI
  3. Lu,F., Ott,C., Bista,P. and Lu,X.
    Three-Dimensional Structure of Novel Liver Cancer Biomarker Liver Cancer-Specific Serine Protease Inhibitor Kazal (LC-SPIK) and Its Performance in Clinical Diagnosis of Hepatocellular Carcinoma (HCC)
    Diagnostics (Basel)14, PubMed  Europe PubMed DOI
    4. 2023
  4. Nagel,F., Susemihl,A., Eulberg,T. and Delcea,M.
    Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties
    Biochemistry62, 535-542. PubMed  Europe PubMed DOI
    5. 2022
  5. Chen,Y.T., Tseng,T.T., Tsai,H.P., Kuo,S.H., Huang,M.Y., Wang,J.Y. and Chai,C.Y.
    Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine
    Hum Cell35, 1912-1927. PubMed  Europe PubMed DOI
  6. Nicolli,A.R., Alonso,C.A.I., Otamendi,C., Cerletti,M., Poetsch,A., Sharma,V., Zalazar,L., Perez-Martinez,S. and Cesari,A.
    How, where and when is SPINK3 bound and removed from mouse sperm?
    Reproduction163, 251-266. PubMed  Europe PubMed DOI
    7. 2021
  7. Akhmedov,V.A. and Gaus,O.V.
    [Inflammatory diseases of the pancreas: what new do we know about the mechanisms of their development in the 21st century?]
    Ter Arkh93, 66-70. PubMed  Europe PubMed DOI
  8. Lin,T.C.
    Functional Roles of SPINK1 in Cancers
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  9. Szabo,A., Toldi,V., Gazda,L.D., Demcsak,A., Tozser,J. and Sahin-Toth,M.
    Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis
    J Biol Chem100343-100343. PubMed  Europe PubMed DOI
    10. 2020
  10. Felicelli,C. and Pezhouh,M.K.
    Histopathology of SPINK-1 Hereditary Pancreatitis
    Int J Surg Pathol1066896920980086-1066896920980086. PubMed  Europe PubMed DOI
  11. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.
    Clinical interpretation of SPINK1 and CTRC variants in pancreatitis
    Pancreatology20, 1354-1367. PubMed  Europe PubMed DOI  V
  12. Ni Chonchubhair,H.M., Duggan,S.N., Egan,S.M., Kenyon,M., O'Toole,D., McManus,R. and Conlon,K.C.
    A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland
    HPB (Oxford) PubMed  Europe PubMed DOI
  13. Tornberg,S.V., Nisen,H., Jarvinen,P., Jarvinen,R., Kilpelainen,T.P., Taari,K., Stenman,U.H. and Visapaa,H.
    Serum tumour associated trypsin inhibitor, as a biomarker for survival in renal cell carcinoma
    Scand J Urol1-7. PubMed  Europe PubMed DOI
  14. Wang,Z.C., Li,Y., Wang,K.L., Wang,L., You,B.S., Zhao,D.F., Liu,Z.Q., Fang,R.Z., Wang,J.Q., Zhang,W., Zhang,J.M. and Xu,W.H.
    miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling
    Aging (Albany NY)12, 14418-14433. PubMed  Europe PubMed DOI  K
    15. 2019
  15. Buchholz,I., Nagel,F., Klein,A., Wagh,P.R., Mahajan,U.M., Greinacher,A., Lerch,M.M., Mayerle,J. and Delcea,M.
    The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant
    Biochim Biophys Acta Proteins Proteom140281-140281. PubMed  Europe PubMed DOI  M
    16. 2018
  16. Hama,T., Nakanishi,N., Suzuki,M., Shima,Y. and Suzuki,H.
    Serine protease inhibitor Kazal type I (SPINK1) mutation: a risk factor for early-onset chronic pancreatitis?
    J Pediatr Gastroenterol Nutr67, e40-e40. PubMed  Europe PubMed DOI  M
    17. 2017
  17. Patel,J., Madan,A., Gammon,A., Sossenheimer,M. and Samadder,N.J.
    Rare hereditary cause of chronic pancreatitis in a young male: SPINK1 mutation
    Pan Afr Med J28, 110-110. PubMed  Europe PubMed DOI  M
    18. 2016
  18. da Costa,M.Z., Pires,J.G., Nasser,P.D., Ferreira,C.D., Teixeira,A.C., Paranagua-Vezozzo,D.C., Guarita,D.R., Carrilho,F.J. and Ono,S.K.
