Domain

FKBP-type peptidyl-prolyl cis-trans isomerase domain (IPR001179)

Short name: PPIase_FKBP_dom

Domain relationships

None.

Description

This entry represents a domain found in FKBP-type peptidylprolyl isomerases.

FKBP-type peptidylprolyl isomerases (EC:5.2.1.8) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam