IntAct reaches 1.5 million binary interaction evidences
IntAct 247 release is now public
The IntAct 247 release has now been made public. Together with its IMEx partner databases, IntAct now provides a total of 1,572,071 binary molecular interaction evidences curated from scientific literature.
The new IntAct release also features:
- 378,294 new binary interaction evidences from 49 publications.
- Biggest increase in the high-confidence interactions exported to UniProt, in total more than 133,600 proteins with one or more cross-references added.
- Import of Human miRNA interactome with ~17,500 mRNA-miRNA binary interactions (from 600 interactions to >18,000).
- Collaborative effort with OpenTargets on tissue-specific interactome. Check the new preprint “An atlas of protein-protein associations of human tissues prioritizes candidate disease genes” to find out more.
Featured datasets
- Dual proteome-scale networks reveal cell-specific remodeling of the human interactome (Huttlin EL et al., 2021, PubMed: 33961781).
- OpenCell: Endogenous tagging for the cartography of human cellular organization (Cho NH et al., 2022, PubMed:35271311).
- Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding (Helwak A et al., 2013, PubMed:23622248).
- The social and structural architecture of the yeast protein interactome (Michaelis AC et al., 2023, PubMed:37968396).
