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CryoEM structure of Gi-coupled TAS2R14 with cholesterol and an intracellular tastant
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8vy7
Q-score: 0.52
Kim Y, Gumpper RH, Liu Y, Kocak DD, Xiong Y, Cao C, Deng Z, Krumm BE, Jain MK, Zhang S, Jin J, Roth BL
Nature (2024) 628 pp. 664-671 [ DOI: doi:10.1038/s41586-024-07253-y Pubmed: 38600377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 4-methyl-n-[(2m)-2-(1h-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (321 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Ternary complex of tas2r14 with gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Taste receptor type 2 member 14 (70 kDa, Protein from Homo sapiens)
CryoEM structure of Ggust-coupled TAS2R14 with cholesterol and an intracellular tastant
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8vy9
Q-score: 0.479
Kim Y, Gumpper RH, Liu Y, Kocak DD, Xiong Y, Cao C, Deng Z, Krumm BE, Jain MK, Zhang S, Jin J, Roth BL
Nature (2024) 628 pp. 664-671 [ DOI: doi:10.1038/s41586-024-07253-y Pubmed: 38600377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Taste receptor type 2 member 14,gpcr,taste receptor type 2 member 14 (72 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(t) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Ternary complex of tas2r14 with ggust heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- 4-methyl-n-[(2m)-2-(1h-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)pyrimidin-2-amine (321 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8i7v
Q-score: 0.495
Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY
Nat Commun (2023) 14 pp. 7150-7150 [ Pubmed: 37932263 DOI: doi:10.1038/s41467-023-42764-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Human hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2,hydroxycarboxylic acid receptor 2 (54 kDa, Protein from Homo sapiens)
- Acipomox bound human hydroxy-carboxylic acid receptor 2 in complex with gi heterotrimer (150 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jbg
Q-score: 0.569
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ DOI: doi:10.1038/s41421-023-00564-w Pubmed: 37391393 ]
- Scfv16 nanobody (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Neurokinin b bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Neurokinin-b (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq (g324) (41 kDa, Protein from Homo sapiens)
- Neuromedin-k receptor (nk3r-pfastbac1) (158 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
Human GPR34 -Gi complex bound to M1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8xbh
Q-score: 0.473
Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O
Nat Commun (2024) 15 pp. 902-902 [ DOI: doi:10.1038/s41467-024-45046-z Pubmed: 38326347 ]
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
- (2~{s})-2-azanyl-3-[[(2~{r})-1-ethoxy-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]propan-2-yl]oxy-oxidanyl-phosphoryl]oxy-propanoic acid (617 Da, Ligand)
- Probable g-protein coupled receptor 34 (Complex from Homo sapiens)
- Human gpr34-gi complex bound to m1 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Rattus norvegicus)
- Probable g-protein coupled receptor 34 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8feg
Q-score: 0.471
Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav KB, Olive-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW
Nat Commun (2023) 14 pp. 8064- [ DOI: doi:10.1016/0006-2952(73)90196-2 Pubmed: 38052802 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Ace-tyr-ala-dty-thr-thr-cys-thr-dpn-xt9 (1 kDa, Protein from synthetic construct)
- Water (18 Da, Ligand)
- Kappa-type opioid receptor (34 kDa, Protein from Homo sapiens)
- Kappa opioid receptor in complex with gi1 heterotrimer and a peptide ligand (Complex from Homo sapiens)
Fenoldopam-bound hTAAR1-Gs protein complex
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jlq
Q-score: 0.426
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mgs (43 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- T1am-bound htaar1 (Complex from Homo sapiens)
Cryo-EM structure of CMKLR1 signaling complex
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8sg1
Q-score: 0.546
Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C
PLoS Biol (2023) 21 pp. e3002188-e3002188 [ DOI: doi:10.1371/journal.pbio.3002188 Pubmed: 38055679 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (36 kDa, Protein from Homo sapiens)
- Chemerin 9 (1 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Chemerin-like receptor 1 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin9-cmklr1-gi complex (Complex from Spodoptera frugiperda)
Structure of EP54-C3aR-Go complex
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8i95
Q-score: 0.561
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Structure of ep54-c3ar-go complex (Complex)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Ep54 ligand (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the apo-GPR132-Gi
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8hqe
Q-score: 0.549
Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X
Nat Metab (2023) 5 pp. 1726-1746 [ Pubmed: 37770763 DOI: doi:10.1038/s42255-023-00899-4 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,probable g-protein coupled receptor 132 (57 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo-gpr132-gi (160 MDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)