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Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1

X-ray diffraction
2.6Å resolution
PDB entry 3bji coloured by chain, front view.
PDB entry 3bji coloured by chain, side view.
PDB entry 3bji coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ras-related C3 botulinum toxin substrate 1 and Proto-oncogene vav
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Multimeric state: hetero dimer
Accessible surface area: 25361.01 Å2
Buried surface area: 2428.09 Å2
Dissociation area: 1,214.05 Å2
Dissociation energy (ΔGdiss): 8.49 kcal/mol
Dissociation entropy (TΔSdiss): 12.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147391
Assembly 2
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Assembly Name: Ras-related C3 botulinum toxin substrate 1 and Proto-oncogene vav
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Multimeric state: hetero dimer
Accessible surface area: 25463.29 Å2
Buried surface area: 2589.5 Å2
Dissociation area: 1,294.75 Å2
Dissociation energy (ΔGdiss): 6.26 kcal/mol
Dissociation entropy (TΔSdiss): 12.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147391

Macromolecules

Proto-oncogene vav
Chains: A, B
Length: 378 amino acids
Theoretical weight: 44.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P15498 (Residues: 189-565; Coverage: 45%)
Gene names: VAV, VAV1
Pfam:
InterPro:
CATH:
Proto-oncogene vav in PDB entry 3bji, assembly 1, front view.
Proto-oncogene vav in PDB entry 3bji, assembly 1, side view.
Proto-oncogene vav in PDB entry 3bji, assembly 1, top view.
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Ras-related C3 botulinum toxin substrate 1
Chains: C, D
Length: 177 amino acids
Theoretical weight: 19.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63000 (Residues: 1-177; Coverage: 92%)
Gene names: MIG5, RAC1, TC25
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Ras-related C3 botulinum toxin substrate 1 in PDB entry 3bji, assembly 1, front view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 3bji, assembly 1, side view.
Ras-related C3 botulinum toxin substrate 1 in PDB entry 3bji, assembly 1, top view.
Molecule details ›

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