Providing protein and RNA family resources
Senior Team Leader – Protein Sequence Resources
agb [at] ebi.ac.uk
ORCID: 0000-0002-6982-4660
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AntiFam is a collection of HMMs to help identify protein sequences in the databases that are likely to be false predictions.
A web-based engine for small RNA sequence analysis, quantitation and variant calling.
InterPro is used to classify proteins into families and to predict the presence of domains and functionally important site. The project integrates signatures from 13 major protein signature databases: CATH-Gene3D, CDD, HAMAP, PANTHER, Pfam, PIRSF, PRINTS, PROSITE (patterns and profiles), SFLD,…
InterProScan is a tool that provides automated functional analysis of protein and nucleic acid sequences, the latter via a full six-frame translation. It offers the ability to identify both structural and functional regions of interest, based upon methods and models that have been generated by a la…
The MEROPS database comprises proteolytic enzymes (also termed proteases, proteinases and peptidases), their substrates and inhibitors. MEROPS uses a hierarchical, structure-based classification of proteolytic enzymes and protein inhibitors. Each peptidase or inhibitor is assigned to a Family on th…
Pfam is a database of protein sequence families. Each Pfam family is represented by a statistical model, known as a profile-hidden Markov model, which is trained using a curated alignment of representative sequences. These models can be searched against all protein sequences in order to find occurre…
Search a sequence against the Pfam HMM library
Rfam is a curated database of non-coding RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models. Our families may be divided into non-coding RNA genes, structured cis-regulatory elements and self-splicing RNAs. Rfam families are created f…
Search of Rfam’s covariance model collection
RNAcentral is a database of non-coding RNA sequences that provides a single entry point for accessing the data from an international consortium of RNA resources. RNAcentral provides a unified view of non-coding RNA sequence data and aims to represent all non-coding RNA types from all organisms
About the TeamIn service of its world-leading life sciences services, training, and research, the Applications team within ITS operates a substantial platform based on circa 120 Kubernetes clusters, combining a large VMware on-premises estate with a growing presence in public cloud.The Platform Coor…
Closes on 13th May. Posted 14th April 2026
EditThe Ensembl Genebuild team at EMBL-EBI develops high-throughput, high-quality genome annotation pipelines that underpin our mission to provide comprehensive, open-access genomic data resources. Our work spans the eukaryotic tree of life, contributing to global biodiversity initiatives. These ambitio…
Closes on 13th May. Posted 14th April 2026
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