› › Structure analysis

Structure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex

X-ray diffraction
2.65Å resolution
PDB entry 2wtk coloured by chain, front view.
PDB entry 2wtk coloured by chain, side view.
PDB entry 2wtk coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: LKB1-STRAD-MO25 serine/threonine protein kinase complex, CAB39-STRADA variant
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 40436.89 Å2
Buried surface area: 8157.51 Å2
Dissociation area: 2,506.01 Å2
Dissociation energy (ΔGdiss): 18.02 kcal/mol
Dissociation entropy (TΔSdiss): 14.72 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172423
Complex Portal ID: CPX-2845
Assembly 2
Download    3D Visualisation
Assembly Name: LKB1-STRAD-MO25 serine/threonine protein kinase complex, CAB39-STRADA variant
hide full assembly name
Multimeric state: hetero trimer
Accessible surface area: 41077.96 Å2
Buried surface area: 7867.16 Å2
Dissociation area: 1,652.89 Å2
Dissociation energy (ΔGdiss): 11.28 kcal/mol
Dissociation entropy (TΔSdiss): 14.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172423
Complex Portal ID: CPX-2845

Macromolecules

Calcium-binding protein 39
Chains: A, D
Length: 341 amino acids
Theoretical weight: 39.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9Y376 (Residues: 1-341; Coverage: 100%)
Gene names: CAB39, CGI-66, MO25
Pfam: Mo25-like
InterPro:
CATH: Leucine-rich Repeat Variant
Calcium-binding protein 39 in PDB entry 2wtk, assembly 1, front view.
Calcium-binding protein 39 in PDB entry 2wtk, assembly 1, side view.
Calcium-binding protein 39 in PDB entry 2wtk, assembly 1, top view.
Molecule details ›

Search similar proteins

STE20-related kinase adapter protein alpha
Chains: B, E
Length: 373 amino acids
Theoretical weight: 41.75 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q7RTN6 (Residues: 59-431; Coverage: 87%)
Gene names: LYK5, STRAD, STRADA
Pfam: Protein kinase domain
InterPro:
CATH:
STE20-related kinase adapter protein alpha in PDB entry 2wtk, assembly 1, front view.
STE20-related kinase adapter protein alpha in PDB entry 2wtk, assembly 1, side view.
STE20-related kinase adapter protein alpha in PDB entry 2wtk, assembly 1, top view.
Molecule details ›

Search similar proteins

Serine/threonine-protein kinase STK11
Chains: C, F
Length: 305 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15831 (Residues: 43-347; Coverage: 70%)
Gene names: LKB1, PJS, STK11
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase STK11 in PDB entry 2wtk, assembly 1, front view.
Serine/threonine-protein kinase STK11 in PDB entry 2wtk, assembly 1, side view.
Serine/threonine-protein kinase STK11 in PDB entry 2wtk, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links