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Literature for inhibitor I01.011: SPINK1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibits

(Topics flags: S Structure, M Mutation, K Knockout, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Nicolli,A.R., Huang,X., Zalazar,L., Stival,C., Gomez-Olivieri,L.R., Demare,G., Romarowski,A., Buffone,M.G., Krapf,D., Chung,J.J. and Cesari,A.
    SPINK3-Sperm Interaction Determines a Stable Sperm Subpopulation With Intact CatSper Channel
    J Cell Physiol (2026) 241, e70138-e70138. PubMed  Europe PubMed DOI
    2. 2025
  2. Berke,G. and Sahin-Toth,M.
    Minigenes enhance heterologous expression and prevent aberrant splicing of mouse Spink1
    Sci Rep (2025) 15, 28222-28222. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Wang,Q.W., Zou,W.B., Masson,E., Ferec,C., Liao,Z. and Chen,J.M.
    Genetics and clinical implications of SPINK1 in the pancreatitis continuum and pancreatic cancer
    Hum Genomics (2025) 19, 32-32. PubMed  Europe PubMed DOI  PMC  EPMC  V
    4. 2024
  4. Demcsak,A. and Sahin-Toth,M.
    Heterozygous Spink1 deficiency promotes trypsin-dependent chronic pancreatitis in mice
    Cell Mol Gastroenterol Hepatol (2024) 18, 101361-101361. PubMed  Europe PubMed DOI
  5. Lu,F., Ott,C., Bista,P. and Lu,X.
    Three-Dimensional Structure of Novel Liver Cancer Biomarker Liver Cancer-Specific Serine Protease Inhibitor Kazal (LC-SPIK) and Its Performance in Clinical Diagnosis of Hepatocellular Carcinoma (HCC)
    Diagnostics (Basel) (2024) 14 PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2023
  6. Nagel,F., Susemihl,A., Eulberg,T. and Delcea,M.
    Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties
    Biochemistry (2023) 62, 535-542. PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Chen,Y.T., Tseng,T.T., Tsai,H.P., Kuo,S.H., Huang,M.Y., Wang,J.Y. and Chai,C.Y.
    Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine
    Hum Cell (2022) 35, 1912-1927. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Nicolli,A.R., Alonso,C.A.I., Otamendi,C., Cerletti,M., Poetsch,A., Sharma,V., Zalazar,L., Perez-Martinez,S. and Cesari,A.
    How, where and when is SPINK3 bound and removed from mouse sperm?
    Reproduction (2022) 163, 251-266. PubMed  Europe PubMed DOI
    9. 2021
  9. Akhmedov,V.A. and Gaus,O.V.
    [Inflammatory diseases of the pancreas: what new do we know about the mechanisms of their development in the 21st century?]
    Ter Arkh (2021) 93, 66-70. PubMed  Europe PubMed DOI
  10. Lin,T.C.
    Functional Roles of SPINK1 in Cancers
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  11. Szabo,A., Toldi,V., Gazda,L.D., Demcsak,A., Tozser,J. and Sahin-Toth,M.
    Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis
    J Biol Chem (2021) , 100343-100343. PubMed  Europe PubMed DOI
    12. 2020
  12. Felicelli,C. and Pezhouh,M.K.
    Histopathology of SPINK-1 Hereditary Pancreatitis
    Int J Surg Pathol (2020) , 1066896920980086-1066896920980086. PubMed  Europe PubMed DOI
  13. Girodon,E., Rebours,V., Chen,J.M., Pagin,A., Levy,P., Ferec,C. and Bienvenu,T.
    Clinical interpretation of SPINK1 and CTRC variants in pancreatitis
    Pancreatology (2020) 20, 1354-1367. PubMed  Europe PubMed DOI  V
  14. Ni Chonchubhair,H.M., Duggan,S.N., Egan,S.M., Kenyon,M., O'Toole,D., McManus,R. and Conlon,K.C.
    A high prevalence of genetic polymorphisms in idiopathic and alcohol-associated chronic pancreatitis patients in Ireland
    HPB (Oxford) (2020) PubMed  Europe PubMed DOI
  15. Tornberg,S.V., Nisen,H., Jarvinen,P., Jarvinen,R., Kilpelainen,T.P., Taari,K., Stenman,U.H. and Visapaa,H.
    Serum tumour associated trypsin inhibitor, as a biomarker for survival in renal cell carcinoma
    Scand J Urol (2020) , 1-7. PubMed  Europe PubMed DOI
  16. Wang,Z.C., Li,Y., Wang,K.L., Wang,L., You,B.S., Zhao,D.F., Liu,Z.Q., Fang,R.Z., Wang,J.Q., Zhang,W., Zhang,J.M. and Xu,W.H.
    miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling
    Aging (Albany NY) (2020) 12, 14418-14433. PubMed  Europe PubMed DOI  K
    17. 2019
  17. Buchholz,I., Nagel,F., Klein,A., Wagh,P.R., Mahajan,U.M., Greinacher,A., Lerch,M.M., Mayerle,J. and Delcea,M.
    The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant
    Biochim Biophys Acta Proteins Proteom (2019) , 140281-140281. PubMed  Europe PubMed DOI  M
    18. 2018
  18. Hama,T., Nakanishi,N., Suzuki,M., Shima,Y. and Suzuki,H.
    Serine protease inhibitor Kazal type I (SPINK1) mutation: a risk factor for early-onset chronic pancreatitis?
    J Pediatr Gastroenterol Nutr (2018) 67, e40-e40. PubMed  Europe PubMed DOI  M
    19. 2017
  19. Patel,J., Madan,A., Gammon,A., Sossenheimer,M. and Samadder,N.J.
    Rare hereditary cause of chronic pancreatitis in a young male: SPINK1 mutation
    Pan Afr Med J (2017) 28, 110-110. PubMed  Europe PubMed DOI  PMC  EPMC  M
    20. 2016
  20. da Costa,M.Z., Pires,J.G., Nasser,P.D., Ferreira,C.D., Teixeira,A.C., Paranagua-Vezozzo,D.C., Guarita,D.R., Carrilho,F.J. and Ono,S.K.
    Frequency of tabagism and N34S and P55S mutations of serine peptidase inhibitor, Kazal type 1 (SPINK1) and R254W mutation of chymotrypsin C (CTRC) in patients with chronic pancreatitis and controls
    Pancreas (2016) 45, 1330-1335. PubMed  Europe PubMed DOI  M
  21. Sakata,K., Araki,K., Nakano,H., Nishina,T., Komazawa-Sakon,S., Murai,S., Lee,G.E., Hashimoto,D., Suzuki,C., Uchiyama,Y., Notohara,K., Gukovskaya,A.S., Gukovsky,I., Yamamura,K.I., Baba,H. and Ohmuraya,M.
    Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
    Sci Rep (2016) 6, 37200-37200. PubMed  Europe PubMed DOI
  22. Zhang,J., Wang,D., Hu,N., Wang,Q., Yu,S. and Wang,J.
    The construction and proliferative effects of a lentiviral vector capable of stably overexpressing SPINK1 gene in human pancreatic cancer AsPC-1 cell line
    Tumour Biol (2016) 37, 5847-5855. PubMed  Europe PubMed DOI  E
    23. 2015
  23. Kumaresan,V., Harikrishnan,R. and Arockiaraj,J.
    A potential Kazal-type serine protease inhibitor involves in kinetics of protease inhibition and bacteriostatic activity
    Fish Shellfish Immunol (2015) 42, 430-438. PubMed  Europe PubMed DOI
  24. Sun,C., Liu,M.Y., Liu,X.G., Hu,L.H., Xia,T., Liao,Z. and Li,Z.S.
    Serine protease inhibitor Kazal type 1 (SPINK1) c.194+2T > C mutation may predict long-term outcome of endoscopic treatments in idiopathic chronic pancreatitis
