Providing protein and RNA family resources
Senior Team Leader – Protein Sequence Resources
agb [at] ebi.ac.uk
ORCID: 0000-0002-6982-4660
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AntiFam is a collection of HMMs to help identify protein sequences in the databases that are likely to be false predictions.
A web-based engine for small RNA sequence analysis, quantitation and variant calling.
InterPro is used to classify proteins into families and to predict the presence of domains and functionally important site. The project integrates signatures from 13 major protein signature databases: CATH-Gene3D, CDD, HAMAP, PANTHER, Pfam, PIRSF, PRINTS, PROSITE (patterns and profiles), SFLD,…
InterProScan is a tool that provides automated functional analysis of protein and nucleic acid sequences, the latter via a full six-frame translation. It offers the ability to identify both structural and functional regions of interest, based upon methods and models that have been generated by a lar…
The MEROPS database comprises proteolytic enzymes (also termed proteases, proteinases and peptidases), their substrates and inhibitors. MEROPS uses a hierarchical, structure-based classification of proteolytic enzymes and protein inhibitors. Each peptidase or inhibitor is assigned to a Family on the…
Pfam is a database of protein sequence families. Each Pfam family is represented by a statistical model, known as a profile-hidden Markov model, which is trained using a curated alignment of representative sequences. These models can be searched against all protein sequences in order to find occurre…
Search a sequence against the Pfam HMM library
Rfam is a curated database of non-coding RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models. Our families may be divided into non-coding RNA genes, structured cis-regulatory elements and self-splicing RNAs. Rfam families are created f…
Search of Rfam’s covariance model collection
RNAcentral is a database of non-coding RNA sequences that provides a single entry point for accessing the data from an international consortium of RNA resources. RNAcentral provides a unified view of non-coding RNA sequence data and aims to represent all non-coding RNA types from all organisms
About the teamWe are seeking a skilled and highly motivated Bioinformatics Developer to join the Human Genomics Team at EMBL-EBI and contribute to the maintenance and development of the DECIPHER platform. DECIPHER is a global data sharing platform that fuels rare disease discovery and enables patien…
Closes on 9th October. Posted 17th September 2026
EditAbout the teamEMBL-EBI's HPC infrastructure underpins world-leading bioinformatics research, operating large-scale compute clusters on behalf of scientific users across the institute. The HPC sub team sits within IT and Technical Services (ITS) and is responsible for the reliability, operation, and…
Closes on 1st October. Posted 16th September 2026
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