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UCH-L5 in complex with ubiquitin-propargyl bound to an activating fragment of INO80G

Source organism: Homo sapiens
Biochemical function: proteasome binding
Biological process: positive regulation of telomere maintenance in response to DNA damage
Cellular component: Ino80 complex

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EC 3.4.19.12: Ubiquitinyl hydrolase 1

Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Systematic name:
-
Alternative Name(s):
  • Ubiquitin C-terminal hydrolase
  • Ubiquitin carboxyl-terminal hydrolase
  • Ubiquitin thiolesterase
  • Yeast ubiquitin hydrolase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 4uf6 contains 4 copies of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain B.

PF18031
Domain description: Ubiquitin carboxyl-terminal hydrolases
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
The deposited structure of PDB entry 4uf6 contains 4 copies of Pfam domain PF18031 (Ubiquitin carboxyl-terminal hydrolases) in Ubiquitin carboxyl-terminal hydrolase isozyme L5. Showing 1 copy in chain D.

PF01088
Domain description: Ubiquitin carboxyl-terminal hydrolase, family 1
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
The deposited structure of PDB entry 4uf6 contains 4 copies of Pfam domain PF01088 (Ubiquitin carboxyl-terminal hydrolase, family 1) in Ubiquitin carboxyl-terminal hydrolase isozyme L5. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR001578
Domain description: Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR024867
Domain description: Nuclear factor related to kappa-B-binding protein
Occurring in:
  1. Nuclear factor related to kappa-B-binding protein
IPR044867
Domain description: DEUBAD domain
Occurring in:
  1. Nuclear factor related to kappa-B-binding protein
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR041507
Domain description: Peptidase C12, C-terminal domain
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
IPR033837
Domain description: Ubiquitinyl hydrolase-L5
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
IPR017390
Domain description: Ubiquitinyl hydrolase, UCH37 type
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5
IPR036959
Domain description: Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
Occurring in:
  1. Ubiquitin carboxyl-terminal hydrolase isozyme L5

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