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Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ DOI: doi:10.1038/s41421-022-00477-0 Pubmed: 36280665 ]
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Trh peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Antibody (Complex from synthetic construct)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ DOI: doi:10.1038/s41467-022-34696-6 Pubmed: 36396650 ]
- Gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ DOI: doi:10.1038/s41467-022-34696-6 Pubmed: 36396650 ]
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ha0
Q-score: 0.485
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol.Sin. (2023) 44 pp. 1227-1237 [ Pubmed: 36482086 DOI: doi:10.1038/s41401-022-01032-z ]
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Pth-pthr g protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
human KCNQ1-CaM in complex with ML277
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7xnk
Q-score: 0.467
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- Kcnq1-cam in complex with ml277 (Cellular component from Homo sapiens)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
human KCNQ1-CaM-ML277-PIP2 complex in state B
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7xnn
Q-score: 0.428
Ma D, Zhong L, Yan Z, Yao J, Zhang Y, Ye F, Huang Y, Lai D, Yang W, Hou P, Guo J
PNAS (2022) 119 pp. e2207067119-e2207067119 [ Pubmed: 36763058 DOI: doi:10.1073/pnas.2207067119 ]
- Human kcnq1-cam-ml277-pip2 complex in state b (Cellular component from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 1 (76 kDa, Protein from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-3 (19 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- (2r)-n-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide (471 Da, Ligand)
CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7t2g
Q-score: 0.672
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G
Nat Chem Biol (2022) [ Pubmed: 36411392 DOI: doi:10.1038/s41589-022-01208-y ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mu-opioid receptor / gi protein complex bound to mitragynine pseudoindoxyl (mp). (Complex from Mus musculus)
- Soluble cytochrome b562,mu-type opioid receptor (55 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mitragynine pseudoindoxyl (414 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8e9w
Q-score: 0.543
Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL
Nature (2022) 612 pp. 354-362 [ Pubmed: 36450989 DOI: doi:10.1038/s41586-022-05489-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Minigq (28 kDa, Protein from Homo sapiens)
- Muscarinic acetylcholine receptor m3 (41 kDa, Protein from Homo sapiens)
- Gq-coupled hm3r complex (Complex)
- 11-(4-methylpiperazin-1-yl)-5h-dibenzo[b,e][1,4]diazepine (292 Da, Ligand)
- Muscarinic acetylcholine receptor 3, minigq protein, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
CryoEM structure of miniGo-coupled hM4Di in complex with DCZ
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8e9x
Q-score: 0.547
Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL
Nature (2022) 612 pp. 354-362 [ Pubmed: 36450989 DOI: doi:10.1038/s41586-022-05489-0 ]
- Scfv16 (26 kDa, Protein from Mus musculus)
- Muscarinic acetylcholine receptor 4, minigo protein, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Minigo (25 kDa, Protein from Homo sapiens)
- Gq-coupled hm3r complex (Complex)
- 11-(4-methylpiperazin-1-yl)-5h-dibenzo[b,e][1,4]diazepine (292 Da, Ligand)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
CryoEM structure of miniGq-coupled hM3Dq in complex with CNO
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8e9y
Q-score: 0.482
Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL
Nature (2022) 612 pp. 354-362 [ Pubmed: 36450989 DOI: doi:10.1038/s41586-022-05489-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 8-chloro-11-(4-methyl-4-oxo-4lambda~5~-piperazin-1-yl)-5h-dibenzo[b,e][1,4]diazepine (342 Da, Ligand)
- Muscarinic acetylcholine receptor 3, minigq protein, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Minigq (28 kDa, Protein from Homo sapiens)
- Gq-coupled hm3r complex (Complex)
- Single-chain variable fragment scfv16 (Complex from Mus musculus)
- Muscarinic acetylcholine receptor m3 (62 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)