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Pyruvate oxidase variant F479W

Source organism: Lactiplantibacillus plantarum
Biochemical function: pyruvate oxidase activity
Biological process: not assigned
Cellular component: not assigned

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EC 1.2.3.3: Pyruvate oxidase

Reaction catalysed:
Pyruvate + phosphate + O(2) = acetyl phosphate + CO(2) + H(2)O(2)
Systematic name:
Pyruvate:oxygen 2-oxidoreductase (phosphorylating)
Alternative Name(s):
  • Phosphate-dependent pyruvate oxidase
  • Pyruvic oxidase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02775
Domain description: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of Pfam domain PF02775 (Thiamine pyrophosphate enzyme, C-terminal TPP binding domain) in Pyruvate oxidase. Showing 1 copy in chain A.

PF00205
Domain description: Thiamine pyrophosphate enzyme, central domain
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of Pfam domain PF00205 (Thiamine pyrophosphate enzyme, central domain) in Pyruvate oxidase. Showing 1 copy in chain A.

PF02776
Domain description: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of Pfam domain PF02776 (Thiamine pyrophosphate enzyme, N-terminal TPP binding domain) in Pyruvate oxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029061
Domain description: Thiamin diphosphate-binding fold
Occurring in:
  1. Pyruvate oxidase
IPR000399
Domain description: TPP-binding enzyme, conserved site
Occurring in:
  1. Pyruvate oxidase
IPR011766
Domain description: Thiamine pyrophosphate enzyme, TPP-binding
Occurring in:
  1. Pyruvate oxidase
IPR047212
Domain description: Pyruvate oxidase POXB-like, PP-binding domain
Occurring in:
  1. Pyruvate oxidase
IPR012000
Domain description: Thiamine pyrophosphate enzyme, central domain
Occurring in:
  1. Pyruvate oxidase
IPR029035
Domain description: DHS-like NAD/FAD-binding domain superfamily
Occurring in:
  1. Pyruvate oxidase
IPR012001
Domain description: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
Occurring in:
  1. Pyruvate oxidase
IPR047211
Domain description: Pyruvate oxidase/Pyruvate dehydrogenase [ubiquinone]-like
Occurring in:
  1. Pyruvate oxidase
IPR047210
Domain description: Pyruvate oxidase POXB-like, pyrimidine-binding domain
Occurring in:
  1. Pyruvate oxidase
IPR014092
Domain description: Pyruvate oxidase
Occurring in:
  1. Pyruvate oxidase

Structure domains

CATH CATH domains
3.40.50.970
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 4 copies of CATH domain 3.40.50.970 (Rossmann fold) in Pyruvate oxidase. Showing 2 copies in chain A.
3.40.50.1220
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: TPP-binding domain
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of CATH domain 3.40.50.1220 (Rossmann fold) in Pyruvate oxidase. Showing 1 copy in chain A.
SCOP SCOP annotations
88749
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of SCOP domain 88749 (Pyruvate oxidase and decarboxylase PP module) in Pyruvate oxidase. Showing 1 copy in chain A.
52475
Class: Alpha and beta proteins (a/b)
Fold: DHS-like NAD/FAD-binding domain
Superfamily: DHS-like NAD/FAD-binding domain
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of SCOP domain 52475 (Pyruvate oxidase and decarboxylase, middle domain) in Pyruvate oxidase. Showing 1 copy in chain A.
88724
Class: Alpha and beta proteins (a/b)
Fold: Thiamin diphosphate-binding fold (THDP-binding)
Superfamily: Thiamin diphosphate-binding fold (THDP-binding)
Occurring in:
  1. Pyruvate oxidase
The deposited structure of PDB entry 2ez4 contains 2 copies of SCOP domain 88724 (Pyruvate oxidase and decarboxylase Pyr module) in Pyruvate oxidase. Showing 1 copy in chain A.

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