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CHEBI:87632 - statin (naturally occurring)
| ChEBI ID | CHEBI:87632 |
| ChEBI Name | statin (naturally occurring) |
| Stars | |
| Definition | Any statin that occurs in nature. The class includes compactin (also known as mevastatin), isolated from a fermentation broth of Penicillium citrinum, and lovastatin, isolated from Aspergillus terreus. |
| Last Modified | 24 August 2015 |
| Submitter | Gareth Owen |
| Roles Classification |
|---|
| Biological Roles: | metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD+ or NADP+ acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme. |
| Application: | anticholesteremic drug A substance used to lower plasma cholesterol levels. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| statin (naturally occurring) (CHEBI:87632) has role metabolite (CHEBI:25212) |
| statin (naturally occurring) (CHEBI:87632) is a statin (CHEBI:87631) |
| Incoming Relation(s) |
| lovastatin (CHEBI:40303) is a statin (naturally occurring) (CHEBI:87632) |
| mevastatin (CHEBI:34848) is a statin (naturally occurring) (CHEBI:87632) |
| Synonyms | Source |
|---|---|
| statins (naturally occurring) | ChEBI |
| naturally occurring statin | ChEBI |
| naturally occurring statins | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| WO9832751 | Patent |
| Citations |
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