Domain

Thiamin diphosphate-binding fold (IPR029061)

Short name: THDP-binding

Domain relationships

None.

Description

This entry represents the thiamin diphosphate-binding fold found in pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases [PMID: 8069629]. There are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules. Two Pyr and two PP modules can assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY