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CHEBI:47499 - imipramine
| Formula | C19H24N2 |
| Net Charge | 0 |
| Average Mass | 280.415 |
| Monoisotopic Mass | 280.19395 |
| SMILES | CN(C)CCCN1c2ccccc2CCc2ccccc21 |
| InChI | InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 |
| InChIKey | BCGWQEUPMDMJNV-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| imipramine (CHEBI:47499) has parent hydride 5H-dibenzo[b,f]azepine (CHEBI:47802) |
| imipramine (CHEBI:47499) has role adrenergic uptake inhibitor (CHEBI:35640) |
| imipramine (CHEBI:47499) has role analgesic (CHEBI:35480) |
| imipramine (CHEBI:47499) has role antidepressant (CHEBI:35469) |
| imipramine (CHEBI:47499) has role antineoplastic agent (CHEBI:35610) |
| imipramine (CHEBI:47499) has role antipsychotic agent (CHEBI:35476) |
| imipramine (CHEBI:47499) has role anxiolytic drug (CHEBI:35474) |
| imipramine (CHEBI:47499) has role cardiovascular drug (CHEBI:35554) |
| imipramine (CHEBI:47499) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| imipramine (CHEBI:47499) is a dibenzoazepine (CHEBI:47804) |
| Incoming Relation(s) |
| clomipramine (CHEBI:47780) has functional parent imipramine (CHEBI:47499) |
| trimipramine (CHEBI:9738) has functional parent imipramine (CHEBI:47499) |
| imipramine hydrochloride (CHEBI:5882) has part imipramine (CHEBI:47499) |
| IUPAC Name |
|---|
| 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine |
| INNs | Source |
|---|---|
| imipramina | WHO MedNet |
| imipramine | ChemIDplus |
| imipraminum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine | NIST Chemistry WebBook |
| 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE | PDBeChem |
| 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine | NIST Chemistry WebBook |
| Berkomine | ChEMBL |
| Cristalia | ChEMBL |
| N-(γ-dimethylaminopropyl)iminodibenzyl | NIST Chemistry WebBook |
| Brand Names | Source |
|---|---|
| Antideprin | DrugBank |
| Irmin | ChemIDplus |
| Melipramine | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| 1427 | DrugCentral |
| C07049 | KEGG COMPOUND |
| D08070 | KEGG DRUG |
| DB00458 | DrugBank |
| HMDB0001848 | HMDB |
| Imipramine | Wikipedia |
| IXX | PDBeChem |
| LSM-2852 | LINCS |
| US2554736 | Patent |
| Citations |
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