Pathways & interactions
Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Short name: ConA-like_subgrp
- Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
- Alginate lyase 2 (IPR014895)
- Alpha-L-arabinofuranosidase B, catalytic (IPR015289)
- Clostridium neurotoxin, receptor binding N-terminal (IPR012928)
- Galectin, carbohydrate recognition domain (IPR001079)
- Glycoside hydrolase, family 16 (IPR000757)
Lectins and glucanases exhibit the common property of reversibly binding to specific complex carbohydrates. The lectins/glucanases are a diverse group of proteins found in a wide range of species from prokaryotes to humans. The different family members all contain a concanavalin A-like domain, which consists of a sandwich of 12-14 beta strands in two sheets with a complex topology. Members of this family are diverse, and include the lectins: legume lectins, cereal lectins, viral lectins, and animal lectins. Plant lectins function in the storage and transport of carbohydrates in seeds, the binding of nitrogen-fixing bacteria to root hairs, the inhibition of fungal growth or insect feeding, and in hormonally regulated plant growth [PMID: 9094437]. Protein members include concanavalin A (Con A), favin, isolectin I, lectin IV, soybean agglutinin and lentil lectin. Animal lectins include the galectins, which are S-type lactose-binding and IgE-binding proteins such as S-lectin, CLC protein, galectin1, galectin2, galectin3 CRD, and Congerin I [PMID: 11834744].
Other members with a Con A-like domain include the glucanases. Bacterial and fungal beta-glucanases, such as Bacillus 1-3,1-4-beta-glucanse, carry out the acid catalysis of beta-glucans found in microorganisms and plants [PMID: 7589539]. Similarly, kappa-Carrageenase degrades kappa-carrageenans from marine red algae cell walls [PMID: 11435116].
- G3DSA:22.214.171.124 (G3DSA:126.96.36.199)