Ubiquitinyl hydrolase-L5 (IPR033837)

Short name: UCH37

Overlapping homologous superfamilies

Domain relationships


The ubiquitin C-terminal hydrolase (UCH; ubiquitinyl hydrolase; ubiquitin thiolesterase; MEROPS family C12) family of deubiquitinating enzymes (DUBs) consists of several members including: UCH-L1, UCH-L3, UCH-L5 (UCH37) and BRCA1-associated protein-1 (BAP1), all containing a conserved catalytic domain with cysteine peptidase activity [PMID: 20302916].

UCH-L5 (UCH37; MEROPS identifier C12.005) is involved in the deubiquitinating activity in the 19S proteasome regulatory complex. It is also associated with the human Ino80 chromatin-remodeling complex (hINO80) in the nucleus [PMID: 18922472]. UCH-L5 specifically cleaves 'Lys-48'-linked polyubiquitin chains [PMID: 19836345].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0070628 proteasome binding
GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

GO:0031011 Ino80 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.