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The Thrombospondin-1 Polymorphism Asn700Ser Associated with Cornoary Artery Disease Causes Local and Long-Ranging Changes in Protein Structure

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: cell adhesion
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF02412
Domain description: Thrombospondin type 3 repeat
Occurring in:
  1. Thrombospondin-2
The deposited structure of PDB entry 2rhp contains 7 copies of Pfam domain PF02412 (Thrombospondin type 3 repeat) in Thrombospondin-2. Showing 7 copies in chain A.

PF05735
Domain description: Thrombospondin C-terminal region
Occurring in:
  1. Thrombospondin-2
The deposited structure of PDB entry 2rhp contains 1 copy of Pfam domain PF05735 (Thrombospondin C-terminal region) in Thrombospondin-2. Showing 1 copy in chain A.

PF12947
Domain description: EGF domain
Occurring in:
  1. Thrombospondin-2
The deposited structure of PDB entry 2rhp contains 1 copy of Pfam domain PF12947 (EGF domain) in Thrombospondin-2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003367
Domain description: Thrombospondin, type 3-like repeat
Occurring in:
  1. Thrombospondin-2
IPR028974
Domain description: TSP type-3 repeat
Occurring in:
  1. Thrombospondin-2
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Thrombospondin-2
IPR017897
Domain description: Thrombospondin, type 3 repeat
Occurring in:
  1. Thrombospondin-2
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Thrombospondin-2
IPR008859
Domain description: Thrombospondin, C-terminal
Occurring in:
  1. Thrombospondin-2
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Thrombospondin-2
IPR024731
Domain description: EGF domain
Occurring in:
  1. Thrombospondin-2

Structure domains

CATH CATH domains
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Thrombospondin-2
The deposited structure of PDB entry 2rhp contains 3 copies of CATH domain 2.10.25.10 (Laminin) in Thrombospondin-2. Showing 3 copies in chain A.
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Thrombospondin-2
The deposited structure of PDB entry 2rhp contains 1 copy of CATH domain 2.60.120.200 (Jelly Rolls) in Thrombospondin-2. Showing 1 copy in chain A.

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