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CHEBI:47499 - imipramine

ChEBI IDCHEBI:47499
ChEBI Nameimipramine
Stars
DefinitionA dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Secondary ChEBI IDsCHEBI:5881, CHEBI:47498
Last Modified22 February 2017
DownloadsMolfile
FormulaC19H24N2
Net Charge0
Average Mass280.415
Monoisotopic Mass280.19395
SMILESCN(C)CCCN1c2ccccc2CCc2ccccc21
InChIInChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
InChIKeyBCGWQEUPMDMJNV-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor  Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
Applications:
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
imipramine (CHEBI:47499) has parent hydride 5H-dibenzo[b,f]azepine (CHEBI:47802)
imipramine (CHEBI:47499) has role adrenergic uptake inhibitor (CHEBI:35640)
imipramine (CHEBI:47499) has role antidepressant (CHEBI:35469)
imipramine (CHEBI:47499) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779)
imipramine (CHEBI:47499) is a dibenzoazepine (CHEBI:47804)
Incoming Relation(s)
clomipramine (CHEBI:47780) has functional parent imipramine (CHEBI:47499)
trimipramine (CHEBI:9738) has functional parent imipramine (CHEBI:47499)
imipramine hydrochloride (CHEBI:5882) has part imipramine (CHEBI:47499)
IUPAC Name 
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
INNs  Source
imipramineChemIDplus
imipraminumChemIDplus
Synonyms  Source
10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamineNIST Chemistry WebBook
3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINEPDBeChem
5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepineNIST Chemistry WebBook
N-(γ-dimethylaminopropyl)iminodibenzylNIST Chemistry WebBook
ImipraminChEBI
ImipramineKEGG COMPOUND
Brand Names  Source
AntideprinDrugBank
IrminChemIDplus
MelipramineChemIDplus
Manual XrefsDatabases
1427DrugCentral
C07049KEGG COMPOUND
D08070KEGG DRUG
DB00458DrugBank
HMDB0001848HMDB
ImipramineWikipedia
IXXPDBeChem
LSM-2852LINCS
US2554736Patent
Registry NumbersSources
Gmelin:1572523Gmelin
Beilstein:256892Beilstein
Reaxys:256892Reaxys
CAS:50-49-7NIST Chemistry WebBook
CAS:50-49-7KEGG COMPOUND
CAS:50-49-7ChemIDplus
Citations