Homologous Superfamily

TSP type-3 repeat (IPR028974)

Short name: TSP_type-3_rpt

Overlapping entries


This entry represents the calcium-binding type 3 (T3) repeats found in extracellular calcium-binding multifunctional proteins, thrombospondins (TSPs). The T3 repeats lack secondary structure and are organised around a core of calcium ions; two DxDxDGxxDxxD motifs per repeat each encapsulate two calcium ions in a novel arrangement [PMID: 15014436].

TSP type-3 repeat can be found in the following proteins:

  • Cartilage oligomeric matrix protein: may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin [PMID: 16051604].
  • Outer membrane porin F from bacteria [PMID: 23056489].
  • Alpha-agarase: hydrolyses agarose, agarohexaose, neoagarohexaose and porphyran [PMID: 17177517, PMID: 17513582].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.