    Frequency of tabagism and N34S and P55S mutations of serine peptidase inhibitor, Kazal type 1 (SPINK1) and R254W mutation of chymotrypsin C (CTRC) in patients with chronic pancreatitis and controls
    Pancreas45, 1330-1335. PubMed  Europe PubMed DOI  M
  19. Sakata,K., Araki,K., Nakano,H., Nishina,T., Komazawa-Sakon,S., Murai,S., Lee,G.E., Hashimoto,D., Suzuki,C., Uchiyama,Y., Notohara,K., Gukovskaya,A.S., Gukovsky,I., Yamamura,K.I., Baba,H. and Ohmuraya,M.
    Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
    Sci Rep6, 37200-37200. PubMed  Europe PubMed DOI
  20. Zhang,J., Wang,D., Hu,N., Wang,Q., Yu,S. and Wang,J.
    The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line
    Tumour Biol37, 5847-5855. PubMed  Europe PubMed DOI  E
    21. 2015
  21. Kumaresan,V., Harikrishnan,R. and Arockiaraj,J.
    A potential Kazal-type serine protease inhibitor involves in kinetics of protease inhibition and bacteriostatic activity
    Fish Shellfish Immunol42, 430-438. PubMed  Europe PubMed DOI
  22. Sun,C., Liu,M.Y., Liu,X.G., Hu,L.H., Xia,T., Liao,Z. and Li,Z.S.
    Serine protease inhibitor Kazal type 1 (SPINK1) c.194+2T > C mutation may predict long-term outcome of endoscopic treatments in idiopathic chronic pancreatitis
    Medicine (Baltimore)94, e2046-e2046. PubMed  Europe PubMed DOI  M
    23. 2014
  23. Chang,M.C., Jan,I.S., Liang,P.C., Jeng,Y.M., Yang,C.Y., Tien,Y.W., Wong,J.M. and Chang,Y.T.
    Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis
    J Gastroenterol Hepatol29, 2038-2042. PubMed  Europe PubMed DOI  M
  24. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med232, 69-77. PubMed  Europe PubMed DOI  M
  25. Ravi Kanth,V. and Nageshwar Reddy,D.
    Genetics of acute and chronic pancreatitis: an update
    World J Gastrointest Pathophysiol5, 427-437. PubMed  Europe PubMed DOI  M
  26. Sakata,K., Ohmuraya,M., Araki,K., Suzuki,C., Ida,S., Hashimoto,D., Wang,J., Uchiyama,Y., Baba,H. and Yamamura,K.-I.
    Generation and analysis of serine protease inhibitor Kazal type 3-Cre driver mice
    Exp Anim63, 45-53. PubMed  Europe PubMed DOI
    27. 2013
  27. Assis,D.M., Zalazar,L., Juliano,M.A., Castro,R.D. and Cesari,A.
    Novel inhibitory activity for serine protease inhibitor Kazal type-3 (Spink3) on human recombinant kallikreins
    Protein Pept Lett20, 1098-1107. PubMed  Europe PubMed
  28. Mokmak,W., Chunsrivirot,S., Assawamakin,A., Choowongkomon,K. and Tongsima,S.
    Molecular dynamics simulations reveal structural instability of human trypsin inhibitor upon D50E and Y54H mutations
