Enzymes - Biotin
Biotin-using
Enzymes, which use Biotin as a cofactor
Distribution of Biotin over enzyme reaction space (E.C.)
The E.C. tree highlights the enzymes that use the cofactor on a tree of
all known E.C. numbers. Thus, it illustrates how frequently the cofactor is
used in enzyme reactions and where these reactions are located withing the
E.C. classification hierarchy.
In addition to the E.C. numbers extracted from primary literature, this graph
also incudes the E.C. numbers that have been automatically extracted from
several data resources.
E.C. tree |
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Profile of Biotin-containing reactions
The E.C. wheel is a pie chart-based representation of the enzyme
reactions this cofactor is involved in. The reactions are identified by E.C. number.
The colouring is performed by E.C. class. The figure has four levels of circles
which correspond to the four levels of the E.C. classification hierarchy. Partial
and full E.C. numbers are displayed where space suffices. Each area within the
outer two rings corresponds to one full E.C. serial number.
In addition to the E.C. numbers extracted from primary literature, this graph
also incudes the E.C. numbers that have been automatically extracted from
several data resources.
E.C. wheel |
Legend |
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Biotin-synthesising
Enzymes involved in Biotin biosynthesis
Further information
The sulphur atom of biotin is donated by an Fe/S cluster [2],[3]. Biotin is synthesised in plants and bacteria [1].
7,8-diaminopelargonic acid synthase uses PLP and SAM as cofactors (SAM as amino donor), second step of biotin biosynthesis [4].
Biotin-recycling
Enzymes involved in Biotin recycling
Biotin-binding
Enzymes binding to Biotin (mode unknown)
PROCOGNATE: proteins and cognate ligands
Protein domains that bind to this molecule
References
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