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Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8gg0
Q-score: 0.58
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) [ DOI: doi:10.1038/s41586-024-07153-1 Pubmed: 38480881 ]
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer with gtp (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7ul2
Q-score: 0.645
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ Pubmed: 36396979 DOI: doi:10.1038/s41594-022-00859-8 ]
- 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid (587 Da, Ligand)
- Neurotensin receptor 1 (47 kDa, Protein from Homo sapiens)
- Complex of ntsr1 and nb6 (Complex from Homo sapiens)
- Nb6 (Complex from Lama glama)
- Sodium ion (22 Da, Ligand)
- Nanobody 6 (14 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Ntsr1 (Complex from Homo sapiens)
CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ul4
Q-score: 0.563
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ Pubmed: 36396979 DOI: doi:10.1038/s41594-022-00859-8 ]
- Megabody 6 (55 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (47 kDa, Protein from Mus musculus)
- N-[(2s)-2-{[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine (424 Da, Ligand)
- Mb6 (Complex from Lama glama)
- Water (18 Da, Ligand)
- Complex of mor and nb6 (Complex from Mus musculus)
- Mor (Complex from Mus musculus)
LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7sf7
Q-score: 0.479
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ DOI: doi:10.1038/s41586-022-04575-7 Pubmed: 35418682 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Isoform 1 of adhesion g protein-coupled receptor l3 (34 kDa, Protein from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Latrophilin 3 (adgrl3) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7sf8
Q-score: 0.544
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ DOI: doi:10.1038/s41586-022-04575-7 Pubmed: 35418682 ]
- Isoform 2 of adhesion g-protein coupled receptor g1 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)