Family

Cyclin-dependent kinase 6 (IPR028788)

Short name: CDK6

Family relationships

None.

Description

Cyclin-dependent kinase 6 (CDK6) is a D-Cyclin-activated kinase that is involved in driving the cell cycle through inactivation of pRB in G1 phase [PMID: 8114739, PMID: 24196439]. It has been implicated in cell proliferation [PMID: 14985467] and tumor angiogenesis [PMID: 23948297]. It is also involved in cell differentiation through regulation of gene expression [PMID: 15254224]. CDK6 interacts with the p65 subunit of NFkB in the nucleus, and is found at promoters of many transcriptionally active NFkB target genes [PMID: 24389100].

GO terms

Biological Process

GO:0007049 cell cycle
GO:0043697 cell dedifferentiation
GO:0042127 regulation of cell proliferation

Molecular Function

GO:0004693 cyclin-dependent protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD