Homologous Superfamily

FKBP12-rapamycin binding domain superfamily (IPR036738)

Short name: FRB_sf

Overlapping entries


The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins.

This superfamily represents the FRB domain [PMID: 8662507, PMID: 26700129]. Proteins containing this domain include Tor proteins which are serine/threonine kinases conserved from fungi to humans. While higher eukaryotes such as humans possess a single Tor protein, yeasts contain two (Tor1 and Tor2) [PMID: 26028537].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0044877 protein-containing complex binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.