PH domain-like (IPR011993)
Short name: PH_dom-like
- PH domain-like (IPR011993)
- Bacterial Pleckstrin homology domain (IPR012544)
- FERM, C-terminal PH-like domain (IPR018980)
- IRS-type PTB domain (IPR002404)
- NECAP-1, N-terminal (IPR012466)
- PTB/PI domain (IPR006020)
- Pleckstrin homology domain (IPR001849)
- Ran binding domain (IPR000156)
- TFIIH p62 subunit, N-terminal (IPR013876)
- WH1/EVH1 domain (IPR000697)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of signalling proteins, where they serve as simple targeting domains that bind lipids [PMID: 14594214, PMID: 12694559, PMID: 21119626].
PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1), Shc adaptor and Numb; to the Ran-binding domain, found in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain), found in Enabled, VASP (vasodilator-stimulated phosphoprotein), Homer and WASP actin regulatory protein; to the third domain of FERM, found in moesin, radixin, ezrin, merlin and talin; and to the PH-like domain of neurobeachin.
This entry recognises PH domains and other structurally related domains.