Domain

Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich (IPR006102)

Short name: Glyco_hydro_2_Ig-like

Domain relationships

Description

O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 2 GH2 comprises enzymes with several known activities: beta-galactosidase (EC:3.2.1.23); beta-mannosidase (EC:3.2.1.25); beta-glucuronidase (EC:3.2.1.31).

These enzymes contain a conserved glutamic acid residue which has been shown [PMID: 1350782], in Escherichia coli lacZ (P00722), to be the general acid/base catalyst in the active site of the enzyme.

This entry describes the immunoglobulin-like beta-sandwich domain [PMID: 8008071].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SUPERFAMILY