Reactome releases knowledgebase version 48

Updates to Reactome

This quarterly release of Reactome includes a new topic: Organelle biogenesis, which includes the pathway Mitochondrial biogenesis.

Topics with new or updated pathways include:

• Cell cycle (Depolymerisation of the nuclear lamina)
• Cellular responses to stress (Cellular responses to heat stress) 
• Development (Transcriptional regulation of pluripotent stem cells)
• Disease (Glycogen storage diseases (Myoclonic epilepsy of Lafora) and Neurotoxicity of clostridium toxins)
• Gene expression (Epigenetic regulation of gene expression)
• Metabolism of proteins (O-glycosylation of TSR domain-containing proteins and Sialic acid metabolism)
• Signal transduction (TCF-dependent signaling in response to WNT).

The Gallus gallus pathway Innate immune system has been updated to include Complement cascade. 

Acknowledgements

We thank Luciano Di Croce, Matyas Gorjanacz, Ingrid Grummt, Angela M Lezza, Juan F Medrano, Mridul Mukherji, Bibhusita Pani, Bartholomew Pederson, Gerd Pfeifer, Nishani Rajakulendran, Yih-Horng Shiao, Renee van Amerongen, Renate Voit, Jianlong Wang, and Saumya Wickramasinghe for their contributions as external reviewers.