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Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ts0
Q-score: 0.494
Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE
Nat Commun (2022) 13 pp. 6670-6670 [ DOI: doi:10.1038/s41467-022-33851-3 Pubmed: 36335102 ]
- Urocortin (4 kDa, Protein from Homo sapiens)
- Dominant negative go alpha subunit (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Corticotropin releasing factor receptor 2 (crf2r) bound to urocortin 1 (ucn1) and coupled with g11 proteins (Complex from Homo sapiens)
- G protein gamma subunit (7 kDa, Protein from Rattus norvegicus)
- Corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,corticotropin-releasing factor receptor 2,human corticotropin releasing factor receptor 2 (63 kDa, Protein from Homo sapiens)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
Serotonin 1D (5-HT1D) receptor-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7e32
Q-score: 0.495
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE
Nature (2021) 592 pp. 469-473 [ Pubmed: 33762731 DOI: doi:10.1038/s41586-021-03376-8 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Serotonin 1d (5-ht1d) receptor-gi protein complex (Complex)
- Receptor-gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1d (57 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
Serotonin 1E (5-HT1E) receptor-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7e33
Q-score: 0.48
Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE
Nature (2021) 592 pp. 469-473 [ Pubmed: 33762731 DOI: doi:10.1038/s41586-021-03376-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Receptor-gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- 3-(1-methylpiperidin-4-yl)-1h-indol-5-ol (230 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Serotonin 1e (5-ht1e) receptor-gi protein complex (Complex)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1e (57 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
Dopamine Receptor D3R-Gi-PD128907 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7cmv
Q-score: 0.543
Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE
Mol Cell (2021) 81 pp. 1147- [ Pubmed: 33548201 DOI: doi:10.1016/j.molcel.2021.01.003 ]
- Soluble cytochrome b562,d(3) dopamine receptor (60 kDa, Protein from Homo sapiens)
- Dopamine receptor d3r-gi-pd128907 complex (Complex)
- (4ar,10br)-4-propyl-3,4a,5,10b-tetrahydro-2h-chromeno[4,3-b][1,4]oxazin-9-ol (249 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Chimera protein of soluble cytochrome b562 and d(3) dopamine receptor (Complex from Escherichia coli)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
Cryo-EM structure of SKF-83959-bound dopamine receptor 1 in complex with Gs protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7jvp
Q-score: 0.485
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- (1r)-6-chloro-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (317 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Skf-81297-bound dopamine receptor 1 in complex with gi protein (Complex from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (14 kDa, Protein from synthetic construct)
Cryo-EM structure of Bromocriptine-bound dopamine receptor 2 in complex with Gi protein
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7jvr
Q-score: 0.407
Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE
Cell (2021) 184 pp. 931-942.e18 [ DOI: doi:10.1016/j.cell.2021.01.027 Pubmed: 33571431 ]
- Bromocriptin-bound dopamine receptor 2 in complex with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,d(2) dopamine receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
- Bromoergocryptine (654 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6pb1
Q-score: 0.47
Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE
Mol Cell (2020) 77 pp. 669- [ Pubmed: 32004470 DOI: doi:10.1016/j.molcel.2020.01.013 ]
- Urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Urocortin (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Corticotropin-releasing factor receptor 2 (45 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from synthetic construct)