Ubiquitinyl hydrolase, UCH37 type (IPR017390)

Short name: Ubiquitinyl_hydrolase_UCH37

Overlapping homologous superfamilies

Family relationships



This group represents an ubiquitin carboxyl-terminal hydrolase, UCH37 (also known as UCHL5) type.

Human UCH37 is a protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. It is also a deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome [PMID: 16906146, PMID: 18922472].

This entry also includes fission yeast Uch2, which is an ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins [PMID: 15533439].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.