Homologous Superfamily

PH-like domain superfamily (IPR011993)

Short name: PH-like_dom_sf


Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [PMID: 14594214, PMID: 12694559, PMID: 21119626].

PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1), Shc adaptor and Numb; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein; to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin; and to the PH-like domain of neurobeachin.

This superfamily represents PH domains and other structurally related domains.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.