    Medicine (Baltimore) (2015) 94, e2046-e2046. PubMed  Europe PubMed DOI  M
    25. 2014
  25. Chang,M.C., Jan,I.S., Liang,P.C., Jeng,Y.M., Yang,C.Y., Tien,Y.W., Wong,J.M. and Chang,Y.T.
    Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis
    J Gastroenterol Hepatol (2014) 29, 2038-2042. PubMed  Europe PubMed DOI  M
  26. Masamune,A.
    Genetics of pancreatitis: the 2014 update
    Tohoku J Exp Med (2014) 232, 69-77. PubMed  Europe PubMed DOI  M
  27. Ravi Kanth,V. and Nageshwar Reddy,D.
    Genetics of acute and chronic pancreatitis: an update
    World J Gastrointest Pathophysiol (2014) 5, 427-437. PubMed  Europe PubMed DOI  PMC  EPMC  M
  28. Sakata,K., Ohmuraya,M., Araki,K., Suzuki,C., Ida,S., Hashimoto,D., Wang,J., Uchiyama,Y., Baba,H. and Yamamura,K.-I.
    Generation and analysis of serine protease inhibitor Kazal type 3-Cre driver mice
    Exp Anim (2014) 63, 45-53. PubMed  Europe PubMed DOI
    29. 2013
  29. Assis,D.M., Zalazar,L., Juliano,M.A., Castro,R.D. and Cesari,A.
    Novel inhibitory activity for serine protease inhibitor Kazal type-3 (Spink3) on human recombinant kallikreins
    Protein Pept Lett (2013) 20, 1098-1107. PubMed  Europe PubMed
  30. Mokmak,W., Chunsrivirot,S., Assawamakin,A., Choowongkomon,K. and Tongsima,S.
    Molecular dynamics simulations reveal structural instability of human trypsin inhibitor upon D50E and Y54H mutations
    J Mol Model (2013) 19, 521-528. PubMed  Europe PubMed DOI
  31. Watson,P.J.
    Conflicting results of genetic studies looking at SPINK 1 mutations
    J Vet Intern Med (2013) 27, 1291-1291. PubMed  Europe PubMed DOI  M
    32. 2012
  32. Romac,J.M., Shahid,R.A., Choi,S.S., Karaca,G.F., Westphalen,C.B., Wang,T.C. and Liddle,R.A.
    Pancreatic secretory trypsin inhibitor I reduces the severity of chronic pancreatitis in mice overexpressing interleukin-1beta in the pancreas
    Am J Physiol Gastrointest Liver Physiol (2012) 302, G535-G541. PubMed  Europe PubMed DOI
  33. Zalazar,L., Saez Lancellotti,T.E., Clementi,M., Lombardo,C., Lamattina,L., De Castro,R., Fornes,M.W. and Cesari,A.
    SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity
    Reproduction (2012) 143, 281-295. PubMed  Europe PubMed DOI
    34. 2011
  34. Ohmuraya,M. and Yamamura,K.
    Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases
    Exp Anim (2011) 60, 433-444. PubMed  Europe PubMed DOI
  35. Sandhu,B., Vitazka,P., Ferreira-Gonzalez,A., Pandya,A., Vachhani,R., Bouhaidar,D., Zfass,A. and Sanyal,A.
    Presence of SPINK-1 variant alters the course of chronic pancreatitis
    J Gastroenterol Hepatol (2011) 26, 965-969. PubMed  Europe PubMed DOI  M
  36. van Hoef,V., Breugelmans,B., Spit,J., Simonet,G., Zels,S., Billen,J. and Vanden Broeck,J.
    Functional analysis of a pancreatic secretory trypsin inhibitor-like protein in insects: silencing effects resemble the human pancreatic autodigestion phenotype
    Insect Biochem Mol Biol (2011) 41, 688-695. PubMed  Europe PubMed DOI
    37. 2010
  37. Aoun,E., Muddana,V., Papachristou,G.I. and Whitcomb,D.C.
    SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event
    Am J Gastroenterol (2010) 105, 446-451. PubMed  Europe PubMed DOI  M
  38. Bishop,M.A., Xenoulis,P.G., Levinski,M.D., Suchodolski,J.S. and Steiner,J.M.
    Identification of variants of the SPINK1 gene and their association with pancreatitis in Miniature Schnauzers
    Am J Vet Res (2010) 71, 527-533. PubMed  Europe PubMed DOI  M
  39. Gasiorowska,A., Talar-Wojnarowska,R., Czupryniak,L., Smolarz,B., Romanowicz-Makowska,H., Kulig,A. and Malecka-Panas,E.