    J Mol Model19, 521-528. PubMed  Europe PubMed DOI
  29. Watson,P.J.
    Conflicting results of genetic studies looking at SPINK 1 mutations
    J Vet Intern Med27, 1291-1291. PubMed  Europe PubMed DOI  M
    30. 2012
  30. Romac,J.M., Shahid,R.A., Choi,S.S., Karaca,G.F., Westphalen,C.B., Wang,T.C. and Liddle,R.A.
    Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1beta in the pancreas
    Am J Physiol Gastrointest Liver Physiol302, G535-G541. PubMed  Europe PubMed DOI
  31. Zalazar,L., Saez Lancellotti,T.E., Clementi,M., Lombardo,C., Lamattina,L., De Castro,R., Fornes,M.W. and Cesari,A.
    SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity
    Reproduction143, 281-295. PubMed  Europe PubMed DOI
    32. 2011
  32. Ohmuraya,M. and Yamamura,K.
    Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases
    Exp Anim60, 433-444. PubMed  Europe PubMed DOI
  33. Sandhu,B., Vitazka,P., Ferreira-Gonzalez,A., Pandya,A., Vachhani,R., Bouhaidar,D., Zfass,A. and Sanyal,A.
    Presence of SPINK-1 variant alters the course of chronic pancreatitis
    J Gastroenterol Hepatol26, 965-969. PubMed  Europe PubMed DOI  M
  34. van Hoef,V., Breugelmans,B., Spit,J., Simonet,G., Zels,S., Billen,J. and Vanden Broeck,J.
    Functional analysis of a pancreatic secretory trypsin inhibitor-like protein in insects: silencing effects resemble the human pancreatic autodigestion phenotype
    Insect Biochem Mol Biol41, 688-695. PubMed  Europe PubMed DOI
    35. 2010
  35. Aoun,E., Muddana,V., Papachristou,G.I. and Whitcomb,D.C.
    SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event
    Am J Gastroenterol105, 446-451. PubMed  Europe PubMed DOI  M
  36. Bishop,M.A., Xenoulis,P.G., Levinski,M.D., Suchodolski,J.S. and Steiner,J.M.
    Identification of variants of the SPINK1 gene and their association with pancreatitis in Miniature Schnauzers
    Am J Vet Res71, 527-533. PubMed  Europe PubMed DOI  M
  37. Gasiorowska,A., Talar-Wojnarowska,R., Czupryniak,L., Smolarz,B., Romanowicz-Makowska,H., Kulig,A. and Malecka-Panas,E.
    Prevalence of the N34S mutation of SPINK1 (serine protease inhibitor, Kazal type 1) in patients with chronic pancreatitis and pancreatic cancer
    Prz Gastroenterol5, 214-221. DOI  M
  38. Ota,Y., Masamune,A., Inui,K., Kume,K., Shimosegawa,T. and Kikuyama,M.
    Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis
    Tohoku J Exp Med221, 197-201. PubMed  Europe PubMed DOI  M
  39. Romac,J.M., Ohmuraya,M., Bittner,C., Majeed,M.F., Vigna,S.R., Que,J., Fee,B.E., Wartmann,T., Yamamura,K. and Liddle,R.A.
    Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype
    Am J Physiol Gastrointest Liver Physiol298, G518-G524. PubMed  Europe PubMed DOI  K  U
  40. Wang,G.P. and Xu,C.S.
    Pancreatic secretory trypsin inhibitor: more than a trypsin inhibitor
    World J Gastrointest Pathophysiol1, 85-90. PubMed  Europe PubMed DOI
    41. 2009
  41. Ohmuraya,M., Ozaki,N., Hirota,M., Baba,H. and Yamamura,K.I.
    Serine protease inhibitor Kazal type 1 (SPINK1): beyond the trypsin inhibitor
    Curr Enzyme Inhib5, 110-116.  V
    42. 2008
  42. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.
    Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Periodontal Res43, 232-236. PubMed  Europe PubMed DOI
  43. O'Reilly,D.A., Witt,H., Rahman,S.H., Schulz,H.U., Sargen,K., Kage,A., Cartmell,M.T., Landt,O., Larvin,M., Demaine,A.G., McMahon,M.J., Becker,M. and Kingsnorth,A.N.
    The SPINK1 N34S variant is associated with acute pancreatitis
    Eur J Gastroenterol Hepatol20, 726-731. PubMed  Europe PubMed DOI  M
  44. Teich,N. and Mossner,J.
    Hereditary chronic pancreatitis
    Best Pract Res Clin Gastroenterol22, 115-130. PubMed  Europe PubMed DOI  V
    45. 2007
  45. Boulling,A., Le Marechal,C., Trouve,P., Raguenes,O., Chen,J.M. and Ferec,C.
    Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Eur J Hum Genet15, 936-942. PubMed  Europe PubMed DOI  M
  46. Kiraly,O., Boulling,A., Witt,H., Le Marechal,C., Chen,J.M., Rosendahl,J., Battaggia,C., Wartmann,T., Sahin-Toth,M. and Ferec,C.
    Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis
    Hum Mutat28, 469-476. PubMed  Europe PubMed DOI  M
  47. Masamune,A., Kume,K., Takagi,Y., Kikuta,K., Satoh,K., Satoh,A. and Shimosegawa,T.
    N34S mutation in the SPINK1 gene is not associated with alternative splicing
    Pancreas34, 423-428. PubMed  Europe PubMed DOI  M
  48. Oh,H.C., Lee,T.Y., Kwon,S., Lee,S.S., Seo,D.W., Lee,S.K. and Kim,M.H.
    [SPINK1 N34S mutation as a possible cause of chronic pancreatitis in a patient with familial background]
    Korean J Gastroenterol49, 384-389. PubMed  Europe PubMed  M
  49. Paju,A., Hotakainen,K., Cao,Y., Laurila,T., Gadaleanu,V., Hemminki,A., Stenman,U.H. and Bjartell,A.
    Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells
    Eur Urol52, 1670-1679. PubMed  Europe PubMed DOI
  50. Tzetis,M., Kaliakatsos,M., Fotoulaki,M., Papatheodorou,A., Doudounakis,S., Tsezou,A., Makrythanasis,P., Kanavakis,E. and Nousia-Arvanitakis,S.
    Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
    Clin Genet71, 451-457. PubMed  Europe PubMed DOI  M
  51. Wapenaar,M.C., Monsuur,A.J., Poell,J., van 't Slot,R., Meijer,J.W., Meijer,G.A., Mulder,C.J., Mearin,M.L. and Wijmenga,C.
    The SPINK gene family and celiac disease susceptibility
    Immunogenetics59, 349-357. PubMed  Europe PubMed DOI
    52. 2006
  52. [YEAR:1-3-2006]Chera,S., de Rosa,R., Miljkovic-Licina,M., Dobretz,K., Ghila,L., Kaloulis,K. and Galliot,B.
    Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype
    J Cell Sci119, 846-857. PubMed  Europe PubMed DOI
  53. [YEAR:7-9-2006]Kalinin,V.N., Kaifi,J.T., Schwarzenbach,H., Sergeyev,A.S., Link,B.C., Bogoevski,D., Vashist,Y., Izbicki,J.R. and Yekebas,E.F.
    Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients
    World J Gastroenterol12, 5352-5356. PubMed  Europe PubMed  M
  54. [YEAR:5-7-2006]Masson,E., Le Marechal,C., Chen,J.M., Frebourg,T., Lerebours,E. and Ferec,C.
    Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Eur J Hum Genet14, 1204-1208. PubMed  Europe PubMed DOI  M
    55. 2005
  55. [YEAR:23-6-2005]Kume,K., Masamune,A., Mizutamari,H., Kaneko,K., Kikuta,K., Satoh,M., Satoh,K., Kimura,K., Suzuki,N., Nagasaki,Y., Horii,A. and Shimosegawa,T.
    Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis
    Pancreatology5, 354-360. PubMed  Europe PubMed DOI
  56. Nathan,J.D., Romac,J., Peng,R.Y., Peyton,M., Macdonald,R.J. and Liddle,R.A.
    Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice
    Gastroenterology128, 717-727. PubMed  Europe PubMed DOI
  57. Ohmuraya,M., Hirota,M., Araki,M., Mizushima,N., Matsui,M., Mizumoto,T., Haruna,K., Kume,S., Takeya,M., Ogawa,M., Araki,K. and Yamamura,K.
    Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    Gastroenterology129, 696-705. PubMed  Europe PubMed DOI  K
  58. Schneider,A., Lawrence,E.C., Barmada,M.M., Norris,J.M., Hamman,R.F., Marshall,J.A., Ferrell,R.E. and Whitcomb,D.C.
    The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA
    Diabet Med22, 744-748. PubMed  Europe PubMed DOI
  59. [YEAR:14-6-2005]Shariat,S.F., Herman,M.P., Casella,R., Lotan,Y., Karam,J.A. and Stenman,U.H.
    Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder
    Eur Urol48, 424-431. PubMed  Europe PubMed DOI
  60. Tukiainen,E., Kylanpaa,M.L., Kemppainen,E., Nevanlinna,H., Paju,A., Repo,H., Stenman,U.H. and Puolakkainen,P.
    Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis
    Pancreas30, 239-242. PubMed  Europe PubMed DOI
  61. Wiksten,J.P., Lundin,J., Nordling,S., Kokkola,A., Stenman,U.H. and Haglund,C.
    High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer
    Histopathology46, 380-388. PubMed  Europe PubMed DOI
    62. 2004
  62. Chandak,G.R., Idris,M.M., Reddy,D.N., Mani,K.R., Bhaskar,S., Rao,G.V. and Singh,L.
    Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
    Gut53, 723-728. PubMed  Europe PubMed DOI
  63. Le Marechal,C., Chen,J.M., Le Gall,C., Plessis,G., Chipponi,J., Chuzhanova,N.A., Raguenes,O. and Ferec,C.
    Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis
    Hum Mutat23, 205-205. PubMed  Europe PubMed DOI
  64. [YEAR:15-7-2004]Paju,A., Vartiainen,J., Haglund,C., Itkonen,O., von Boguslawski,K., Leminen,A., Wahlstrom,T. and Stenman,U.H.
    Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum
    Clin Cancer Res10, 4761-4768. PubMed  Europe PubMed DOI
  65. Panda,H., Zaidi,G. and Supakar,P.C.
    Decreased expression of the pancreatic secretory trypsin inhibitor II gene during aging of the rat liver
    J Biomed Sci11, 528-530. PubMed  Europe PubMed DOI
  66. Schneider,A.
    Serine protease inhibitor Kazal type 1 mutations and pancreatitis
    Gastroenterol Clin North Am33, 789-806. PubMed  Europe PubMed DOI  M
    67. 2003
  67. Kelloniemi,E., Rintala,E., Finne,P. and Stenman,U.H.
    Tumor-associated trypsin inhibitor as a prognostic factor during follow-up of bladder cancer
    Urology62, 249-253. PubMed  Europe PubMed DOI
  68. [YEAR:15-5-2003]Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H., Iwanaga,T. and Fushiki,T.
    Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A
    Biochem J372, 227-233. PubMed  Europe PubMed DOI
    69. 2002
  69. Bhatia,E., Choudhuri,G., Sikora,S.S., Landt,O., Kage,A., Becker,M. and Witt,H.
    Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations
    Gastroenterology123, 1020-1025. PubMed  Europe PubMed DOI
  70. Chandak,G.R., Idris,M.M., Reddy,D.N., Bhaskar,S., Sriram,P.V. and Singh,L.
    Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis
    J Med Genet39, 347-351. PubMed  Europe PubMed
  71. Drenth,J.P., te Morsche,R. and Jansen,J.B.
    Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis
    Gut50, 687-692. PubMed  Europe PubMed DOI
  72. Stenman,U.H.
    Tumor-associated trypsin inhibitor
    Clin Chem48, 1206-1209. PubMed  Europe PubMed
  73. Teich,N., Bauer,N., Mossner,J. and Keim,V.
    Mutational screening of patients with nonalcoholic chronic pancreatitis: Identification of further trypsinogen variants
    Am J Gastroenterol97, 341-346. PubMed  Europe PubMed DOI
  74. Truninger,K., Witt,H., Kock,J., Kage,A., Seifert,B., Ammann,R.W., Blum,H.E. and Becker,M.
    Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis
    Am J Gastroenterol97, 1133-1137. PubMed  Europe PubMed DOI
    75. 2001
  75. Pfutzer,R.H. and Whitcomb,D.C.
    SPINK1 mutations are associated with multiple phenotypes
    Pancreatology1, 457-460. PubMed  Europe PubMed DOI  M
  76. [YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L.
    Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis
    J Biol Chem276, 24574-24580. PubMed  Europe PubMed DOI
    77. 2000
  77. Pfutzer,R.H., Barmada,M.M., Brunskill,A.P., Finch,R., Hart,P.S., Neoptolemos,J., Furey,W.F. and Whitcomb,D.C.
    SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    Gastroenterology119, 615-623. PubMed  Europe PubMed  M
  78. Witt,H., Luck,W., Hennies,H.C., Classen,M., Kage,A., Lass,U., Landt,O. and Becker,M.
    Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
    Nat Genet25, 213-216. PubMed  Europe PubMed DOI  M
    79. 1998
  79. [YEAR:18-12-1998]Yasuda,T., Yasuda,T., Ohmachi,Y., Katsuki,M., Yokoyama,M., Murata,A., Monden,M. and Matsubara,K.
    Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene
    J Biol Chem273, 34413-34421. PubMed  Europe PubMed DOI
    80. 1997
  80. Katoh,T., Tamaki,M., Kikuchi,N., Teraoka,H., Nagata,K. and Yoshida,N.
    Mutations within the reactive-site region of human pancreatic secretory trypsin inhibitor confer alpha-thrombin and factor Xa inhibitory activities
    Biosci Biotechnol Biochem61, 389-391. PubMed  Europe PubMed DOI
    81. 1996
  81. Chen,Y.Z., Ikei,S., Yamaguchi,Y., Sameshima,H., Sugita,H., Moriyasu,M. and Ogawa,M.
    The protective effects of long-acting recombinant human pancreatic secretory trypsin inhibitor (R44S-PSTI) in a rat model of cerulein-induced pancreatitis
    J Int Med Res24, 59-68. PubMed  Europe PubMed
    82. 1995
  82. Medl,M., Ogris,E., Peters-Engl,C. and Leodolter,S.
    TATI (tumour-associated trypsin inhibitor) as a marker of ovarian cancer
    Br J Cancer71, 1051-1054. PubMed  Europe PubMed
  83. Szardenings,M., Vasel,B., Hecht,H.J., Collins,J. and Schomburg,D.
    Highly effective protease inhibitors from variants of human pancreatic secretory trypsin inhibitor (hPSTI): an assessment of 3-D structure-based protein design
    Protein Eng8, 45-52. PubMed  Europe PubMed
    84. 1993
  84. [YEAR:5-2-1993]Klaus,W. and Schomburg,D.
    Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy
    J Mol Biol229, 695-706. PubMed  Europe PubMed DOI  S
    85. 1992
  85. [YEAR:20-6-1992]Hecht,H.J., Szardenings,M., Collins,J. and Schomburg,D.
    Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)
    J Mol Biol225, 1095-1103. PubMed  Europe PubMed DOI  S
    86. 1991
  86. Hecht,H.J., Szardenings,M., Collins,J. and Schomburg,D.
    Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type)
    J Mol Biol220, 711-722. PubMed  Europe PubMed  S
  87. Stenman,U.H., Koivunen,E. and Itkonen,O.
    Biology and function of tumor-associated trypsin inhibitor, TATI
    Scand J Clin Lab Invest Suppl207, 5-9. PubMed  Europe PubMed
    88. 1982
  88. [YEAR:25-12-1982]Bolognesi,M., Gatti,G., Menagatti,E., Guarneri,M., Marquart,M., Papamokos,E. and Huber,R.
    Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation
    J Mol Biol162, 839-868. PubMed  Europe PubMed  S
    89. 1974
  89. Pubols,M.H., Bartelt,D.C. and Greene,L.J.
    Trypsin inhibitor from human pancreas and pancreatic juice
    J Biol Chem249, 2235-2242. PubMed  Europe PubMed
    90. 1973
  90. [YEAR:14-8-1973]Sealock,R.W. and Laskowski,M., Jr.
    Thermodynamics and kinetics of the reactive site peptide-bond hydrolysis in bovine pancreatic secretory trypsin inhibitor (Kazal)
    Biochemistry12, 3139-3146. PubMed  Europe PubMed
    91. 1970
  91. Tschesche,H. and Haenisch,G.
    Regeneration of native structure and biological activity by air oxidation of reduced pancreatic secretory trypsin inhibitor and Des-Thr-Ser-Pro-Gln-Arg-inhibitor
    FEBS Lett11, 209-212. PubMed  Europe PubMed
    92. 1969
  92. [YEAR:25-5-1969]Greene,L.J. and Bartelt,D.C.
    The structure of the bovine pancreatic secretory trypsin inhibitor - Kazal's inhibitor. II. The order of the tryptic peptides
    J Biol Chem244, 2646-2657. PubMed  Europe PubMed

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