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HUMAN BETA-GLUCURONIDASE AT 2.6 A RESOLUTION

Source organism: Homo sapiens
Biochemical function: hydrolase activity, hydrolyzing O-glycosyl compounds
Biological process: carbohydrate metabolic process
Cellular component: not assigned

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EC 3.2.1.31: Beta-glucuronidase

Reaction catalysed:
A beta-D-glucuronoside + H(2)O = D-glucuronate + an alcohol
Systematic name:
Beta-D-glucuronoside glucuronosohydrolase
Alternative Name(s):
  • Beta-glucuronide glucuronohydrolase
  • Exo-beta-D-glucuronidase
  • Glucuronidase
  • Ketodase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02836
Domain description: Glycosyl hydrolases family 2, TIM barrel domain
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of Pfam domain PF02836 (Glycosyl hydrolases family 2, TIM barrel domain) in Beta-glucuronidase. Showing 1 copy in chain A.

PF00703
Domain description: Glycosyl hydrolases family 2
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of Pfam domain PF00703 (Glycosyl hydrolases family 2) in Beta-glucuronidase. Showing 1 copy in chain A.

PF02837
Domain description: Glycosyl hydrolases family 2, sugar binding domain
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of Pfam domain PF02837 (Glycosyl hydrolases family 2, sugar binding domain) in Beta-glucuronidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006101
Domain description: Glycoside hydrolase, family 2
Occurring in:
  1. Beta-glucuronidase
IPR023232
Domain description: Glycoside hydrolase, family 2, active site
Occurring in:
  1. Beta-glucuronidase
IPR023230
Domain description: Glycoside hydrolase, family 2, conserved site
Occurring in:
  1. Beta-glucuronidase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Beta-glucuronidase
IPR006103
Domain description: Glycoside hydrolase family 2, catalytic domain
Occurring in:
  1. Beta-glucuronidase
IPR036156
Domain description: Beta-Galactosidase/glucuronidase domain superfamily
Occurring in:
  1. Beta-glucuronidase
IPR006102
Domain description: Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
Occurring in:
  1. Beta-glucuronidase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Beta-glucuronidase
IPR006104
Domain description: Glycosyl hydrolases family 2, sugar binding domain
Occurring in:
  1. Beta-glucuronidase
IPR008979
Domain description: Galactose-binding-like domain superfamily
Occurring in:
  1. Beta-glucuronidase

Structure domains

CATH CATH domains
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of CATH domain 3.20.20.80 (TIM Barrel) in Beta-glucuronidase. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-glucuronidase. Showing 1 copy in chain A.
2.60.120.260
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Galactose-binding domain-like
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of CATH domain 2.60.120.260 (Jelly Rolls) in Beta-glucuronidase. Showing 1 copy in chain A.
SCOP SCOP annotations
51487
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of SCOP domain 51487 (beta-glycanases) in Beta-glucuronidase. Showing 1 copy in chain A.
49304
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: beta-Galactosidase/glucuronidase domain
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of SCOP domain 49304 (beta-Galactosidase/glucuronidase domain) in Beta-glucuronidase. Showing 1 copy in chain A.
49803
Class: All beta proteins
Fold: Galactose-binding domain-like
Superfamily: Galactose-binding domain-like
Occurring in:
  1. Beta-glucuronidase
The deposited structure of PDB entry 1bhg contains 2 copies of SCOP domain 49803 (beta-Galactosidase/glucuronidase, N-terminal domain) in Beta-glucuronidase. Showing 1 copy in chain A.

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