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CHEBI:2679 - amphetamine
| ChEBI ID | CHEBI:2679 |
| ChEBI Name | amphetamine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine. |
| Secondary ChEBI ID | CHEBI:51062 |
| Last Modified | 6 June 2017 |
| Submitter | Inma Spiteri |
| Formula | C9H13N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | neurotoxin A poison that interferes with the functions of the nervous system. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. dopaminergic agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. |
| Applications: | dopamine uptake inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. dopaminergic agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. adrenergic agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes. sympathomimetic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. central nervous system stimulant Any drug that enhances the activity of the central nervous system. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| amphetamine (CHEBI:2679) has part (R)-amphetamine (CHEBI:42724) |
| amphetamine (CHEBI:2679) has part (S)-amphetamine (CHEBI:4469) |
| amphetamine (CHEBI:2679) has role adrenergic agent (CHEBI:37962) |
| amphetamine (CHEBI:2679) has role adrenergic uptake inhibitor (CHEBI:35640) |
| amphetamine (CHEBI:2679) has role bronchodilator agent (CHEBI:35523) |
| amphetamine (CHEBI:2679) has role dopamine uptake inhibitor (CHEBI:51039) |
| amphetamine (CHEBI:2679) has role dopaminergic agent (CHEBI:48560) |
| amphetamine (CHEBI:2679) has role environmental contaminant (CHEBI:78298) |
| amphetamine (CHEBI:2679) has role neurotoxin (CHEBI:50910) |
| amphetamine (CHEBI:2679) has role sympathomimetic agent (CHEBI:35524) |
| amphetamine (CHEBI:2679) has role xenobiotic (CHEBI:35703) |
| amphetamine (CHEBI:2679) is a amphetamines (CHEBI:35338) |
| amphetamine (CHEBI:2679) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine (CHEBI:64629) has functional parent amphetamine (CHEBI:2679) |
| amphetamine sulfate (CHEBI:51063) has part amphetamine (CHEBI:2679) |
| IUPAC Name |
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| rac-(2R)-1-phenylpropan-2-amine |
| INNs | Source |
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| amfetamine | WHO MedNet |
| amfetaminum | WHO MedNet |
| anfetamina | WHO MedNet |
| amfétamine | WHO MedNet |
| Synonyms | Source |
|---|---|
| Amphetamine | KEGG COMPOUND |
| α-methylbenzeneethaneamine | NIST Chemistry WebBook |
| 1-phenyl-2-aminopropane | NIST Chemistry WebBook |
| β-aminopropylbenzene | ChemIDplus |
| β-Phenylisopropylamin | ChemIDplus |
| β-phenylisopropylamine | NIST Chemistry WebBook |
| Brand Name | Source |
|---|---|
| Benzedrine | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| C07514 | KEGG COMPOUND |
| D07445 | KEGG DRUG |
| DB00182 | DrugBank |
| DB00182 | DrugBank |
| Amphetamine | Wikipedia |
| HMDB0014328 | HMDB |
| Citations |
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