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Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1

Source organism: Homo sapiens
Biochemical function: Rho GDP-dissociation inhibitor binding
Biological process: intracellular signal transduction
Cellular component: ficolin-1-rich granule membrane

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EC 3.6.5.2: Small monomeric GTPase

Reaction catalysed:
GTP + H(2)O = GDP + phosphate
Systematic name:
GTP phosphohydrolase (cell-regulating)

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00071
Domain description: Ras family
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 3bji contains 2 copies of Pfam domain PF00071 (Ras family) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain C.

PF00130
Domain description: Phorbol esters/diacylglycerol binding domain (C1 domain)
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of Pfam domain PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) in Proto-oncogene vav. Showing 1 copy in chain A.

PF00169
Domain description: PH domain
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of Pfam domain PF00169 (PH domain) in Proto-oncogene vav. Showing 1 copy in chain A.

PF00621
Domain description: RhoGEF domain
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of Pfam domain PF00621 (RhoGEF domain) in Proto-oncogene vav. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000219
Domain description: Dbl homology (DH) domain
Occurring in:
  1. Proto-oncogene vav
IPR001806
Domain description: Small GTPase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Proto-oncogene vav
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR002219
Domain description: Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Occurring in:
  1. Proto-oncogene vav
IPR035899
Domain description: Dbl homology (DH) domain superfamily
Occurring in:
  1. Proto-oncogene vav
IPR003578
Domain description: Small GTPase Rho
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
IPR037832
Domain description: Vav, PH domain
Occurring in:
  1. Proto-oncogene vav
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Proto-oncogene vav
IPR001331
Domain description: Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Occurring in:
  1. Proto-oncogene vav

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 3bji contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain C.
3.30.60.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of CATH domain 3.30.60.20 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Proto-oncogene vav. Showing 1 copy in chain A.
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Proto-oncogene vav. Showing 1 copy in chain A.
1.20.900.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Dbl Homology Domain; Chain A
Homology: Dbl homology (DH) domain
Occurring in:
  1. Proto-oncogene vav
The deposited structure of PDB entry 3bji contains 2 copies of CATH domain 1.20.900.10 (Dbl Homology Domain; Chain A) in Proto-oncogene vav. Showing 1 copy in chain A.
SCOP SCOP annotation
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Ras-related C3 botulinum toxin substrate 1
The deposited structure of PDB entry 3bji contains 2 copies of SCOP domain 52592 (G proteins) in Ras-related C3 botulinum toxin substrate 1. Showing 1 copy in chain C.

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