EMD-0190

Single-particle
3.09 Å
EMD-0190
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Deposition: 13/08/2018
Map released: 07/11/2018
Last modified: 23/10/2019
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-0190
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3D volume (map.gz) Experimental metadata (xml)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 6hbu summary report (pdf.gz) Map and 6hbu FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and Magnesium

EMD-0190

Single-particle
3.09 Å
EMD-0190
3D View Gallery
Deposition: 13/08/2018
Map released: 07/11/2018
Last modified: 23/10/2019
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Name: inhibitor-bound ABCG2
Complex [2]
Name: inhibitor-bound ABCG2
Complex Portal [3]
ID Name Overlap
CPX-22033 - 0.50
CPX-22704 - 0.50
CPX-15509 - 0.50
Name: A mutant (E211Q) of the ATP-binding cassette sub-family G member 2
Natural source [1]
Organism: HOMO SAPIENS
Recombinant Expression [1]
Organism Strain Cell Plasmid
HOMO SAPIENS - - -
Complex Portal [3]
ID Name Overlap
CPX-22704 - 0.50
CPX-22033 - 0.50
CPX-15509 - 0.50
Protein [1]
LEVO
Name: ATP-binding cassette sub-family G member 2
Number of copies: 2
UniProtKB PDBe-KB AlphaFold DB
Domains
Gene Ontology [36]
Biological process:
sphingolipid biosynthetic process cellular detoxification lipid transport transmembrane transport transepithelial transport transport across blood-brain barrier urate salt excretion xenobiotic transport across blood-brain barrier riboflavin transport export across plasma membrane biotin transport organic anion transport urate metabolic process renal urate salt excretion
Molecular function:
sphingolipid transporter activity ATP hydrolysis activity urate transmembrane transporter activity xenobiotic transmembrane transporter activity riboflavin transmembrane transporter activity biotin transmembrane transporter activity organic anion transmembrane transporter activity identical protein binding protein homodimerization activity ATPase-coupled transmembrane transporter activity ATP binding ABC-type xenobiotic transporter activity efflux transmembrane transporter activity
Cellular location:
membrane plasma membrane nucleoplasm external side of apical plasma membrane brush border membrane integral component of membrane apical plasma membrane mitochondrial membrane membrane raft
Natural source
Organism: Homo sapiens
Molecular weight
Experimental Theoretical Method
- 72 kDa -
Recombinant Expression
Organism Strain Cell Plasmid
Homo sapiens - - -
Ligand [2]
Name: ADENOSINE-5'-TRIPHOSPHATE
HET code: ATP
Number of copies: 2
ChEMBL ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 507 Da -
Name: MAGNESIUM ION
HET code: MG
Number of copies: 2
ChEBI DrugBank
Molecular weight
Experimental Theoretical Method
- 24 Da -