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STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

X-ray diffraction
2.9Å resolution
PDB entry 1g3n coloured by chain, front view.
PDB entry 1g3n coloured by chain, side view.
PDB entry 1g3n coloured by chain, top view.
Source organisms:
Assemblies composition:
hetero trimer (preferred)
hetero tetramer
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 29396.12 Å2
Buried surface area: 4148.89 Å2
Dissociation area: 889.36 Å2
Dissociation energy (ΔGdiss): -0.44 kcal/mol
Dissociation entropy (TΔSdiss): 12.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154869
Assembly 2
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Multimeric state: hetero trimer
Accessible surface area: 29473.15 Å2
Buried surface area: 4148.93 Å2
Dissociation area: 876.31 Å2
Dissociation energy (ΔGdiss): -0.28 kcal/mol
Dissociation entropy (TΔSdiss): 12.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-154869
Assembly 3
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Assembly Name: Cyclin-dependent kinase 6 and Cyclin-like domain-containing protein
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Multimeric state: hetero tetramer
Accessible surface area: 44563.97 Å2
Buried surface area: 7651.11 Å2
Dissociation area: 1,442.31 Å2
Dissociation energy (ΔGdiss): 2.53 kcal/mol
Dissociation entropy (TΔSdiss): 15.15 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-219584
Assembly 4
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Assembly Name: Cyclin-dependent kinase 4 inhibitor C and Cyclin-dependent kinase 6
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Multimeric state: hetero tetramer
Accessible surface area: 39047.83 Å2
Buried surface area: 5854.37 Å2
Dissociation area: 1,765.67 Å2
Dissociation energy (ΔGdiss): -0.88 kcal/mol
Dissociation entropy (TΔSdiss): 25.52 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154871

Macromolecules

Cyclin-dependent kinase 6
Chains: A, E
Length: 326 amino acids
Theoretical weight: 36.99 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q00534 (Residues: 1-326; Coverage: 100%)
Gene names: CDK6, CDKN6
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Cyclin-dependent kinase 6 in PDB entry 1g3n, assembly 1, front view.
Cyclin-dependent kinase 6 in PDB entry 1g3n, assembly 1, side view.
Cyclin-dependent kinase 6 in PDB entry 1g3n, assembly 1, top view.
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Cyclin-dependent kinase 4 inhibitor C
Chains: B, F
Length: 168 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42773 (Residues: 1-168; Coverage: 100%)
Gene names: CDKN2C, CDKN6
Pfam: Ankyrin repeats (3 copies)
InterPro:
CATH: Ankyrin repeat-containing domain
SCOP: Ankyrin repeat
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1g3n, assembly 1, front view.
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1g3n, assembly 1, side view.
Cyclin-dependent kinase 4 inhibitor C in PDB entry 1g3n, assembly 1, top view.
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Cyclin-like domain-containing protein
Chains: C, G
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q98147 (Residues: 1-257; Coverage: 100%)
Pfam:
InterPro:
CATH: Cyclin-like
SCOP: Cyclin
Cyclin-like domain-containing protein in PDB entry 1g3n, assembly 1, front view.
Cyclin-like domain-containing protein in PDB entry 1g3n, assembly 1, side view.
Cyclin-like domain-containing protein in PDB entry 1g3n, assembly 1, top view.
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