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THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA

X-ray diffraction
2.2Å resolution
PDB entry 2fap coloured by chain, front view.
PDB entry 2fap coloured by chain, side view.
PDB entry 2fap coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase mTOR and Peptidyl-prolyl cis-trans isomerase FKBP1A
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Multimeric state: hetero dimer
Accessible surface area: 10806.65 Å2
Buried surface area: 2267.29 Å2
Dissociation area: 738.25 Å2
Dissociation energy (ΔGdiss): -2.1 kcal/mol
Dissociation entropy (TΔSdiss): 10.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154618

Macromolecules

Peptidyl-prolyl cis-trans isomerase FKBP1A
Chain: A
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Pfam: FKBP-type peptidyl-prolyl cis-trans isomerase
InterPro:
CATH: Chitinase A; domain 3
SCOP: FKBP immunophilin/proline isomerase
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 2fap, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 2fap, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 2fap, assembly 1, top view.
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Serine/threonine-protein kinase mTOR
Chain: B
Length: 94 amino acids
Theoretical weight: 11.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42345 (Residues: 2019-2112; Coverage: 4%)
Gene names: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Pfam: FKBP12-rapamycin binding domain
InterPro:
CATH: FKBP12-rapamycin binding domain
SCOP: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
Serine/threonine-protein kinase mTOR in PDB entry 2fap, assembly 1, front view.
Serine/threonine-protein kinase mTOR in PDB entry 2fap, assembly 1, side view.
Serine/threonine-protein kinase mTOR in PDB entry 2fap, assembly 1, top view.
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