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Cryo-EM structure of the METH-TAAR1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w87
Q-score: 0.567
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ DOI: doi:10.1038/s41586-023-06775-1 Pubmed: 37935377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- (2s)-n-methyl-1-phenylpropan-2-amine (149 Da, Ligand)
- Cryo-em structure of the meth-taar1 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w88
Q-score: 0.59
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ DOI: doi:10.1038/s41586-023-06775-1 Pubmed: 37935377 ]
- Sep363856-bound taar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of the RO5256390-TAAR1 complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w8a
Q-score: 0.551
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F
Nature (2023) 624 pp. 663-671 [ DOI: doi:10.1038/s41586-023-06775-1 Pubmed: 37935377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the ro5256390-taar1 complex (Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- (4s)-4-[(2s)-2-phenylbutyl]-1,3-oxazolidin-2-imine (218 Da, Ligand)
- Water (18 Da, Ligand)
- Trace amine-associated receptor 1 (39 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Palmitic acid (256 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 7xy6
Q-score: 0.468
Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G
Sci Adv (2022) 8 pp. eadd3709-eadd3709 [ DOI: doi:10.1126/sciadv.add3709 Pubmed: 36563137 ]
- Soluble cytochrome b562,adenosine receptor a2b,lgbit (Complex from Oplophorus gracilirostris)
- Soluble cytochrome b562,adenosine receptor a2b,lgbit (69 kDa, Protein from Oplophorus gracilirostris)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide (379 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adenosine receptor bound to an agonist in complex with g protein obtained by cryo-em (Complex from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ DOI: doi:10.1038/s41467-022-34696-6 Pubmed: 36396650 ]
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ DOI: doi:10.1038/s41467-022-34696-6 Pubmed: 36396650 ]
- Gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
PZM21-bound mu-opioid receptor-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8efo
Q-score: 0.472
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- N-[(2s)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-n'-[(2s)-1-(thiophen-3-yl)propan-2-yl]urea (361 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8dcr
Q-score: 0.593
Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 4095-4095 [ Pubmed: 35835792 DOI: doi:10.1038/s41467-022-31823-1 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Dobutamine (301 Da, Ligand)
- Endolysin,endolysin,beta-1 adrenergic receptor chimera (57 kDa, Protein from Meleagris gallopavo)
- Dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric gs-protein (Complex from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8dcs
Q-score: 0.645
Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY
Nat Commun (2022) 13 pp. 4095-4095 [ Pubmed: 35835792 DOI: doi:10.1038/s41467-022-31823-1 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- 4-{[(2s)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3h-indole-2-carbonitrile (287 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Bos taurus)
- Endolysin,endolysin,beta-1 adrenergic receptor chimera (57 kDa, Protein from Meleagris gallopavo)
- Cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric gs-protein (Complex from Meleagris gallopavo)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)