    Prevalence of the N34S mutation of SPINK1 (serine protease inhibitor, Kazal type 1) in patients with chronic pancreatitis and pancreatic cancer
    Prz Gastroenterol (2010) 5, 214-221. DOI  M
  40. Ota,Y., Masamune,A., Inui,K., Kume,K., Shimosegawa,T. and Kikuyama,M.
    Phenotypic variability of the homozygous IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene in patients with chronic pancreatitis
    Tohoku J Exp Med (2010) 221, 197-201. PubMed  Europe PubMed DOI  M
  41. Romac,J.M., Ohmuraya,M., Bittner,C., Majeed,M.F., Vigna,S.R., Que,J., Fee,B.E., Wartmann,T., Yamamura,K. and Liddle,R.A.
    Transgenic expression of pancreatic secretory trypsin inhibitor-1 rescues SPINK3-deficient mice and restores a normal pancreatic phenotype
    Am J Physiol Gastrointest Liver Physiol (2010) 298, G518-G524. PubMed  Europe PubMed DOI  K  U
  42. Wang,G.P. and Xu,C.S.
    Pancreatic secretory trypsin inhibitor: more than a trypsin inhibitor
    World J Gastrointest Pathophysiol (2010) 1, 85-90. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2009
  43. Ohmuraya,M., Ozaki,N., Hirota,M., Baba,H. and Yamamura,K.I.
    Serine protease inhibitor Kazal type 1 (SPINK1): beyond the trypsin inhibitor
    Curr Enzyme Inhib (2009) 5, 110-116.  V
    44. 2008
  44. Bania,J., Kubiak,A., Wojtachnio,K. and Polanowski,A.
    Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis
    J Periodontal Res (2008) 43, 232-236. PubMed  Europe PubMed DOI
  45. O'Reilly,D.A., Witt,H., Rahman,S.H., Schulz,H.U., Sargen,K., Kage,A., Cartmell,M.T., Landt,O., Larvin,M., Demaine,A.G., McMahon,M.J., Becker,M. and Kingsnorth,A.N.
    The SPINK1 N34S variant is associated with acute pancreatitis
    Eur J Gastroenterol Hepatol (2008) 20, 726-731. PubMed  Europe PubMed DOI  M
  46. Teich,N. and Mossner,J.
    Hereditary chronic pancreatitis
    Best Pract Res Clin Gastroenterol (2008) 22, 115-130. PubMed  Europe PubMed DOI  V
    47. 2007
  47. Boulling,A., Le Marechal,C., Trouve,P., Raguenes,O., Chen,J.M. and Ferec,C.
    Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Eur J Hum Genet (2007) 15, 936-942. PubMed  Europe PubMed DOI  M
  48. Kiraly,O., Boulling,A., Witt,H., Le Marechal,C., Chen,J.M., Rosendahl,J., Battaggia,C., Wartmann,T., Sahin-Toth,M. and Ferec,C.
    Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis
    Hum Mutat (2007) 28, 469-476. PubMed  Europe PubMed DOI  PMC  EPMC  M
  49. Masamune,A., Kume,K., Takagi,Y., Kikuta,K., Satoh,K., Satoh,A. and Shimosegawa,T.
    N34S mutation in the SPINK1 gene is not associated with alternative splicing
    Pancreas (2007) 34, 423-428. PubMed  Europe PubMed DOI  M
  50. Oh,H.C., Lee,T.Y., Kwon,S., Lee,S.S., Seo,D.W., Lee,S.K. and Kim,M.H.
    [SPINK1 N34S mutation as a possible cause of chronic pancreatitis in a patient with familial background]
    Korean J Gastroenterol (2007) 49, 384-389. PubMed  Europe PubMed  M
  51. Paju,A., Hotakainen,K., Cao,Y., Laurila,T., Gadaleanu,V., Hemminki,A., Stenman,U.H. and Bjartell,A.
    Increased expression of tumor-associated trypsin inhibitor, TATI, in prostate cancer and in androgen-independent 22Rv1 cells
    Eur Urol (2007) 52, 1670-1679. PubMed  Europe PubMed DOI
  52. Tzetis,M., Kaliakatsos,M., Fotoulaki,M., Papatheodorou,A., Doudounakis,S., Tsezou,A., Makrythanasis,P., Kanavakis,E. and Nousia-Arvanitakis,S.
    Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
    Clin Genet (2007) 71, 451-457. PubMed  Europe PubMed DOI  M
  53. Wapenaar,M.C., Monsuur,A.J., Poell,J., van 't Slot,R., Meijer,J.W., Meijer,G.A., Mulder,C.J., Mearin,M.L. and Wijmenga,C.
    The SPINK gene family and celiac disease susceptibility
    Immunogenetics (2007) 59, 349-357. PubMed  Europe PubMed DOI  PMC  EPMC
    54. 2006
  54. [YEAR:1-3-2006]Chera,S., de Rosa,R., Miljkovic-Licina,M., Dobretz,K., Ghila,L., Kaloulis,K. and Galliot,B.
    Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype
    J Cell Sci (1-3-2006) 119, 846-857. PubMed  Europe PubMed DOI
  55. [YEAR:7-9-2006]Kalinin,V.N., Kaifi,J.T., Schwarzenbach,H., Sergeyev,A.S., Link,B.C., Bogoevski,D., Vashist,Y., Izbicki,J.R. and Yekebas,E.F.
    Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients
    World J Gastroenterol (7-9-2006) 12, 5352-5356. PubMed  Europe PubMed  M
  56. [YEAR:5-7-2006]Masson,E., Le Marechal,C., Chen,J.M., Frebourg,T., Lerebours,E. and Ferec,C.
    Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene
    Eur J Hum Genet (5-7-2006) 14, 1204-1208. PubMed  Europe PubMed DOI  M
    57. 2005
  57. [YEAR:23-6-2005]Kume,K., Masamune,A., Mizutamari,H., Kaneko,K., Kikuta,K., Satoh,M., Satoh,K., Kimura,K., Suzuki,N., Nagasaki,Y., Horii,A. and Shimosegawa,T.
    Mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in Japanese patients with pancreatitis
    Pancreatology (23-6-2005) 5, 354-360. PubMed  Europe PubMed DOI
  58. Nathan,J.D., Romac,J., Peng,R.Y., Peyton,M., Macdonald,R.J. and Liddle,R.A.
    Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice
    Gastroenterology (2005) 128, 717-727. PubMed  Europe PubMed DOI
  59. Ohmuraya,M., Hirota,M., Araki,M., Mizushima,N., Matsui,M., Mizumoto,T., Haruna,K., Kume,S., Takeya,M., Ogawa,M., Araki,K. and Yamamura,K.
    Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    Gastroenterology (2005) 129, 696-705. PubMed  Europe PubMed DOI  K
  60. Schneider,A., Lawrence,E.C., Barmada,M.M., Norris,J.M., Hamman,R.F., Marshall,J.A., Ferrell,R.E. and Whitcomb,D.C.
    The SPINK1 N34S mutation is not associated with Type 2 diabetes mellitus in a population of the USA
    Diabet Med (2005) 22, 744-748. PubMed  Europe PubMed DOI
  61. [YEAR:14-6-2005]Shariat,S.F., Herman,M.P., Casella,R., Lotan,Y., Karam,J.A. and Stenman,U.H.
    Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder
    Eur Urol (14-6-2005) 48, 424-431. PubMed  Europe PubMed DOI
  62. Tukiainen,E., Kylanpaa,M.L., Kemppainen,E., Nevanlinna,H., Paju,A., Repo,H., Stenman,U.H. and Puolakkainen,P.
    Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis
    Pancreas (2005) 30, 239-242. PubMed  Europe PubMed DOI
  63. Wiksten,J.P., Lundin,J., Nordling,S., Kokkola,A., Stenman,U.H. and Haglund,C.
    High tissue expression of tumour-associated trypsin inhibitor (TATI) associates with a more favourable prognosis in gastric cancer
    Histopathology (2005) 46, 380-388. PubMed  Europe PubMed DOI
    64. 2004
  64. Chandak,G.R., Idris,M.M., Reddy,D.N., Mani,K.R., Bhaskar,S., Rao,G.V. and Singh,L.
    Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis
    Gut (2004) 53, 723-728. PubMed  Europe PubMed DOI  PMC  EPMC
  65. Le Marechal,C., Chen,J.M., Le Gall,C., Plessis,G., Chipponi,J., Chuzhanova,N.A., Raguenes,O. and Ferec,C.
    Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis
    Hum Mutat (2004) 23, 205-205. PubMed  Europe PubMed DOI
  66. [YEAR:15-7-2004]Paju,A., Vartiainen,J., Haglund,C., Itkonen,O., von Boguslawski,K., Leminen,A., Wahlstrom,T. and Stenman,U.H.
    Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum
    Clin Cancer Res (15-7-2004) 10, 4761-4768. PubMed  Europe PubMed DOI
  67. Panda,H., Zaidi,G. and Supakar,P.C.
    Decreased expression of the pancreatic secretory trypsin inhibitor II gene during aging of the rat liver
    J Biomed Sci (2004) 11, 528-530. PubMed  Europe PubMed DOI
  68. Schneider,A.
    Serine protease inhibitor Kazal type 1 mutations and pancreatitis
    Gastroenterol Clin North Am (2004) 33, 789-806. PubMed  Europe PubMed DOI  M
    69. 2003
  69. Kelloniemi,E., Rintala,E., Finne,P. and Stenman,U.H.
    Tumor-associated trypsin inhibitor as a prognostic factor during follow-up of bladder cancer
    Urology (2003) 62, 249-253. PubMed  Europe PubMed DOI
  70. [YEAR:15-5-2003]Tsuzuki,S., Kokado,Y., Satomi,S., Yamasaki,Y., Hirayasu,H., Iwanaga,T. and Fushiki,T.
    Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A
    Biochem J (15-5-2003) 372, 227-233. PubMed  Europe PubMed DOI  PMC  EPMC
    71. 2002
  71. Bhatia,E., Choudhuri,G., Sikora,S.S., Landt,O., Kage,A., Becker,M. and Witt,H.
    Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations
    Gastroenterology (2002) 123, 1020-1025. PubMed  Europe PubMed DOI
  72. Chandak,G.R., Idris,M.M., Reddy,D.N., Bhaskar,S., Sriram,P.V. and Singh,L.
    Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis
    J Med Genet (2002) 39, 347-351. PubMed  Europe PubMed  PMC  EPMC
  73. Drenth,J.P., te Morsche,R. and Jansen,J.B.
    Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis
    Gut (2002) 50, 687-692. PubMed  Europe PubMed DOI  PMC  EPMC
  74. Stenman,U.H.
    Tumor-associated trypsin inhibitor
    Clin Chem (2002) 48, 1206-1209. PubMed  Europe PubMed
  75. Teich,N., Bauer,N., Mossner,J. and Keim,V.
    Mutational screening of patients with nonalcoholic chronic pancreatitis: Identification of further trypsinogen variants
    Am J Gastroenterol (2002) 97, 341-346. PubMed  Europe PubMed DOI
  76. Truninger,K., Witt,H., Kock,J., Kage,A., Seifert,B., Ammann,R.W., Blum,H.E. and Becker,M.
    Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis
    Am J Gastroenterol (2002) 97, 1133-1137. PubMed  Europe PubMed DOI
    77. 2001
  77. Pfutzer,R.H. and Whitcomb,D.C.
    SPINK1 mutations are associated with multiple phenotypes
    Pancreatology (2001) 1, 457-460. PubMed  Europe PubMed DOI  M
  78. [YEAR:6-7-2001]Szilagyi,L., Kenesi,E., Katona,G., Kaslik,G., Juhasz,G. and Graf,L.
    Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis
    J Biol Chem (6-7-2001) 276, 24574-24580. PubMed  Europe PubMed DOI
    79. 2000
  79. Pfutzer,R.H., Barmada,M.M., Brunskill,A.P., Finch,R., Hart,P.S., Neoptolemos,J., Furey,W.F. and Whitcomb,D.C.
    SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis
    Gastroenterology (2000) 119, 615-623. PubMed  Europe PubMed  M
  80. Witt,H., Luck,W., Hennies,H.C., Classen,M., Kage,A., Lass,U., Landt,O. and Becker,M.
    Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
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