PDBe 1g3n

X-ray diffraction
2.9Å resolution

STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero tetramer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Kaposi's sarcoma-associated herpesvirus cyclin homolog Chains: C, G
Molecule details ›
Chains: C, G
Length: 257 amino acids
Theoretical weight: 28.09 KDa
Source organism: Human gammaherpesvirus 8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q98147 (Residues: 1-257; Coverage: 100%)
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 6 Chains: A, E
Molecule details ›
Chains: A, E
Length: 326 amino acids
Theoretical weight: 36.99 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q00534 (Residues: 1-326; Coverage: 100%)
Gene names: CDK6, CDKN6
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-dependent kinase 4 inhibitor C Chains: B, F
Molecule details ›
Chains: B, F
Length: 168 amino acids
Theoretical weight: 18.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42773 (Residues: 1-168; Coverage: 100%)
Gene names: CDKN2C, CDKN6
Sequence domains: Ankyrin repeats (many copies)
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200H
Spacegroup: P212121
Unit cell:
a: 77.78Å b: 146.95Å c: 164.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.224 0.262
Expression systems:
  • Escherichia coli
  • unidentified baculovirus