Family I78

Family

Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

Summary for family I78

Family type peptidase	I78.001 - Aspergillus elastase inhibitor (Aspergillus fumigatus), MEROPS Accession MER0059865 (inhibitor unit: 20-87)
Content of family	Inhibitor family I78 contains inhibitors of serine-type endopeptidases.
History	Identifier created: MEROPS 8.2 (4 August 2008) Inhibitors of the fungal elastase oryzin (S08.053) were first detected in Aspergillus species by Okumura et al., 2004.
Peptidases inhibited	Oryzin and elastase 2 (S01.131) from leukocytes are inhibited, but not pancreatic elastases (e.g. S01.153), or metallo-elastases such as pseudolysin (M04.005) and snake venom elastase Okumura et al., 2008.
Molecular structure
Clan	unassigned

Distribution of family	Bacteria	details
	Archaea	-
	Protozoa	-
	Fungi	-
	Plants	details
	Animals	-
	Viruses	-

Biological functions
Pharmaceutical and biotech relevance	The Aspergillus flavus inhibitor has been shown to reduce bleeding in the lungs of infected rats and may therefore be beneficial in the treatment of aspergillosis (Okumura et al., 2008).
Statistics for family I78	Sequences:	96
	Identifiers:	1
	Identifiers with PDB entries:	1
Downloadable files	Sequence library (FastA format)
	Sequence alignment (FastA format)
	Phylogenetic tree (Newick format)

Other databases	INTERPRO	IPR021719
	PFAM	PF11720

Inhibitors and Homologues	MEROPS ID	Structure
Aspergillus elastase inhibitor	I78.001	Yes
Family I78 non-peptidase homologues	non-peptidase homologue	-
Family I78 unassigned peptidases	unassigned	-